http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mitogenic Signal Transduction by Integrin- and Growth Factor Receptor-mediated Pathways
Rudy Juliano,이정원 한국분자세포생물학회 2004 Molecules and cells Vol.17 No.2
Engagement of cells with the extracellular matrix (ECM) proteins is crucial for various biological proc-esses, including cell adhesion, spreading, proliferation, differentiation, migration, apoptosis, and gene induc-tion, contributing to maintenance of tissue integrity, embryogenesis, wound healing, and the metastasis of tumor cells (Hynes, 2002b; Juliano, 2002). The en-gagement involves cell adhesion mediated by integrins, a large family of cell adhesion receptors that are transmembrane glycoproteins which bind to ECM or to counter-receptors on neighbor cells. In this review, the molecular basis of signaling mediated by integrins and their collaboration with growth factor receptors will be discussed, based on recent observations. Although other cell adhesion receptors including cadherins, se-lectins, syndecans, and the immunoglobulin superfamily of cell adhesion molecules (IgCAMs) can play important roles or be involved in these processes, we suggest read-ers refer to recent outstanding reviews on them (Barclay, 2003; Brummendorf and Lemmon 2001; Panicker et al. 2003).