Anomalous Ambipolar Transport of Organic Semiconducting Crystals via Control of Molecular Packing Structures

Park, Beomjin,Kim, Kyunghun,Park, Jaesung,Lim, Heeseon,Lanh, Phung Thi,Jang, A-Rang,Hyun, Chohee,Myung, Chang Woo,Park, Seungkyoo,Kim, Jeong Won,Kim, Kwang S.,Shin, Hyeon Suk,Lee, Geunsik,Kim, Se Hyun American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.33

<P>Organic crystals deposited on 2-dimensional (2D) van der Waals substrates have been widely investigated due to their unprecedented crystal structures and electrical properties. van der Waals interaction between organic molecules and the substrate induces epitaxial growth of high quality organic crystals and their anomalous crystal morphologies. Here, we report on unique ambipolar charge transport of a 'lying-down' pentacene crystal grown on a 2D hexagonal boron nitride van der Waals substrate. From in-depth analysis on crystal growth behavior and ultraviolet photoemission spectroscopy measurement, it is revealed that the pentacene crystal at the initial growth stage have a lattice-strained packing structure and unique energy band structure with a deep highest occupied molecular orbital level compared to conventional 'standing-up' crystals. The lattice-strained pentacene few layers enable ambipolar charge transport in field-effect transistors with balanced hole and electron field-effect mobilities. Complementary logic circuits composed of the two identical transistors show clear inverting functionality with a high gain up to 15. The interesting crystal morphology of organic crystals on van der Waals substrates is expected to attract broad attentions on organic/2D interfaces for their electronic applications.</P>

Utilization of a Clinical Trial Management System for the Whole Clinical Trial Process as an Integrated Database: System Development

Park, Yu Rang,Yoon, Young Jo,Koo, HaYeong,Yoo, Soyoung,Choi, Chang-Min,Beck, Sung-Ho,Kim, Tae Won JMIR Publications 2018 Journal of medical Internet research Vol.20 No.4

<P><B>Background</B></P><P>Clinical trials pose potential risks in both communications and management due to the various stakeholders involved when performing clinical trials. The academic medical center has a responsibility and obligation to conduct and manage clinical trials while maintaining a sufficiently high level of quality, therefore it is necessary to build an information technology system to support standardized clinical trial processes and comply with relevant regulations.</P><P><B>Objective</B></P><P>The objective of the study was to address the challenges identified while performing clinical trials at an academic medical center, Asan Medical Center (AMC) in Korea, by developing and utilizing a clinical trial management system (CTMS) that complies with standardized processes from multiple departments or units, controlled vocabularies, security, and privacy regulations.</P><P><B>Methods</B></P><P>This study describes the methods, considerations, and recommendations for the development and utilization of the CTMS as a consolidated research database in an academic medical center. A task force was formed to define and standardize the clinical trial performance process at the site level. On the basis of the agreed standardized process, the CTMS was designed and developed as an all-in-one system complying with privacy and security regulations.</P><P><B>Results</B></P><P>In this study, the processes and standard mapped vocabularies of a clinical trial were established at the academic medical center. On the basis of these processes and vocabularies, a CTMS was built which interfaces with the existing trial systems such as the electronic institutional review board health information system, enterprise resource planning, and the barcode system. To protect patient data, the CTMS implements data governance and access rules, and excludes 21 personal health identifiers according to the Health Insurance Portability and Accountability Act (HIPAA) privacy rule and Korean privacy laws. Since December 2014, the CTMS has been successfully implemented and used by 881 internal and external users for managing 11,645 studies and 146,943 subjects.</P><P><B>Conclusions</B></P><P>The CTMS was introduced in the Asan Medical Center to manage the large amounts of data involved with clinical trial operations. Inter- and intraunit control of data and resources can be easily conducted through the CTMS system. To our knowledge, this is the first CTMS developed in-house at an academic medical center side which can enhance the efficiency of clinical trial management in compliance with privacy and security laws.</P>

Development of a Knowledge Base for Korean Pharmacogenomics Research Network

Park, Chan Hee,Lee, Su Yeon,Jung, Yong,Park, Yu Rang,Lee, Hye Won,Kim, Ju Han Korea Genome Organization 2005 Genomics & informatics Vol.3 No.3

Pharmacogenomics research requires an intelligent integration of large-scale genomic and clinical data with public and private knowledge resources. We developed a web-based knowledge base for KPRN (Korea Pharmacogenomics Research Network, http://kprn.snubi. org/). Four major types of information is integrated; genetic variation, drug information, disease information, and literature annotation. Eighteen Korean pharmacogenomics research groups in collaboration have submitted 859 genotype data sets for 91 disease-related genes. Integrative analysis and visualization of the large collection of data supported by integrated biomedical path­ways and ontology resources are provided with a user-friendly interface and visualization engine empowered by Generic Genome Browser.

Prediction of Microbial Infection of Cultured Cells Using DNA Microarray Gene-Expression Profiles of Host Responses

Park, Yu Rang,Chung, Tae Su,Lee, Young Joo,Song, Yeong Wook,Lee, Eun Young,Sohn, Yeo Won,Song, Sukgil,Park, Woong Yang,Kim, Ju Han The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.10

<P>Infection by microorganisms may cause fatally erroneous interpretations in the biologic researches based on cell culture. The contamination by microorganism in the cell culture is quite frequent (5% to 35%). However, current approaches to identify the presence of contamination have many limitations such as high cost of time and labor, and difficulty in interpreting the result. In this paper, we propose a model to predict cell infection, using a microarray technique which gives an overview of the whole genome profile. By analysis of 62 microarray expression profiles under various experimental conditions altering cell type, source of infection and collection time, we discovered 5 marker genes, <I>NM_005298</I>, <I>NM_016408</I>, <I>NM_014588</I>, <I>S76389</I>, and <I>NM_001853</I>. In addition, we discovered two of these genes, <I>S76389</I>, and <I>NM_001853</I>, are involved in a <I>Mycolplasma</I>-specific infection process. We also suggest models to predict the source of infection, cell type or time after infection. We implemented a web based prediction tool in microarray data, named Prediction of Microbial Infection (http://www.snubi.org/software/PMI).</P>

Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity

Park, Jin Hyoung,Noh, Soo Min,Woo, Ju Rang,Kim, Jong Won,Lee, Gyun Min WILEY‐VCH Verlag 2016 BIOTECHNOLOGY JOURNAL Vol.11 No.4

<P><B>Abstract</B></P><P>To find a more effective chemical reagent for improved monoclonal antibody (mAb) production, eight chemical reagents (curcumin, quercein, DL‐sulforaphane, thymidine, valeric acid, phenyl butyrate, valproic acid, and lithium chloride) known to induce cell cycle arrest were examined individually as chemical additives to recombinant CHO (rCHO) cell cultures producing mAb. Among these chemical additives, valeric acid showed the best production performance. Valeric acid decreased specific growth rate (μ), but increased culture longevity and specific mAb productivity (<I>q</I><SUB>mAb</SUB>) in a dose‐dependent manner. The beneficial effect of valeric acid on culture longevity and <I>q</I><SUB>mAb</SUB> outweighed its detrimental effect on μ, resulting in 2.9‐fold increase in the maximum mAb concentration when 1.5 mM valeric acid was added to the cultures. Furthermore, valeric acid did not negatively affect the mAb quality attributes with regard to aggregation, charge variation, and galactosylation. Unexpectedly, galactosylation of the mAb increased by the 1.5 mM valeric acid addition. Taken together, the results obtained here demonstrate that valeric acid is an effective chemical reagent to increase mAb production in rCHO cells.</P>

Establishment of Pest Forecasting Management System for the Improvement of Pass Ratio of Korean Exporting Pears

Park, Joong Won,Park, Jeong Sun,Kang, Ah Rang,Na, In Seop,Cha, Gwang Hong,Oh, Hwan Jung,Lee, Sang Hyun,Yang, Kwang Yeol,Kim, Wol Soo,Kim, Iksoo Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.2

A decrease in pass ratio of Korean exporting pears causes several negative effects including an increase in pesticide dependency. In this study, we attempted to establish the pest forecasting management system, composed of weekly field forecasting by pear farmers, meteorological data obtained by automatic weather station (AWS), newly designed internet web page ($\underline{http://pearpest.jnu.ac.kr/}$) as information collecting and providing ground, and information providing service. The weekly field forecasting information on major pear diseases and pests was collected from the forecasting team composed of five team leaders from each pear exporting complex. Further, an abridged weather information for the prediction of an infestation of major disease (pear scab) and pest (pear psylla and scale species) was obtained from an AWS installed at Bonghwang in Naju City. Such information was then promptly uploaded on the web page and also publicized to the pear famers specializing in export. We hope this pest forecasting management system increases the pass ratio of Korean exporting pears throughout establishment of famer-oriented forecasting, inspiring famers' effort for the prevention and forecasting of diseases and pests occurring at pear orchards.

Clinical and Hematological Effects of Tocilizumab on Serum Hepcidin, Anemia Response and Disease Activity in Patients with Active Rheumatoid Arthritis

Park, Ki-Jeong,Jin, Hye-Mi,Cho, Young-Nan,Kang, Jeong-Hwa,Jung, Hyun-Ju,Kang, Ji-Hyoun,Kim, Ji-Eun,Yim, Yi-Rang,Lee, Jeong-Won,Lee, Kyung-Eun,Park, Dong-Jin,Kim, Tae-Jong,Lee, Shin-Seok,Kee, Seung-Jun 대한류마티스학회 2016 대한류마티스학회지 Vol.23 No.1

A Case of Hypothyroidism and Type 2 Diabetes Associated with Type V Hyperlipoproteinemia and Eruptive Xanthomas

Park Jeong Rang,Jung Tae Sik,Jung Jung Hwa,Lee Gyeong Won,Kim Me Ae,Park Ki Jong,김덕룡,장세호,Chung Soon Il,Hahm Jong Ryeal 대한의학회 2005 Journal of Korean medical science Vol.20 No.3

Primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. To date, there have been only a few case reports of type 2 diabetes patients with both type V hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. We report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type V hyperlipoproteinemia and eruptive xanthomas. We found rouleaux formation of RBCs in peripheral blood smear, elevated TSH, and low free T4 level, and dyslipidemia (total cholesterol 18.1 mM/L, triglyceride 61.64 mM/L, HDL 3.0 mM/L, and LDL 2.54 mM/L). She has taken fenofibrate, levothyroxine, and oral hypoglycemic agent for 4 months. After treatment, both TSH level and lipid concentration returned to normal range, and her yellowish skin nodules have also disappeared.

Caspase 9 promoter polymorphisms and risk of primary lung cancer

Park, Jae Yong,Park, Jung Min,Jang, Jin Sung,Choi, Jin Eun,Kim, Kyung Mee,Cha, Sung Ick,Kim, Chang Ho,Kang, Young Mo,Lee, Won Kee,Kam, Sin,Park, Rang Woon,Kim, In San,Lee, Jae-Tae,Jung, Tae Hoon IRL Press 2006 Human molecular genetics Vol.15 No.12

<P>Caspase-9 (CASP-9) is an initiator CASP in the apoptosome-driven apoptosis pathway and plays an important role in the development and progression of cancer. Polymorphisms in the promoter region of the <I>CASP-9</I> gene may influence the promoter activity of this gene, thereby modulating susceptibility to lung cancer. To test this hypothesis, we examined the association of four polymorphisms [−1263A>G, −905T>G, −712C>T and −293_−275delCGTGAGGTCAGTGCGGGGA (−293del)] in the <I>CASP-9</I> promoter with the risk of lung cancer in a Korean population. The <I>CASP-9</I> genotypes were determined in 432 lung cancer patients and 432 healthy controls that were frequency-matched for age and gender. The −1263 GG genotype was associated with a significantly decreased risk of lung cancer compared with the −1263 AA genotype or combined −1263 AA+AG genotype [adjusted odds ratio (OR)=0.64, 95% confidence interval (95% CI)=0.42–0.98, <I>P</I>=0.04 and adjusted OR=0.67, 95% CI=0.46–0.97, <I>P</I>=0.01, respectively]. For the −712C>T polymorphism, individuals with at least one −712T allele were at a significantly increased risk of lung cancer compared with those harboring the −712 CC genotype (adjusted OR=1.42, 95% CI=1.06–1.89, <I>P</I>=0.02). Consistent with the results of genotype analyses, the −1263G/−712C (G-C) haplotype was associated with a significantly decreased risk of lung cancer [adjusted OR=0.59, 95% CI=0.47–0.75, <I>P</I> and Bonferroni corrected <I>P</I> (<I>P</I><SUB>c</SUB>)<0.001]. Moreover, the risk of lung cancer decreased in a dose-dependent manner as the number of the G-C haplotypes increased (adjusted OR=0.60, 95% CI=0.45–0.81, <I>P</I>=0.0007 and <I>P</I><SUB>c</SUB>=0.0014 for the G-C heterozygotes and adjusted OR=0.34, 95% CI=0.17–0.68, <I>P</I>=0.0023 and <I>P</I><SUB>c</SUB>=0.0046 for the G-C homozygotes; <I>P</I><SUB>trend</SUB><0.001). The promoter assay revealed the G-C haplotype to have a significantly higher promoter activity than the −1263G/−712T and −1263A/−712C haplotypes. These results suggest that <I>CASP-9</I> promoter polymorphisms affect <I>CASP-9</I> expression and contribute to genetic susceptibility to lung cancer.</P>

GOChase-II: correcting semantic inconsistencies from Gene Ontology-based annotations for gene products

Park, Yu Rang,Kim, Jihun,Lee, Hye Won,Yoon, Young Jo,Kim, Ju Han BioMed Central 2011 BMC bioinformatics Vol.12 No.suppl1

<P><B>Background</B></P><P>The Gene Ontology (GO) provides a controlled vocabulary for describing genes and gene products. In spite of the undoubted importance of GO, several drawbacks associated with GO and GO-based annotations have been introduced. We identified three types of semantic inconsistencies in GO-based annotations; semantically redundant, biological-domain inconsistent and taxonomy inconsistent annotations.</P><P><B>Methods</B></P><P>To determine the semantic inconsistencies in GO annotation, we used the hierarchical structure of GO graph and tree structure of NCBI taxonomy. Twenty seven biological databases were collected for finding semantic inconsistent annotation.</P><P><B>Results</B></P><P>The distributions and possible causes of the semantic inconsistencies were investigated using twenty seven biological databases with GO-based annotations. We found that some evidence codes of annotation were associated with the inconsistencies. The numbers of gene products and species in a database that are related to the complexity of database management are also in correlation with the inconsistencies. Consequently, numerous annotation errors arise and are propagated throughout biological databases and GO-based high-level analyses. GOChase-II is developed to detect and correct both syntactic and semantic errors in GO-based annotations.</P><P><B>Conclusions</B></P><P>We identified some inconsistencies in GO-based annotation and provided software, GOChase-II, for correcting these semantic inconsistencies in addition to the previous corrections for the syntactic errors by GOChase-I.</P>