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- 저자 : Reddy Vijaya (검색결과 23 건)
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Vijaya Madhuri Devraj,Satish Kumar Vemuri,Rajkiran Reddy Banala,Shravan Kumar Gunda,Gurava Reddy AV,Subbaiah GPV 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.6
Study Design: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). Purpose: To evaluate the efficacy of natural flavonoids as therapeutic drugs against anti-inflammatory processes in the nucleus pulposus (NP) cells using in-vitro and in-silico methods. Overview of Literature: Intervertebral disc (IVD) disease is a common cause of low back pain. Chronic inflammation and degeneration play a significant role in its etiopathology. Thus, a better understanding of anti-inflammatory agents and their role in IVD degeneration and pro-inflammatory cytokines expression is necessary for pain management and regeneration in IVD. Methods: We performed primary cell culture of NP cells; immunocytochemistry; gene expression studies of cytokines, metalloproteases, extracellular proteins, and apoptotic markers using quantitative polymerase chain reaction and reverse transcription-polymerase chain reaction (RT-PCR); cytotoxicity assay (MTT); and molecular docking studies using AutoDock 4.2 software (Molecular Graphics Laboratory, La Jolla, CA, USA) to confirm the binding mode of proteins and synthesized complexes. We calculated the mean±standard deviation values and performed analysis of variance and t -test using SPSS ver. 17.0 (SPSS Inc., Chicago, IL, USA). Results: Molecular docking showed that both Nar and NG bind to the selected genes of interest. Semi-quantitative RT-PCR analysis reveals differential gene expression of collagen (COL)9A1, COL9A2, COL9A3, COL11A2, COMT (catechol-O-methyltransferase), and THBS2 (thrombospondin 2); up regulation of ACAN (aggrecan), COL1A1, COL11A1, interleukin (IL)6, IL10, IL18R1, IL18RAP, metalloprotease (MMP)2, MMP3, MMP9, ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), IGF1R (insulin-like growth factor type 1 receptor), SPARC (secreted protein acidic and cysteine rich), PARK2 (parkin), VDR (vitamin D receptor), and BCL2 (B-cell lymphoma 2); down regulation of IL1A, CASP3 (caspase 3), and nine genes with predetermined concentrations of Nar and NG. Conclusions: The present study evaluated the anti-inflammatory and regenerative efficiencies of Nar and NG in degenerated human NP cells. Altered gene expressions of cytokines, metalloproteases, extracellular proteins, apoptotic genes were dose responsive. The molecular docking (in silico ) studies showed effective binding of these native ligands (Nar and NG) with genes identified as potent inhibitors of inflammation. Thus, these natural flavonoids could serve as anti-inflammatory agents in the treatment of low back pain and sciatica.
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Reddy, Vijaya Ramakrishna,Annamalai, Thangavelu,Narayanan, Vivek,Ramanathan, Arvind Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Background: Epigenetic silencing of tumor suppressor genes due to promoter hypermethylation is one of the frequent mechanisms observed in cancers. Hypermethylation of several tumor suppressor genes involved in cell cycle regulation has been reported in many types of tumors including oral squamous cell carcinomas. LATS1 (Large Tumor Suppressor, isoform 1) is a novel tumor suppressor gene that regulates cell cycle progression by forming complexes with the cyclin dependent kinase, CDK1. Promoter hypermethylation of the LATS1 gene has been observed in several carcinomas and also has been linked with prognosis. However, the methylation status of LATS1 in oral squamous cell carcinomas is not known. As oral cancer is one of the most prevalent forms of cancer in India, the present study was designed to investigate the methylation status of LATS1 promoter and associate it with histopathological findings in order to determine any associations of the genetic status with stage of differentiation. Materials and Methods: Tumor chromosomal DNA isolated from biopsy tissues of thirteen oral squamous cell carcinoma biopsy tissues were subjected to digestion with methylation sensitive HpaII enzyme followed by amplification with primers flanking CCGG motifs in promoter region of LATS1 gene. The PCR amplicons were subsequently subjected to agarose gel electrophoresis along with undigested amplification control. Results: HpaII enzyme based methylation sensitive PCR identified LATS1 promoter hypermethylation in seven out of thirteen oral squamous cell carcinoma samples. Conclusions: The identification of LATS1 promoter hypermethylation in seven oral squamous cell carcinoma samples (54%), which included one sample with epithelial dysplasia, two early invasive and one moderately differentiated lesions indicates that the hypermethylation of this gene may be one of the early event during carcinogenesis. To the best of our knowledge, this is the first study to have explored and identified positive association between LATS1 promoter hypermethylation with histopathological features in oral squamous cell carcinomas.
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Reddy, Saripally Sudhaker,Sree, Vijaya Gopalan,Park, Ho-Yeol,Maheshwaran, Athithan,Song, Myungkwan,Jin, Sung-Ho Elsevier 2017 Dyes and pigments Vol.145 No.-
<P><B>Abstract</B></P> <P>A rational design strategy is proposed for synthesis of a new deep-blue emitter/dopant (denoted as TPA-3FA) based on triphenylamine (TPA) as the core with the addition of diethylfluorene/acridine analogues to frame a star-shaped material for solution processable high performance OLEDs. The photophysical, thermal, electrochemical, electronic, and hole transporting properties of TPA-3FA are examined. Most importantly, this rational design strategy of introducing diethylfluorene between TPA and acridine imparts high rigidity and non-planarity, which in turn completely suppress intermolecular interactions, and thus yields a strong narrow deep-blue fluorescence with a high quantum yield. Moreover, a solution processed non-doped device with TPA-3FA as an emitter exhibits excellent device performance with a maximum external quantum efficiency (EQE) of 4.43%, CIE (<I>x</I>,<I>y</I>) coordinates of (0.153, 0.045) and good device stability. The device performance was significantly improved with an EQE of 6.11% and CIE (<I>x</I>,<I>y</I>) coordinates of (0.156, 0.049) after doping into a host. The same device when processed in a halogen-free solvent exhibited an impressive EL performance (EQE: 5.72%; CIE (0.157, 0.046)).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Rationally designed and synthesized an efficient deep-blue fluorescent emitter for solution processed OLEDs. </LI> <LI> A nondoped device exhibits an excellent device performance with an EQE of 4.43% and CIE (<I>x</I>,<I>y</I>) value of (0.153,0.045). </LI> <LI> Doped device performance is dramatically improved EQE of 6.11%; CIE (<I>x</I>,<I>y</I>):(0.156, 0.049). </LI> <LI> In a halogen-free solvent-processed device is also showed EQE of over 5.7% with a small CIE <I>y</I> value. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Reddy, Rangareddygari Manohar,Suryanarayana, Nagabathula,Ojha, Nand Gopal,Hansda, Ganga,Rai, Suresh,Prakash, Nanjappa Basappa Vijaya Korean Society of Sericultural Science 2009 International Journal of Industrial Entomology Vol.18 No.2
Daba ecorace of Antheraea mylitta Drury (Lepidoptera: Saturniidae), the semi domesticated Indian tropical tasar silkworm being reared outdoor; the egg and silk yields are dependent of genotype environment interaction. The insufficient maintenance and multiplication of its P4 seed stock need a coherent as well as scientific strategy to safeguard breed potential, being commercially applied ecorace. The sort-out lines of P4 stock studied over five generations highlighting on commercial trait up gradation suits for a tropical crop season, revealed enhanced performance. The line with high pupal parents (T2) shown improved fecundity (12.9%) and the line with high shell parents (T3) recorded higher shell weight (40.0%) and silk ratio (24.1%). While, the line of high pupal female and high shell male (T4) reveal enhancement in fecundity (9.0%), egg hatching (14.1%), shell weight (50.0%), silk ratio (35.2%) and absolute silk yield (52.0%) indicating the need and role of varied basic seed stock lines. The approach could improve economically vital egg fecundity and cocoon shell weights besides balancing them in same line for commercial operation. The progressive show of lines (T1 to T4) along successive generations (G1 to G5), in spite of passing through seed crop (Jul-Aug) and commercial crop (Sep-Nov) seasons emphasize their compatibility. The study infers that the strategic plan of combining preferred parental phenotypes, methodical selection for desired commercial trait(s) through generations with best possible genotype environment interaction has enriched P4 stock with elevation in needy trait(s) besides assuring choice of suitable lines for seasons and regions and timely replenishment of basic seed of Daba ecorace.
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Reddy, Rangareddygari Manohar,Suryanarayana, Nagabathula,Sinha, Manoj Kumar,Gahlot, Nand Singh,Hansda, Ganga,Ojha, Nand Gopal,Prakash, Nanjappa Basappa Vijaya Korean Society of Sericultural Science 2009 International Journal of Industrial Entomology Vol.19 No.1
Silk filament progression study applying backcross breeding with recipient parent Jata and donor parent Daba ecoraces of tropical tasar silkworm, Antheraea mylitta Drury conducted during 2006 to 2008, revealed introgression of filament denier (10.2 d) superior to both parents at BC4 level. Also, the silk waste (0.35%) and filament breaks (2.6 nos) were reduced compared to both parents, while the filament length (973 m) and non break filament (296 m) improved over donor and could attain closer to recipient parent. The best performance of Jata $\times$ Daba at F1 level, with highest silk filament length (1646 m) of 12.5 d denier, denotes heterosis impact on silk trait with parental heterogenousity, an advantage to exploit silk filament yield. The progression of quality in terms of finer filament denier, less silk waste and least number of filament breaks over both parents and improvement in filament length and non break filament over donor parent except for a marginal shortage against recipient at BC4 level indicates the prospects of Jata and Daba ecoraces as source of breeding material for qualitative improvement of tasar silk filament. The study suggests that the commercially important finer denier of tasar silk filament can be attained with minor reduction in silk yield of wild Jata ecorace by adopting repeated backcrossing for four generations with semi domesticated Daba ecorace.
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Srinivasa Reddy Ronda,Pavani Lakhsmi Chandrika Parupudi,Sandeep Vemula,Santhosh Tumma,Mahendran Botlagunta,Vijaya Saradhi Settaluri,Smita Lele,Suraj Sharma,Chari Kandala 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.10
This work describes the medium optimization of γ-Linolenic acid (GLA) production by Spirulina platensisusing one-factor and orthogonal array design methods. In the one-factor experiments, NaHCO3 (9 mg L−1), NaNO3(13.5 mg L−1) and MgSO4·7H2O (11.85 mg L−1) proved to be the best components for GLA production. The optimalpH for GLA production by the alga was 9.2. Based on the delta values, NaHCO3 showed the greatest effect on the GLAproduction of the various factors tested, followed in decreasing order by MgSO4·7H2O, NaNO3 and K2SO4. The max-imum GLA yield obtained was 19.2 mgL−1in the presence of optimum concentrations of NaHCO3 (20 g L−1), NaNO3(3 g L−1), MgSO4·7H2O (0.5 g L−1) and K2SO4 (1.5 g L−1). Because of the slow growth rate of the algae, the practiceof robust orthogonal array methods during the optimization of medium components can result in the production of anoptimal biomass and a higher GLA yield for nutraceutical applications.
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Hansda, G.,Reddy, R. Manohar,Sinha, M. K.,Ojha, N. G.,Prakash, N. B. Vijaya Korean Society of Sericultural Science 2008 International Journal of Industrial Entomology Vol.17 No.2
Indian tropical tasar silkworm, Antheraea mylitta D is reported to have forty four ecoraces by way of their adoption to different topographical and vegetational conditions. Of late, another ecorace 'JATA' - univoltine under in-situ condition has been explored which is localized in Thakurmunda area of the foot hills of Simlipal biosphere (Mayurbhanj district) of Orissa, India. The ecorace 'Jata' exhibits superior economic characters over widely commercialized ecoraces of Daba and Sukinda. The cocoon production of localized 'Jata' ecorace is depleting day by day in in-situ condition. In the present study, efforts were made to stabilize the ecorace 'Jata' under ex-situ condition at Ranchi (Jharkhand), where the 'Jata' ecorace silkworms were reared on Terminalia tomentosa for four successive generations during 2006 and 2007 and the cocoons were preserved in grainage house under prevailing climatic conditions. The results indicated change in voltinism behaviour of the 'Jata' ecorace from univoltine to bivoltine. The rearing performance and grainage efficiencies indicate the tendency of 'Jata' ecorace towards acclimatization and stabilization under Ranchi climatic conditions. The 'Jata' ecorace manifests the prospects for acclimatization, stabilization and commercial exploitation.
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Rangareddygari Manohar Reddy,Nagabathula Suryanarayana,Manoj Kumar Sinha,Nand Singh Gahlot,Ganga Hansda,Nand Gopal Ojha,Nanjappa Basappa Vijaya Prakash 한국잠사학회 2009 International Journal of Industrial Entomology Vol.19 No.1
Silk filament progression study applying backcross breeding with recipient parent Jata and donor parent Daba ecoraces of tropical tasar silkworm, Antheraea mylitta Drury conducted during 2006 to 2008, revealed introgression of filament denier (10.2 d) superior to both parents at BC4 level. Also, the silk waste (0.35%) and filament breaks (2.6 nos) were reduced compared to both parents, while the filament length (973 m) and non break filament (296 m) improved over donor and could attain closer to recipient parent. The best performance of Jata x Daba at F1 level, with highest silk filament length (1646 m) of 12.5 d denier, denotes heterosis impact on silk trait with parental heterogenousity, an advantage to exploit silk filament yield. The progression of quality in terms of finer filament denier, less silk waste and least number of filament breaks over both parents and improvement in filament length and non break filament over donor parent except for a marginal shortage against recipient at BC4 level indicates the prospects of Jata and Daba ecoraces as source of breeding material for qualitative improvement of tasar silk filament. The study suggests that the commercially important finer denier of tasar silk filament can be attained with minor reduction in silk yield of wild Jata ecorace by adopting repeated backcrossing for four generations with semi domesticated Daba ecorace.
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Rangareddygari Manohar Reddy,Nagabathula Suryanarayana,Nand Gopal Ojha,Ganga Hansda,Suresh Rai,Nanjappa Basappa Vijaya Prakash 한국잠사학회 2009 International Journal of Industrial Entomology Vol.18 No.2
Daba ecorace of Antheraea mylitta Drury (Lepidoptera: Saturniidae), the semi domesticated Indian tropical tasar silkworm being reared outdoor; the egg and silk yields are dependent of genotype environment interaction. The insufficient maintenance and multiplication of its P4 seed stock need a coherent as well as scientific strategy to safeguard breed potential, being commercially applied ecorace. The sort-out lines of P4 stock studied over five generations highlighting on commercial trait up gradation suits for a tropical crop season, revealed enhanced performance. The line with high pupal parents (T2) shown improved fecundity (12.9%) and the line with high shell parents (T3) recorded higher shell weight (40.0%) and silk ratio (24.1%). While, the line of high pupal female and high shell male (T4) reveal enhancement in fecundity (9.0%), egg hatching (14.1%), shell weight (50.0%), silk ratio (35.2%) and absolute silk yield (52.0%) indicating the need and role of varied basic seed stock lines. The approach could improve economically vital egg fecundity and cocoon shell weights besides balancing them in same line for commercial operation. The progressive show of lines (T1 to T4) along successive generations (G1 to G5), in spite of passing through seed crop (Jul-Aug) and commercial crop (Sep-Nov) seasons emphasize their compatibility. The study infers that the strategic plan of combining preferred parental phenotypes, methodical selection for desired commercial trait(s) through generations with best possible genotype environment interaction has enriched P4 stock with elevation in needy trait(s) besides assuring choice of suitable lines for seasons and regions and timely replenishment of basic seed of Daba ecorace.
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