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RISS 인기검색어
- 검색키워드
- 저자 : Perreau, Victoria M (검색결과 2 건)
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Caroline Perreau,Fabrice Desailly,Sophie Grard,Pariyarath Sangeetha Thondre,Lis Ahlstrom,Jonathan Tammam,Daniel Wils 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.10
Diabetes prevalence achieved 470B in 2021. Diabetics are looking for foods that allow them to better managethe postprandial glycemia. Owing to its large amylose fraction, pea starch may contribute to formulate recipes with a lowerglycemic index (GI). This study measured the rapidly, slowly digested and resistant fractions in pea starch and in a powdermix recipe. Starch fractions were determined according to the Englyst methodology. A nonblind repeat measure crossoverdesign trial in healthy humans was used to study the GI of pea starch and maltodextrin powder mix recipes against glucose. Gastrointestinal symptoms were measured. Thirteen healthy volunteers aged 18–60 years with body mass index <30 kg/m2 andfasting blood glucose <6.1 mmol/L participated in the study. They consumed 25 g available carbohydrate portions of the testproducts. Blood glucose was measured at -5 and 0 min before consumption till 180 min after starting to eat. The slowdigestible starch (SDS) content of native pea starch was 30% of the total starch content. The pea-based powder mix recipecontained 25% SDS in comparison with 9% for the maltodextrin-based recipe. The glucose response after pea starch wassignificantly lower compared with maltodextrin. The glucose response after pea starch recipe was significantly lower comparedwith maltodextrin recipe. There was no significant difference in mean scores for well-being and gastrointestinalsymptoms after consumption of pea starch and maltodextrin or between the two recipes. In conclusion, this study hasdemonstrated the presence of high SDS content in pea starch, which reduced postprandial glycemic response compared withmaltodextrin. The pea starch recipe did not induce any negative gastrointestinal symptoms. Pea starch may, therefore, prove tobe a beneficial ingredient in developing food products for improving glycemic control without undesirable side effects.
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Axonal mRNA in uninjured and regenerating cortical mammalian axons.
Taylor, Anne M,Berchtold, Nicole C,Perreau, Victoria M,Tu, Christina H,Li Jeon, Noo,Cotman, Carl W The Society 2009 The Journal of neuroscience Vol.29 No.15
<P>Using a novel microfluidic chamber that allows the isolation of axons without contamination by nonaxonal material, we have for the first time purified mRNA from naive, matured CNS axons, and identified the presence of >300 mRNA transcripts. We demonstrate that the transcripts are axonal in nature, and that many of the transcripts present in uninjured CNS axons overlap with those previously identified in PNS injury-conditioned DRG axons. The axonal transcripts detected in matured cortical axons are enriched for protein translational machinery, transport, cytoskeletal components, and mitochondrial maintenance. We next investigated how the axonal mRNA pool changes after axotomy, revealing that numerous gene transcripts related to intracellular transport, mitochondria and the cytoskeleton show decreased localization 2 d after injury. In contrast, gene transcripts related to axonal targeting and synaptic function show increased localization in regenerating cortical axons, suggesting that there is an increased capacity for axonal outgrowth and targeting, and increased support for synapse formation and presynaptic function in regenerating CNS axons after injury. Our data demonstrate that CNS axons contain many mRNA species of diverse functions, and suggest that, like invertebrate and PNS axons, CNS axons synthesize proteins locally, maintaining a degree of autonomy from the cell body.</P>
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