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An Aggressive Large Epithelioid Hemangioendothelioma of the Anterior Mediastinum in a Young Woman
Roman Dutta,Harish Pal,Garima Garg,Sambit Mohanty 대한흉부외과학회 2018 Journal of Chest Surgery (J Chest Surg) Vol.51 No.6
Hemangioendothelioma is a rare vascular tumor with involvement of the liver, brain, long bones, and lung. Among the 6 histological subtypes, epithelioid hemangioendothelioma (EHE) is the most aggressive. Its occurrence in the mediastinum is quite rare, and very few cases have been documented. The reported cases in the literature have described difficulties in the preoperative diagnosis due to the unusual histological appearance of the tumor. Immunohistochemistry remains the mainstay for a definitive diagnosis. Due to its low incidence, there is no standard treatment for mediastinal EHE, but curative resection is the preferred treatment option where possible, with chemotherapy used as an adjuvant treatment or in cases of widespread inoperable disease. The present case study describes an aggressive EHE occurring in an 18-year-old woman in the anterior mediastinum.
Sujitha D.,Kumar H. G. Jalendra,Thapliayal Garima,Pal Garima,Vanitha P. A.,Uttarkar Akshay,Patil Mahesh,Reddy B. H. Rajashekar,Niranjan Vidya,Rayalcheruvu Usha,Govind Geetha,Udayakumar M.,Vemanna Ramu 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.6
Reactive oxygen species (ROS) increases under stress and damages cellular processes leading to decrease in productivity. Many genes have been known to be involved in scavenging ROS. We report the identification of master regulators of oxidative stress responsive genes from contrasting rice genotypes. Using microarray analysis, we identified 52 differentially expressed transcription factors (TFs) from the contrasting rice genotypes under oxidative stress. Upregulation of these TFs induces the expression of many genes in resistant or sensitive genotypes. The promoters of these TFs are enriched with reactive oxygen species binding elements (ROSE). The promoter analysis of genes that respond to oxidative stress also revealed that these TF binding sites were present and that these genes expressed differently in contrasting rice genotypes. The transcript levels of TFs correlate with expression level of stress responsive genes coding for various pathways such as polyol, ABA, JA biosynthesis and signaling. Functional validation of HSF-C1a using virus-induced gene silencing (VIGS), showed reduced expression of its target genes. Our study demonstrates that identified TFs could act as major transcriptional regulators of oxidative stress tolerance. These TFs can be used as markers and are potential candidates to improve stress tolerance in plants.