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RISS 인기검색어
- 검색키워드
- 저자 : Raja Majumder (검색결과 3 건)
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Raja Majumder,Lopamudra Adhikari,Chowdhury Mobaswar Hossain,Moonmun Dhara,Jinamitra Sahu 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Olax psittacorum (Lam.) Vahl. has versatile ethnopharmacological healing property in addition with incomplete research are adequate pieces of information to support the choice of the plant to build up proper data in acute and sub-chronic toxicological, cytotoxicity with ex vivo and in vivo antioxidant profile as well as qualitative analytical illustration through GC–MS of the selected extracts obtained from different parts of the plant. We have extracted leaf methanolic extract (LME), stem methanolic extract (SME), stem aqueous extract (SAE) and fruits aqueous extract (FrAE) for the above mentioned respective studies. OECD guideline 420 and 407, brine shrimp lethality (BSLA), lipid peroxidation, catalase assay was conducted to gather information on toxicity, cytotoxicity, and antioxidant properties respectively. BSLA study indicates that LME may be a good choice to develop as an anticancer drug for future perspective ( LC50 = 41.88 μg/ml). Both LME and SME have been selected for ex vivo and in vivo antioxidant analysis on the basis of their low toxicity and GCMS analysis. Moreover, in vivo lipidperoxidation as well as catalase assay both having significant difference (P < 0.05) between the groups except LME 200 and positive control (P = 0.084) as well as LME 200 and SME 100 (P = 0.054) respectively. This study justifies that high dose exposure of FrAE, SAE, and SME could be so toxic due to changes in biochemical parameters and in comparison, LME is safer according to the significant (P < 0.05) outcome statistically. LME and SME are safe to consume at a dose of ≤ 200 mg/kg/bw as herbal supplements with antioxidant property.
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Olax psittacorum (Lam.) Vahl. (Olacaceae): current status and future prospects as an herbal plant
Majumder Raja,Adhikari Lopamudra,Dhara Moonmun 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2
Olax psittacorum (Lam.) Vahl. traditionally used by the tribal community of ‘INDIA’ to heal conditions such as pain, psoriasis, mouth-ulcer, anemia, constipation as well as diabetes. Documented scientific shreds of evidence like antipyretic, anti-inflammatory, antimicrobial, anti-viral, anti-cancer, toxicity profile improved its medicinal value. Chromatographic evaluation (GC–MS) proven near about presence of 25 compounds. Among them, hexadecanoic methyl ester, β-sitosterol, phytol, methyl salicylate, 13-docosenamide, and oleanolic acid are significant and contribute to its successful medicinal properties. The toxicity study also revealed the safety of the consumption of the leaf part. Still, consecutive gaps need to be exploring to gather evidence of its contribution to curing different ailments, especially upon the ulcer, anemia, and identification of the presence of lead compounds as an upcoming future research proposal. The ‘Internet Scholar’, ‘Study Guide’, ‘PubMed’, ‘ScienceDirect’, ‘Scopus’, and ‘Sodhganga’ web site have been accessed to gather information about detailed scientific research as well as traditional information from authenticated sources that have been published in the English language. The various folklore claimed medicinal properties like anti-ulcer, aphthous ulcer, analgesic, anti-diabetic, anti-anemic, etc. yet to be justified scientifically with lead compounds that can support the rationality being used as folklore. This plant could be a good choice to explore its importance within the pharmacognostic field of drug development and might be a better source of herbal derived lead compounds which can help to heal ulcer or anemia that can effectively make a credible addition to treatment among the civilization as a natural source of therapeutic compounds.
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Anukul Ch Mandal,Poly Patra,Raja Majumder,Debashish Kumar Ghosh,Gouri Sankar Bhunia 대한공간정보학회 2018 Spatial Information Research Vol.26 No.1
Discernibility of Bhagirathi river course change detection was prepared via Remote Sensing and GIS in Murshidabad district among 41 years of period (1977–2017). Landsat MSS, TM, ETM?, TM, OLI sensor data from 1977, 1990, 2000, 2010 and 2017 respectively were considered to demarcate the chronological changes of the river course. Normalized Difference Water Index was used to extract the surface water bodies. Seventy-seven cross sections have been drawn to delimit the river course shifting pattern. The results shows that he Bhagirathi river course has been shifting towards south and west direction in different places, particularly in the lower and middle courses of the river. The adjacent riverine region has remained undeveloped due to infrastructure damaged by flood, changing course. Therefore, present study may be helpful for the overall management and planning for future prevention of flood, changing course, loss of properties.
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