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RISS 인기검색어
- 검색키워드
- 저자 : Po-Yung Lai (검색결과 4 건)
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Antioxidative and Hepatoprotective Effects of Magnolol on Acetaminophen-induced Liver Damage in Rats
Yung-Hsiang Chen,Feng-Yen Lin,Po-Len Liu,Yi-Tsau Huang,Jen-Hwey Chiu,Yi-Chun Chang,Kee-Ming Man,Chuang-Ye Hong,Yen-Yi Ho,Ming-Tsung Lai 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Acute liver failure (ALF), an often fatal condition characterized by massive hepatocyte necrosis, is frequently caused by drug poisoning, particularly with acetaminophen (N-acetyl-p-aminophenol/APAP). Hepatocyte necrosis is consecutive to glutathione (GSH) depletion and mitochondrial damage caused by reactive oxygen species (ROS) overproduction. Magnolol, one major phenolic constituent of Magnolia officinalis, have been known to exhibit potent antioxidative activity. In this study, the anti-hepatotoxic activity of magnolol on APAP-induced toxicity in the Sprague-Dawley rat liver was examined. After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 μg/kg). Histological changes around the hepatic central vein, lipid peroxidation (thiobarbituric acid-reactive substance/TBARS), and GSH depletion in liver tissue induced by APAP were also recovered by magnolol treatment. The data show that oxidative stress followed by lipid peroxidation may play a very important role in the pathogenesis of APAP-induced hepatic injury; treatment with lipid-soluble antioxidant, magnolol, exerts anti-hepatotoxic activity. Our study points out the potential interest of magnolol in the treatment of toxic ALF.
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Life table of cycad scale, Aulacaspis yasumatsui (Hemiptera: Diaspididae), reared on Cycas in Taiwan
Rafique Bailey,Po-Yung Lai,Ti- Chuan Hsu,Niann-Tai Chang 한국응용곤충학회 2010 Journal of Asia-Pacific Entomology Vol.13 No.3
Aulacaspis yasumatsui Takagi (Hemiptera: Diaspididae), an invasive scale insect, attacks different species of Cycas (Cycadales: Cycadaceae) in Taiwan. Development, survival and fecundity of A. yasumatsui were studied on Cycas taitungensis at 24 °C, 70±10% RH, and a photoperiod of 12:12 (L:D) h under laboratory conditions. Data on the life history of A. yasumatsui were analyzed using the age-stage, two-sex life table, to address variable development rates among individuals and between sexes. The egg incubation time was 7.26 days for both females and males and female nymphal development duration was 28.65 days. The development duration of male nymphal stages+pupal stage was 19 days. The total pre-oviposition period (TPOP) was 35.92 days. The maximum longevity of female adults was 67 days and 1 day for males. The intrinsic rate of increase (r) was 0.100 day-1, the finite rate of increase (λ) was 1.11 day-1, the net reproduction rate (Ro) was 111.51 offspring /individual, and the mean generation time (T) was 47.24 day. Life table data can be used to project population growth, to design mass rearing programs and to establish management tactics to control insect pests.
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Rafique Bailey,Niann-Tai Chang,Po-Yung Lai 한국응용곤충학회 2011 Journal of Asia-Pacific Entomology Vol.14 No.4
Development, survival, and fecundity of the predator, Cybocephalus flavocapitis Smith, reared on its host Aulacaspis yasumatsui Takagi, were studied at 24 °C, 70±10% RH, and photoperiod of 12:12 (L:D)h under laboratory conditions. Developmental periods for egg, larval, and pupal stages were 6.4, 12.1 and 14.3 d,respectively. The mean longevity of adults was 85.1 d. Raw life history data of all individuals were pooled and analyzed according to the age-stage, two-sex life table theory. The intrinsic rate of increase (r) was 0.05 d^(−1),the finite rate of increase (λ) was 1.05 d^(−1), the net reproductive rate (R0) was 29.1 offspring, and the mean generation time (T) was 63.3 d. When we incorporated the age-stage variability of predation rate with the two-sex life table, our results indicated that the predation rates of larvae and adults were 743 eggs and 1595scales, respectively. The net predation rate of C. flavocapitis is 1874 scales. Additionally, we compared life table results of C. flavocapitis with those of a previous life table study on Cybocephalus nipponicus because both species are currently used for the biological control of A. yasumatsui in Taiwan.
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Aliou Diongue,Jeng-Tze Yang,Po-Yung Lai 한국응용곤충학회 2013 Journal of Asia-Pacific Entomology Vol.16 No.1
A morphometric study on H. armigera antenna showed four styles of sensilla, i.e., styloconica, chaetica,coeloconica, and trichodea, and their numbers were estimated. Sensilla trichodea detect inter and intraspecific communication signals and was the most numerous. They were divided into three types: type I, the longest,with a length of 34.04±3.16 μm and about 2.16 to 2.42 μm in diameter at its base; 2) type II, intermediate,with a length of 22.58±0.77 μm and basal diameter of 1.8–2.52 μm; 3) type III, the shortest sensilla trichodea,with a length of 7.62±0.4 μm and a range in diameter similar to that of type II. The length of the female sensilla trichodea was longer than that of the male. The total number of sensilla trichodea was estimated to be 7520 on the antenna of the female, and 6831 on the male antenna. The lengths of the sensilla trichodea type I and type III were significantly different on male (t=4.6881, P=0.0034) and female antenna (t=18.9852, P=0.0001). An estimation of the predicted surface area of the most numerous type I on sampled segments between the 12th and 20th segments from a female of H. armigera showed a surface area of 5×103 μm2 and a sensillar density of 38 sensilla/103 μm2. The fraction of sensilla-occupied surface area was 0.4 μm2.
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