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- 저자 : Robert Y. Peng (검색결과 2 건)
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Li-Yun Lin,Chi-Yun Huang,Kuan-Chou Chen,Robert Y. Peng 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.3
Grapefruit (G) parts contain abundant phenolic acids and fl avonoids (PPNs and FLVs). The wastes created from exocarps,mesocarps (G wastes, GW) and waste blanching water (WBW) lead to a considerable loss of PPNs and FLVs. Here, weassessed Buntan (CB), Buntan Hayata (CBH), and Peiyu (CP) cultivars and observed considerable amounts of PPNs andFLVs. The ethanolic extracts of GW (GWE) and WBW contained gallic acid, protocatechuic acid, chlorogenic acid, caff eicacid, ferulic acid, coumaric acid, naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, and tangeretin (GWC). GWEhas previously been reported to be a relatively active antioxidant, anti-infl ammatory (based on the expression of TNF-αin Raw264.7 cells), antihypertensive, and anti-hyperglycemic compound. The IC 50 values for antihyperglycemic activitywith WBW for α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 ± 0.19 mg/mL) < CBH (41.60 ± 0.16 mg/mL), and those for α-glucosidase were CB (1.80 ± 0.03 mg/mL) < CP (2.97 ± 0.29 mg/mL) < CBH (9.10 ± 0.51 mg/mL). GWC upregulated Glut4 in HepG2 cells, as well as the insulin secretion capability, and intracellular levels in RIN-m5Fcells, and it downregulated DPP4 in HepG2 cells. The IC 50 values for the angiotensin-converting enzyme activity were:CBP (5.10 ± 0.02 mg/mL) < CB (7.24 ± 0.65 mg/mL) < CP (8.60 ± 2.03 mg/mL). Our results indicate that PPNs and FLVspresent in GW are worth reclaiming.
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Chi-Huang Chang,Chung-Yin Chen,Jueen-Ya Chiou,Robert Y. Peng,Chiung-Huei Peng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Astaxanthine (ASTx) is a novel carotenoid nutraceutical occurring in many crustaceans and red yeasts. It has potent antioxidant, photoprotective, hepatodetoxicant, and anti-inflammatory activities. Documented effect of ASTx on treatment of neurodegenerative disease is still lacking. We used the β-amyloid peptide (Aβ) 25–35-treated PC12 model to investigate the neuron-protective effect of ASTx. The parameters examined included cell viability, caspase activation, and various apoptotic biomarkers that play their critical roles in the transduction pathways independently or synergistically. Results indicated that Aβ25–35 at 30μM suppressed cell viability by 55%, whereas ASTx was totally nontoxic below a dose of 5.00μM. ASTx at 0.1μM protected PC12 cells from damaging effects of Aβ25–35 in several ways: (1) by securing the cell viability; (2) by partially down-regulating the activation of caspase 3; (3) by inhibiting the expression of Bax; (4) by completely eliminating the elevation of interleukin-1β and tumor necrosis factor-α; (5) by inhibiting the nuclear translocation of nuclear factor κB; (6) by completely suppressing the phosphorylation of p38 mitogen-activated protein kinase; (7) by completely abolishing the calcium ion influx to effectively maintain calcium homeostasis; and (8) by suppressing the majority (about 75%) of reactive oxygen species production. Conclusively, ASTx may have merit to be used as a very potential neuron protectant and an anti–early-stage Alzheimer's disease adjuvant therapy.
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