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½ ⅓ ⅔ ¼ ¾ ⅛ ⅜ ⅝ ⅞ ¹ ² ³ ⁴ ⁿ ₁ ₂ ₃ ₄
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        Toxicological evaluation, brine shrimp lethality assay, in vivo and ex vivo antioxidant assessment followed by GC–MS study of the extracts obtained from Olax psittacorum (Lam.) Vahl

        Raja Majumder,Lopamudra Adhikari,Chowdhury Mobaswar Hossain,Moonmun Dhara,Jinamitra Sahu 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3

        Olax psittacorum (Lam.) Vahl. has versatile ethnopharmacological healing property in addition with incomplete research are adequate pieces of information to support the choice of the plant to build up proper data in acute and sub-chronic toxicological, cytotoxicity with ex vivo and in vivo antioxidant profile as well as qualitative analytical illustration through GC–MS of the selected extracts obtained from different parts of the plant. We have extracted leaf methanolic extract (LME), stem methanolic extract (SME), stem aqueous extract (SAE) and fruits aqueous extract (FrAE) for the above mentioned respective studies. OECD guideline 420 and 407, brine shrimp lethality (BSLA), lipid peroxidation, catalase assay was conducted to gather information on toxicity, cytotoxicity, and antioxidant properties respectively. BSLA study indicates that LME may be a good choice to develop as an anticancer drug for future perspective ( LC50 = 41.88 μg/ml). Both LME and SME have been selected for ex vivo and in vivo antioxidant analysis on the basis of their low toxicity and GCMS analysis. Moreover, in vivo lipidperoxidation as well as catalase assay both having significant difference (P < 0.05) between the groups except LME 200 and positive control (P = 0.084) as well as LME 200 and SME 100 (P = 0.054) respectively. This study justifies that high dose exposure of FrAE, SAE, and SME could be so toxic due to changes in biochemical parameters and in comparison, LME is safer according to the significant (P < 0.05) outcome statistically. LME and SME are safe to consume at a dose of ≤ 200 mg/kg/bw as herbal supplements with antioxidant property.

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        Olax psittacorum (Lam.) Vahl. (Olacaceae): current status and future prospects as an herbal plant

        Majumder Raja,Adhikari Lopamudra,Dhara Moonmun 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.2

        Olax psittacorum (Lam.) Vahl. traditionally used by the tribal community of ‘INDIA’ to heal conditions such as pain, psoriasis, mouth-ulcer, anemia, constipation as well as diabetes. Documented scientific shreds of evidence like antipyretic, anti-inflammatory, antimicrobial, anti-viral, anti-cancer, toxicity profile improved its medicinal value. Chromatographic evaluation (GC–MS) proven near about presence of 25 compounds. Among them, hexadecanoic methyl ester, β-sitosterol, phytol, methyl salicylate, 13-docosenamide, and oleanolic acid are significant and contribute to its successful medicinal properties. The toxicity study also revealed the safety of the consumption of the leaf part. Still, consecutive gaps need to be exploring to gather evidence of its contribution to curing different ailments, especially upon the ulcer, anemia, and identification of the presence of lead compounds as an upcoming future research proposal. The ‘Internet Scholar’, ‘Study Guide’, ‘PubMed’, ‘ScienceDirect’, ‘Scopus’, and ‘Sodhganga’ web site have been accessed to gather information about detailed scientific research as well as traditional information from authenticated sources that have been published in the English language. The various folklore claimed medicinal properties like anti-ulcer, aphthous ulcer, analgesic, anti-diabetic, anti-anemic, etc. yet to be justified scientifically with lead compounds that can support the rationality being used as folklore. This plant could be a good choice to explore its importance within the pharmacognostic field of drug development and might be a better source of herbal derived lead compounds which can help to heal ulcer or anemia that can effectively make a credible addition to treatment among the civilization as a natural source of therapeutic compounds.

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