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임장현(Janghyun Lim),박은혜(Eunhye Park) 한국컴퓨터게임학회 2017 한국컴퓨터게임학회논문지 Vol.30 No.3
Literacy skill is an essential element in promoting the educational outcomes and social participation of students with disabilities. A variety of apps that are effective in teaching students with disabilities have been launched and are being used effectively. This study investigates literacy instruction apps for children with disabilities to enhance the possibility of future app development and educational application. 7 iOS-based apps, 7 android-based apps, 14 apps in total were analyzed, and assessed by program category, learning objectives, and evaluation criteria. In addition to analysis results, implications of research and implications for app selection were suggested.
Lee, Janghyun,Park, Eun-Byeol,Min, Jiyoun,Sung, Si-Eun,Jang, Yejin,Shin, Jin Soo,Chun, Dongmin,Kim, Ki-Hun,Hwang, Jihyun,Lee, Mi-Kyung,Go, Yun Young,Kwon, Dohyeong,Kim, Meehyein,Kang, Suk-Jo,Choi, Byo Oxford University Press 2018 Nucleic acids research Vol.46 No.4
<P><B>Abstract</B></P><P>Retinoic acid-inducible gene I (RIG-I) recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5′ phosphates. A few reports of 5′-PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5′-triphosphate moiety. Here, we report that non-canonical synthetic RNA oligonucleotides containing G-U wobble base pairs that form a bent helix can exert RIG-I-mediated antiviral and anti-tumor effects in a sequence- and site-dependent manner. We present synthetic RNAs that have been systematically modified to enhance their efficacy and we outline the basic principles for engineering RIG-I agonists applicable to immunotherapy.</P>