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RISS 인기검색어
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- 저자 : Phu Huong Lan, Nguyen (검색결과 1 건)
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Phu Huong Lan, Nguyen,Le Thi Phuong, Tu,Nguyen Huu, Hien,Thuy, Le,Mather, Alison E.,Park, Se Eun,Marks, Florian,Thwaites, Guy E.,Van Vinh Chau, Nguyen,Thompson, Corinne N.,Baker, Stephen Public Library of Science 2016 PLoS neglected tropical diseases Vol.10 No.8
<▼1><P>Invasive non-typhoidal <I>Salmonella</I> (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations of iNTS disease in Asia are not well documented. We retrospectively identified >100 cases of iNTS infections in an infectious disease hospital in Southern Vietnam between 2008 and 2013. Clinical records were accessed to evaluate demographic and clinical factors associated with iNTS infection and to identify risk factors associated with death. Multi-locus sequence typing and antimicrobial susceptibility testing was performed on all organisms. Of 102 iNTS patients, 71% were HIV-infected, >90% were adults, 71% were male and 33% reported intravenous drug use. Twenty-six/92 (28%) patients with a known outcome died; HIV infection was significantly associated with death (<I>p</I> = 0.039). <I>S</I>. Enteritidis (Sequence Types (ST)11) (48%, 43/89) and <I>S</I>. Typhimurium (ST19, 34 and 1544) (26%, 23/89) were the most commonly identified serovars; <I>S</I>. Typhimurium was significantly more common in HIV-infected individuals (<I>p</I> = 0.003). Isolates from HIV-infected patients were more likely to exhibit reduced susceptibility against trimethoprim-sulfamethoxazole than HIV-negative patients (<I>p</I> = 0.037). We conclude that iNTS disease is a severe infection in Vietnam with a high mortality rate. As in sub-Saharan Africa, HIV infection was a risk factor for death, with the majority of the burden in this population found in HIV-infected adult men.</P></▼1><▼2><P><B>Author Summary</B></P><P>Invasive non-typhoidal <I>Salmonella</I> (iNTS) infections occur when <I>Salmonella</I> bacteria, which normally cause diarrhea, enter the bloodstream and spread through the body. Invasive NTS infections have become a common cause of infection and death in children with malaria and adults with HIV in sub-Saharan Africa. However, it is unknown whether iNTS is as common or as severe outside sub-Saharan Africa. We evaluated over 100 iNTS cases from an infectious disease hospital in southern Vietnam admitted between 2008–2013. We used hospital records to determine the clinical features of iNTS disease and to identify risk factors associated with death and performed typing of the isolated organisms. The majority of patients were HIV positive (72/102, 71%), >90% of patients were adults, 71% were male and 33% reported intravenous drug use. The mortality rate of iNTS patients was 28% (26/92), and HIV infection was a significant risk factor for fatal outcome (<I>p</I> = 0.039). The serovars most commonly identified were <I>S</I>. Enteritidis and <I>S</I>. Typhimurium; <I>S</I>. Typhimurium was found more frequently in HIV-positive individuals (<I>p</I> = 0.003). We report that iNTS disease is a severe infection in Vietnam with a high mortality rate. Similar to sub-Saharan Africa, HIV infection was a strong risk factor for death.</P></▼2>
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