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- 저자 : Pilloni, Andrea (검색결과 5 건)
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Giuseppina Pilloni,Leigh E. Charvet,Marom Bikson,Nikhil Palekar,Min-Jeong Kim 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.4
Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive method for stimulating the brain that is rapidly developing into a treatment method for various neurological and psychiatric conditions. In particular, there is growing evidence of a therapeutic role for tDCS in ameliorating or delaying the cognitive decline in Alzheimer’s disease (AD). We provide a brief overview of the current development and application status of tDCS as a nonpharmacological therapeutic method for AD and mild cognitive impairment (MCI), summarize the levels of evidence, and identify the improvements needed for clinical applications. We also suggest future directions for large-scale controlled clinical trials of tDCS in AD and MCI, and emphasize the necessity of identifying the mechanistic targets to facilitate clinical applications.
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Low Molecular Weight Hyaluronic Acid Enhances Osteogenesis of Adult Rat Bone Marrow Cells In Vitro
Kang, Mo K.,Jay Sison,Andrea Pilloni,Bernard, George W. Korean Academy of Oral Biology and the UCLA Dental 1998 International Journal of Oral Biology Vol.23 No.3
Hyaluronic acid is a non-sulfated glycosaminoglycan that is involved in mesenchymal cell migration, proliferation, and differentiation during early embryogenesis. Previous studies implicated the possible osteogenic role of hyaluronic acid. The purpose of our current research is to test the effects of hyaluronic acid on the osteogenesis of adult bone marrow cells in vitro. Cells harvested from the bone marrow of adult Sprague-Dawley rats were separated into two popuations based on cell density by the Ficoll-Hypaque method. Heavy density (HD) cells, consisting mainly of fibroblasts, were used to develop a semi-confluent feeder layer, onto which 3 million Light Density (LD) cells, containing the rare osteogenic stem cells of bone marrow, were seeded. Either low (160 kD) or high (1300 kD) molecular weight hyaluronic acid was added to the culture at a concentration of 0.5 mg/ml or 1.0 mg/ml. After 14 days in culture, developing bone colonies were detected by the Von Kossa staining method and were counted. The size of each bone colony was measured by a computerized digital analyzer. In the absence of hyaluronic acid, 3 bone colonies developed. When low molecullar weight HA was added at concentrations of 0.5mg/ml , 8colonies were formed, and at 1.0mg/ml 5colonies wereformed. the size of bone colonies formed in the culture treated with low molecular weight HA was also found to be larger compared to the control. However, high molecular weight HA apparently inhibited the formation of bone colonies, yielding only 1 bone colony per culture. These results demonstrate that low molecular weight HA enhances the formation and development of osteogenic colonies of adult rat bone marrow cells in vitro, but high molecular weight HA does not.
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Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds
Marini, Lorenzo,Rojas, Mariana Andrea,Sahrmann, Philipp,Aghazada, Rustam,Pilloni, Andrea Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.5
Purpose: Numerous indices have been proposed to analyse wound healing in oral soft tissues, but each has specific shortcomings. A new method of analysis, the Early Wound Healing Score (EHS), was evaluated in the present study. The aim was to assess more accurately early healing by primary intention of surgical incisions in periodontal soft tissues. Methods: Twenty-one patients were treated with different surgical procedures comprising 1 or 2 vertical releasing incisions as part of a surgical access flap. Twenty-four hours after surgery, early wound healing at the vertical releasing incisions was assessed using the EHS. This score assessed clinical signs of re-epithelialization (CSR), clinical signs of haemostasis (CSH), and clinical signs of inflammation (CSI). Since complete wound epithelialization was the main outcome, the CSR score was weighted to be 60% of the total final score. Accordingly, a score of 0, 3, or 6 points was possible for the assessment of CSR, whereas scores of 0, 1, or 2 points were possible for CSH and CSI. Higher values indicated better healing. Accordingly, the score for ideal early wound healing was 10. Results: Thirty vertical releasing incisions were assessed in 21 patients. At 24 hours after incision, 16 vertical releasing incisions (53.33%) received the maximum score of CSR, while 6 cases (20%) received an EHS of 10. None of the cases received 0 points. Conclusion: The EHS system may be a useful tool for assessing early wound healing in periodontal soft tissue by primary intention after surgery.
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Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds
Lorenzo Marini,Mariana Andrea Rojas,Philipp Sahrmann,Rustam Aghazada,Andrea Pilloni 대한치주과학회 2018 Journal of Periodontal & Implant Science Vol.48 No.5
Purpose: Numerous indices have been proposed to analyse wound healing in oral soft tissues, but each has specific shortcomings. A new method of analysis, the Early Wound Healing Score (EHS), was evaluated in the present study. The aim was to assess more accurately early healing by primary intention of surgical incisions in periodontal soft tissues. Methods: Twenty-one patients were treated with different surgical procedures comprising 1 or 2 vertical releasing incisions as part of a surgical access flap. Twenty-four hours after surgery, early wound healing at the vertical releasing incisions was assessed using the EHS. This score assessed clinical signs of re-epithelialization (CSR), clinical signs of haemostasis (CSH), and clinical signs of inflammation (CSI). Since complete wound epithelialization was the main outcome, the CSR score was weighted to be 60% of the total final score. Accordingly, a score of 0, 3, or 6 points was possible for the assessment of CSR, whereas scores of 0, 1, or 2 points were possible for CSH and CSI. Higher values indicated better healing. Accordingly, the score for ideal early wound healing was 10. Results: Thirty vertical releasing incisions were assessed in 21 patients. At 24 hours after incision, 16 vertical releasing incisions (53.33%) received the maximum score of CSR, while 6 cases (20%) received an EHS of 10. None of the cases received 0 points. Conclusion: The EHS system may be a useful tool for assessing early wound healing in periodontal soft tissue by primary intention after surgery.
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Minor Salivary Glands Calculi : An Unusual Case Found in the Hard Palate Mucosa
Roberto, Pippi,Aldo, Severi,Luig, Alo`Piero,Andrea, Pilloni,Bernard, George Korean Academy of Oral Biology and the UCLA Dental 2002 International Journal of Oral Biology Vol.27 No.2
Clinical and histological findings of a very rare case of minor salivary gland calculus located in the hard palate mucosa are presented here. Basic knowledge about minor salivary gland location and secretion are reported and some considerations of differential diagnosis of palatal swellings are explained.
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