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오늘 본 자료
Hamidreza Abdolsamadi,Fatemeh Ahmadi-Motamayel,Nasrin Rafieian,Mohammad Taghi Goodarzi,Javad Feradmal,Seyed-Mostafa Hoseyni,Mina Jazayeri,Zahrasadat Taghavi,Poorandokht Davoodi 전남대학교 의과학연구소 2014 전남의대학술지 Vol.50 No.2
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknownetiology. Many studies have implicated the protective role of antioxidants in suchdiseases. The aim of this study was to compare salivary total antioxidant capacity (TACand malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels inpatients with erosive OLP and healthy individuals. Thirty six patients with OLP (14males, 22 females) and 36 control subjects (15 males, 21 females), matched for age andsex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidantvitamin levels were measured in both case and control groups. The salivarylevel of MDA was significantly higher (p<0.001) in patients than in controls. In patientswith OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantlydecreased in patients with OLP (p<0.001). In addition, a positive correlationwas found between the decrease in the salivary amount of vitamin C and that in vitaminE in patients and controls. In addition to the lower salivary levels of antioxidant vitaminsand the lower TAC, the higher level of MDA in patients with OLP suggests thatfree radicals and the resulting oxidative damage may be important in the pathogenesisof OLP lesions.