Prevalence of Oral Mucosal Lesions in Male Smokers and Nonsmokers

Fatemeh Ahmadi-Motamayel,Parisa Falsafi,Zahra Hayati,Farzad Rezaei,Jalal Poorolajal 전남대학교 의과학연구소 2013 전남의대학술지 Vol.49 No.2

Tobacco smoking is one of the most important risk factors for the development of oral mucosal lesions such as leukoplakia and hairy tongue. Controversy exists in the literature,however, about the prevalence of oral lesions in smokers. The aim of this study was to evaluate oral lesions in male smokers compared with nonsmokers in Hamadan. A total of 516 male participants were assessed, 258 of whom were smokers and 258 of whom were healthy nonsmokers. The prevalence of lesions was evaluated by clinical observation and biopsy. We found that the most prevalent lesions among smokers were gingival problems and coated tongue; smokers had significantly more lesions than did nonsmokers. Malignant and premalignant lesions were found in a higher age range. Among all participants in our study, we found a large number of oral mucosal lesions in smokers that had a strong correlation with smoking. Dental services need to implement care and health education for smokers to promote health.

Knowledge of General Dentists and Senior Dental Students in Iran about Prevention of Infective Endocarditis

Fatemeh Ahmadi-Motamayel,Samaneh Vaziri,Ghodratollah Roshanaei 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.1

Infective endocarditis (IE) is an infection of the endothelial surface of the heart and heart valves with serious, even fatal, complications and that often requires long-term and expensive treatment. Dental procedures may lead to IE in high-risk patients. The aim of this study was to evaluate and compare the knowledge of general dentists and dental students concerning the prevention of IE in Hamadan, Iran. In this cross-sectional study, the awareness of general dentists and dentistry students concerning the prevention of IE was evaluated during 2010. A questionnaire was prepared and administered to 58 final-year dental students and 96 general dental practitioners in Hamadan. A total of 154 persons completed the questionnaire. The questionnaire consisted of some demographic questions and questions about awareness of IE in three sections. The gathered data were analyzed by using descriptive statistics, Pearson’s chi-square test, Mann-Whitney test, and independent t-tests. The gathered data showed that dentistry students answered the questions about awareness of the prevention of IE more correctly than did general dentists. The overall knowledge of endocarditis prophylaxis among students and dentists was about 65% and 56%,respectively. The students’ knowledge was better because 94.9% of the students had desired (acceptable) and relatively desired knowledge; this result for dentists, however,was 82.3%. In our study, the overall awareness level of the study population was moderate. Dentist and students believed that patients with prosthetic valves and previous IE were the most common cardiac disease cases that required prophylaxis. The most common prophylactic regimen was in accordance with the guidelines of the American Heart Association and was a single dose of 2 g amoxicillin 1 hour before treatment. The results indicated that gender had no effect on the level of knowledge;however, there was a statistically significant relationship between age and level of knowledge.

The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

Ahmadi-Motamayel, Fatemeh,Shahriari, Shahriar,Goodarzi, Mohammad Taghi,Moghimbeigi, Abbas,Jazaeri, Mina,Babaei, Parisa The Korean Academy of Conservative Dentistry 2013 Restorative Dentistry & Endodontics Vol.38 No.3

Objectives: Assessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis. Materials and Methods: Thirty-six patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13. Results: The level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males. Conclusions: There was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.

The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

Fatemeh Ahmadi-Motamayel,Shahriar Shahriari,Mohammad Taghi Goodarz,Abbas Moghimbeigi,Mina Jazaeri,Parisa Babaei 大韓齒科保存學會 2013 Restorative Dentistry & Endodontics Vol.38 No.3

Objectives: Assessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis. Materials and Methods: Thirtysix patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13. Results: The level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males. Conclusions: There was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.

Potential biomarkers and signaling pathways associated with the pathogenesis of primary salivary gland carcinoma: a bioinformatics study

Bayat, Zeynab,Ahmadi-Motamayel, Fatemeh,Salimi Parsa, Mohadeseh,Taherkhani, Amir Korea Genome Organization 2021 Genomics & informatics Vol.19 No.4

Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. The most responsible genes and pathways involved in the pathology of this disorder have not been fully understood. We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. The mRNA dataset GSE153283 in the Gene Expression Omnibus database was re-analyzed for determining DEGs in cancer tissue of patients with primary SGC compared to the adjacent normal tissue (adjusted p-value < 0.001; |Log2 fold change| > 1). A protein interaction map (PIM) was built, and the main modules within the network were identified and focused on the different pathways and BP analyses. The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. A total of 137 genes were found to be differentially expressed in primary SGC. The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. TP53, EGF, FN1, NOTCH1, EZH2, COL1A1, SPP1, CDKN2A, WNT5A, PDGFRB, CCNB1, and H2AFX were demonstrated to be the most critical genes linked with the primary SGC. SPIB, FOXM1, and POLR2A significantly regulate all the hub genes. This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC.

Levels of Salivary Antioxidant Vitamins and Lipid Peroxidation in Patients with Oral Lichen Planus and Healthy Individuals

Hamidreza Abdolsamadi,Fatemeh Ahmadi-Motamayel,Nasrin Rafieian,Mohammad Taghi Goodarzi,Javad Feradmal,Seyed-Mostafa Hoseyni,Mina Jazayeri,Zahrasadat Taghavi,Poorandokht Davoodi 전남대학교 의과학연구소 2014 전남의대학술지 Vol.50 No.2

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknownetiology. Many studies have implicated the protective role of antioxidants in suchdiseases. The aim of this study was to compare salivary total antioxidant capacity (TACand malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels inpatients with erosive OLP and healthy individuals. Thirty six patients with OLP (14males, 22 females) and 36 control subjects (15 males, 21 females), matched for age andsex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidantvitamin levels were measured in both case and control groups. The salivarylevel of MDA was significantly higher (p<0.001) in patients than in controls. In patientswith OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantlydecreased in patients with OLP (p<0.001). In addition, a positive correlationwas found between the decrease in the salivary amount of vitamin C and that in vitaminE in patients and controls. In addition to the lower salivary levels of antioxidant vitaminsand the lower TAC, the higher level of MDA in patients with OLP suggests thatfree radicals and the resulting oxidative damage may be important in the pathogenesisof OLP lesions.