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- 저자 : Qinyu Li (검색결과 2 건)
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Ming Li,Pengcheng Sun,Kaikai Dong,Ye Xin,Aslee TaiLulu,Qinyu Li,Jing Sun,Min Peng,Ping Shi 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2
Chemerin exhibits an inhibitory eff ect on hepatocellularcarcinoma; however, the underlying mechanismis unclear. Here, low chemerin expression was confi rmedin samples of liver cancer patients and hepatoma cells. Chemerin altered hepatoma cell morphology but had noeff ect on normal hepatocytes. Chemerin inhibited proliferationof several human hepatoma cell lines. Real-time PCRdetection of hepatocellular carcinoma markers showed thatmRNA levels of albumin and A-type gamma-glutamyltransferase increased whereas those of alpha-fetoprotein,alkaline phosphatase, B-type gamma-glutamyl transferase,insulin-like growth factor II, and human telomerase reversetranscriptase decreased in chemerin-treated SMMC7721cells. Western blotting revealed that chemerin up-regulatedalbumin and vimentin expressions, and downregulated alpha-fetoprotein expression. Phosphorylated STAT3 wassignifi cantly up-regulated, whereas phosphorylated ERKand AKT were signifi cantly downregulated by chemerin. Chemerin decreased phosphorylated ERK and AKT expressionand the cell proliferation induced by PI3K activator 740Y-P but could not signifi cantly alter phosphorylated STAT3expression and the cell growth induced by STAT3 inhibitorNSC74859. In conclusion, chemerin reversed the malignantphenotype and induced SMMC7721 cell diff erentiation byinhibiting MAPK/ERK and PI3K/AKT signaling; growthinhibition by chemerin is not directly related to the JAK/STAT signaling pathway. Our study provides novel evidencethat chemerin could be utilized for liver cancer treatment.
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Tang Sida,Huang Xiaohong,Li Qunzhan,Yang Naiqi,Liao Qinyu,Sun Ke 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3
Traction power fl uctuations have economic and environmental eff ects on high-speed railway system (HSRS). The combination of energy storage system (ESS) and HSRS shows a promising potential for utilization of regenerative braking energy and peak shaving and valley fi lling. This paper studies a hybrid energy storage system (HESS) for traction substation (TS) which integrates super-capacitor (SC) and vanadium redox battery (VRB). According to the characteristics of the traction load under actual operating conditions, an energy management strategy with fi xed-period control (FPC) is proposed, which fully leverages the periodicity and regularity of HSRS operation. To achieve the optimal size, economic feasibility is selected as the optimization objective, which is fully assessed in terms of Net Present Value (NPV). The optimization constraints are formulated in which the Discrete Fourier Transform (DFT) is performed for power allocation between SC and VRB. Besides, an improved mutation-based particle swarm optimization (IMBPSO) is proposed to effi ciently solve the optimization and enhance convergence performance. Finally, combined with the measured traction load data, the eff ectiveness of the FPC energy management strategy is verifi ed and the optimal scale of the HESS is provided.
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