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RISS 인기검색어
- 검색키워드
- 저자 : Pramod Bahadur KC (검색결과 3 건)
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Maharjan, Anju,Gautam, Ravi,Jo, JiHun,Acharya, Manju,Lee, DaEun,Pramod, Bahadur KC,Gim, Jin,Sin, Sojung,Kim, Hyocher,Kim, ChangYul,Lee, SooYeon,Lee, SooJin,Heo, Yong,Kim, HyoungAh Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.2
Background: Occupational hazards in crop farms vary diversely based on different field operations as soil management, harvesting processes, pesticide, or fertilizer application. We aimed at evaluating the immunological status of crop farmers, as limited systematic investigations on immune alteration involved with crop farming have been reported yet. Methods: Immunological parameters including plasma immunoglobulin level, major peripheral immune cells distribution, and level of cytokine production from activated T cell were conducted. Nineteen grape orchard, 48 onion open-field, and 21 rose greenhouse farmers were participated. Results: Significantly low proportion of natural killer (NK) cell, a core cell for innate immunity, was revealed in the grape farmers (19.8±3.3%) in comparison to the onion farmers (26.4±3.1%) and the rose farmers (26.9±2.5%), whereas cytotoxic T lymphocyte proportion was lower in the grape and the onion farmers than the rose farmers. The proportion of NKT cell, an immune cell implicated with allergic response, was significantly higher in the grape (2.3±0.3%) and the onion (1.6±0.8%) farmers compared with the rose farmers (1.0±0.4%). A significantly decreased interferon-gamma:interleukin-13 ratio was observed from ex vivo stimulated peripheral blood mononuclear cells of grape farmers compared with the other two groups. The grape farmers revealed the lowest levels of plasma IgG1 and IgG4, and their plasma IgE level was not significantly different from that of the onion or the rose farmers. Conclusion: Our finding suggests the high vulnerability of workplace-mediated allergic immunity in grape orchard farmers followed by open-field onion farmers and then the rose greenhouse farmers.
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Ravi Gautam,DaEun Lee,Anju Maharjan,Manju Acharya,JiHun Jo,HyunJi Park,YuBin Kim,Pramod Bahadur KC,Chang Yul Kim,HyoungAh Kim,JiMin Choi,SooMin Lim,YoungWoo Shin,SuBin Yang,Yong Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Nanoparticles (NPs), fine particles ranging from 1 to 100 nm, are being used extensively in various fields including industry, agriculture, engineering. Nanoparticles also have become the imperative parts of cosmetic and dermal products owing to the higher benefits over their counter bulk particles. Manganese oxide (Mn2O3) and copper oxide (CuO) are used in cosmetics and dermal products owing to their UV protection and antimicrobial properties and also to make products transparent and aesthetically acceptable. Although Mn2O3 and CuO are used in consumer products that get exposed to the skin, their skin sensitization potential has not been well investigated. In this study we employed, Local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method (LLNA: BrdU-FCM) to predict the skin sensitization (SS) potential of nanoparticles. LLNA: BrdU-FCM is a method for screening of SS potential that addressed the activation and proliferation of T-lymphocytes, key event-4 (KE-4), on adverse outcome pathway (AOP) for SS. Mn2O3 (5%, 10%, and 25%), and CuO (5%, 10%, and 25 %) NPs were suspended in dimethyl sulfoxide (DMSO) for experimentation. AOO (acetone: olive oil = 4:1) and α-hexyl cinnamaldehyde were used as negative and positive control respectively. Mn2O3 and CuO NPs were both classified as non-sensitizer with maximum stimulation indices of 1.4 and 0.99 respectively. Although both NPs were classified as non-sensitizer using LLNA: BrdU-FCM, further assays addressing other KEs of AOP for SS could be carried out as confirmation and cautious use of products containing these nanoparticles is recommended as various studies have revealed their toxicity in vitro . This study was supported by the Korea National Research Foundation (grant number: 2020R1I1A3A0403650911) and the Ministry of Environment-Educational training program for the management of information on the hazards and risk of chemical substances.
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Ravi Gautam,Ji Hun Jo,Ha Jung Han,Anju Maharjan,Manju Acharya,Da Eun Lee,Hyun Ji Park,Yu Bin Kim,Ji Sun Lee,Jin Ho Kim,Pramod Bahadur KC,Chang Yul Kim,Yong Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Exposure to metal arsenic (As) has been proposed as a risk factor for autism spectrum disorders (ASDs), which are neurodevelopmental disorders with worldwide increasing in its incidence. In the present study, BTBR T+tf/J (BTBR) mice with ASD-like behavioral characteristics and control highly social FVB mice were orally exposed to 0.1 mM arsenic (III) oxide for 4 wk, and were compared to investigate neuroimmunological or behavioral abnormalities. IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As. Levels of IL-4, IFN-γ, IL-1β, IL-17, and TNF-α in brain tissue were lowered in BTBR-As relative to BTBR-C, but this tendency was not observed with FVB mice. BTBR-As mice demonstrated decrease in relative travel distance and time spent in the center vs. the periphery of open field arena compared to BTBR-C. Sociability evaluation using three-way chamber test did not clearly demonstrate As-mediated alteration in social interaction in BTBR mice. These findings suggest the potential for As-driven predominant T H2-like reactivity profile in the brain microenvironment of BTBR mice and for As-mediated locomotive impairment probably associated with ASD. This study was supported by research grant from Daegu Catholic University in 2019 and the Ministry of Environment-Educational training program for the management of information on the hazards and risk of chemical substances.
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