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      • KCI등재

        Computer-aided design/computer-aided manufacturing of hydroxyapatite scaffolds for bone reconstruction in jawbone atrophy: a systematic review and case report

        Umberto Garagiola,Roberto Grigolato,Rossano Soldo,Marco Bacchini,Gianluca Bassi,Rachele Roncucci,Sandro De Nardi 대한악안면성형재건외과학회 2015 Maxillofacial Plastic Reconstructive Surgery Vol.37 No.-

        Background: We reviewed the biological and mechanical properties of porous hydroxyapatite (HA) compared toother synthetic materials. Computer-aided design/computer-aided manufacturing (CAD/CAM) was also evaluated toestimate its efficacy with clinical and radiological assessments. Method: A systematic search of the electronic literature database of the National Library of Medicine (PubMed-MEDLINE) was performed for articles published in English between January 1985 and September 2013. The inclusioncriteria were (1) histological evaluation of the biocompatibility and osteoconductivity of porous HA in vivo and in vitro,(2) evaluation of the mechanical properties of HA in relation to its porosity, (3) comparison of the biological andmechanical properties between several biomaterials, and (4) clinical and radiological evaluation of the precision ofCAD/CAM techniques. Results: HA had excellent osteoconductivity and biocompatibility in vitro and in vivo compared to other biomaterials. HA grafts are suitable for milling and finishing, depending on the design. In computed tomography, porous HA is amore resorbable and more osteoconductive material than dense HA; however, its strength decreases exponentiallywith an increase in porosity. Conclusions: Mechanical tests showed that HA scaffolds with pore diameters ranging from 400 to 1200 μm hadcompressive moduli and strength within the range of the human craniofacial trabecular bone. In conclusion, usingCAD/CAM techniques for preparing HA scaffolds may increase graft stability and reduce surgical operating time.

      • KCI등재

        Computer-aided design/computer-aided manufacturing of hydroxyapatite scaffolds for bone reconstruction in jawbone atrophy: a systematic review and case report

        Garagiola, Umberto,Grigolato, Roberto,Soldo, Rossano,Bacchini, Marco,Bassi, Gianluca,Roncucci, Rachele,De Nardi, Sandro Korean Association of Maxillofacial Plastic and Re 2016 Maxillofacial Plastic Reconstructive Surgery Vol.38 No.-

        Background: We reviewed the biological and mechanical properties of porous hydroxyapatite (HA) compared to other synthetic materials. Computer-aided design/computer-aided manufacturing (CAD/CAM) was also evaluated to estimate its efficacy with clinical and radiological assessments. Method: A systematic search of the electronic literature database of the National Library of Medicine (PubMed-MEDLINE) was performed for articles published in English between January 1985 and September 2013. The inclusion criteria were (1) histological evaluation of the biocompatibility and osteoconductivity of porous HA in vivo and in vitro, (2) evaluation of the mechanical properties of HA in relation to its porosity, (3) comparison of the biological and mechanical properties between several biomaterials, and (4) clinical and radiological evaluation of the precision of CAD/CAM techniques. Results: HA had excellent osteoconductivity and biocompatibility in vitro and in vivo compared to other biomaterials. HA grafts are suitable for milling and finishing, depending on the design. In computed tomography, porous HA is a more resorbable and more osteoconductive material than dense HA; however, its strength decreases exponentially with an increase in porosity. Conclusions: Mechanical tests showed that HA scaffolds with pore diameters ranging from 400 to $1200{\mu}m$ had compressive moduli and strength within the range of the human craniofacial trabecular bone. In conclusion, using CAD/CAM techniques for preparing HA scaffolds may increase graft stability and reduce surgical operating time.

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