http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Adaptive Importance Sampling Method with Response Surface Technique
Ra Kyeong-Woong,Kim Sang-Hyo,Lee Sang-Ho 한국전산구조공학회 1998 한국전산구조공학회논문집 Vol.11 No.4
풍요표본추출기 법증에 서도 층화표본추출법플 이용한 적웅척 증요표본추출기법이 일반적 으로 가장 합리적인 것 으 로 알려져 있다. 그러나 확릅장 유한요소모형분제와 갇이 기본 확률변수의 규모 가 큰 경우에 는 층화표본추출법에 서 요구되는 기본적인 표본점의 규 모가 급즙하여 효플성이 떨어지게 된다. 본 연구에서는 이러한 한계성 윤 극복하 기 위하여 충화표본추출에서 7] 본확-플변수룹 사용하는 대신에 기본확률변 수뜰의 함수이며 새로운 확률변수인 응답 값흙 이용하는 방법 음 개발하였다 여기에서 웅답값은 일반적인 함수형태로 표시퍼지 않으며. 한 번의 응답계 산에 많은 계산량이 소요되므로 이러한 운제점윤 해결하기 워하여 응답변식 윤 이용한 층화표본추출볍 윤 개발하였다‘ 개 발된 기법에서는 기본확률 변수의 모의발생균묘는 기존의 기본확률변수를 이용한 층화표본추출법에서 보다 증가하 지만 매우 많은 계산량찰 요구하는 실제 응답해석규모는 웅답연삭윤 이용함으로써 획기적으로 감소되었다. 확히 본 기법은 기 본확륨변 수의 규모가 크고 대상한계상태의 파괴 확블이 낮응-수룩 기존의 방법과 비교해 효율성이 증대되 는 것으르 분석되었다, In this study the adaptive importance sampling method has been developed with the stratified sampling technique in terms of the structural response instead of basic multi -dimensional random variables. To reduce the large amout of computational time required in stratified sampling with multi-variate problems such as random field finite element models. the response surface method is utilized. By considering the structural response as only one random variable rather than considering all t.he basic random variables‘ the simulation number of t.he original structural analysis is significantly redllced compared with those reqllired in the traditional techniques. The developed method has been found to provide the appropriate information more efficiently when the limit state involves a large number of basic random variables and the exceeding probability is small
Kyeong, Kyu-Sang,Hong, Seung Hwa,Kim, Young Chul,Choi, Woong,Myung, Sun Chul,Lee, Moo Yeol,You, Ra Young,Kim, Chan Hyung,Kwon, So Yeon,Suzuki, Hikaru,Park, Yeon Jin,Jeong, Eun-Hwan,Kim, Hak Soon,Kim, The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.5
Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing $K^+$ channels (TASK-2) might be one of the candidates for the regulation of uterine circular smooth muscles in mice. In this study, we tried to show the mechanisms of relaxation via TASK-2 channels in marine myometrium. Isometric contraction measurements and patch clamp technique were used to verify TASK conductance in murine myometrium. Western blot and immunehistochemical study under confocal microscopy were used to investigate molecular identity of TASK channel. In this study, we showed that TEA and 4-AP insensitive non-inactivating outward $K^+$ current (NIOK) may be responsible for the quiescence of murine pregnant longitudinal myometrium. The characteristics of NIOK coincided with two-pore domain acid-sensing $K^+$ channels (TASK-2). NIOK in the presence of $K^+$ channel blockers was inhibited further by TASK inhibitors such as quinidine, bupivacaine, lidocaine, and extracellular acidosis. Furthermore, oxytocin and estrogen inhibited NIOK in pregnant myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed stronger inhibition of NIOK by quinidine and increased immunohistochemical expression of TASK-2. Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in the longitudinal myometrium of mouse. Activation of TASK-2 channels seems to play an essential role for relaxing uterus during pregnancy and it might be one of the alternatives for preventing preterm delivery.
The Role of ATP-Sensitive K+ Channel (KATP channel) in Longitudinal Smooth Muscles of Murine Uterus
( Seung Hwa Hong ),( Kyu Sang Kyeong ),( Yeon Jin Park ),( Iii Woon Ji ),( Eun Hwan Jeong ),( Hak Soon Kim ),( Chan Hyung Kim ),( Woong Choi ),( Wen Xie Xu ),( Ra Young You ),( Sang Jin Lee ),( Young 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-