Evaluation of the analgesic and anti-inflammatory properties of methanolextract of Artanema sesamoides Benth roots in animal models

Malaya Gupta,UK Mazumder,V Thamil Selvan,L Manikandan,Senthilkumar GP,R Suresh,P Gomathi,B Ashok Kumar 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.2

The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity. The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity.

A superior dye adsorbent towards the hydrogen evolution reaction combining active sites and phase-engineering of (1T/2H) MoS₂/α-MoO₃ hybrid heterostructured nanoflowers

Manikandan, Arumugam,Ilango, P. Robert,Chen, Chia-Wei,Wang, Yi-Chung,Shih, Yu-Chuan,Lee, Ling,Wang, Zhiming M.,Ko, Hyunhyub,Chueh, Yu-Lun The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.31

<P>Here, we demonstrate the successful synthesis of (1T/2H) MoS2/α-MoO3 heterostructured nanoflowers at a low temperature of 200 °C by a one-step hydrothermal method. By tuning the reaction time under the influence of thiourea and hydrazine hydrate, we established a complete phase-engineered MoS2 with 1T and 2H phases on the surface of α-MoO3. Active sites associated with the phase-engineered (1T/2H) MoS2/α-MoO3 hybrid nanoflowers enable them to exhibit dual roles as a superior dye adsorbent and an electrocatalyst towards the hydrogen evolution reaction. The 2H-rich (1T/2H) MoS2/α-MoO3 hybrid heterostructured nanoflowers prepared at 16 h achieved a high surface area of 37.97 m<SUP>2</SUP> g<SUP>−1</SUP>, and 97% of the RhB dye with an initial concentration of 47.9 mg L<SUP>−1</SUP> was removed within 10 min through the adsorption process, which is the highest known removal efficiency reported in the literature. As a hydrogen evolution reaction (HER) electrocatalyst in acidic solution, the 1T-rich (1T/2H) MoS2/α-MoO3 hybrid heterostructured nanoflowers prepared at 12 h exhibited a highly efficient catalytic activity by achieving a low overpotential of 232 mV at a current density of 10 mA cm<SUP>−2</SUP>, which is comparable to those of previously reported HER catalysts based on MoS2. Moreover, this sample reached a low Tafel slope of 81 mV dec<SUP>−1</SUP> and was stable when operated for more than 1000 cycles.</P>

Stiffening evaluation of flat elements towards stiffened elements under axial compression

Manikandan, P.,Arun, N. Techno-Press 2018 Advances in computational design Vol.3 No.1

Thin-walled cross-sections can be optimized to enhance their resistance and progress their behaviour, leading to more competent and inexpensive structural system. The aim of this study is to afford a methodology that would facilitate progress of optimized cold formed steel (CFS) column section with maximum ultimate strength for practical applications. The proposed sections are designed to comply with the geometrical standards of pre-qualified column standards for CFS structures as well as with the number of industrialized and practical constraints. The stiffening evaluation process of CFS lipped channel columns, a five different cross section are considered. The experimental strength and behaviour of the proposed sections are verified by using the finite element analysis (FEA). A series comprehensive parametric study is carried out covering a wide range of section slenderness and overall slenderness ratio of the CFS column with and without intermediate web stiffeners. The ultimate strength of the sections is determined based on the Direct Strength Specification and other design equation available from the literature for CFS structures. A modified design method is proposed for the DSM specification. The results indicate that the CFS column with complex edge and intermediate web stiffeners provides an ultimate strength which is up to 78% higher than standard optimized shapes with the same amount of cross sectional area.

Hybrid solid electrolyte with the combination of Li7La3Zr2O12 ceramic and ionic liquid for high voltage pseudo-solid-state Li-ion batteries

Kim, H.,Manikandan, P.,Lim, Y.,Kim, J.,Nam, S. c.,Kim, Y. Royal Society of Chemistry 2016 Journal of Materials Chemistry A Vol.4 No.43

<P>Concerning the safety aspects of high-voltage Li-ion batteries, a pelletized hybrid solid electrolyte (HSE) was prepared by blending Li7La3Zr2O12 (LLZO) ceramic particles and an ionic liquid electrolyte (ILE) for use in pseudo-solid-state Li-ion batteries. The LLZO particles are enclosed by the ionic liquid as a LLZO-ILE matrix, and are quantified by FESEM elemental mapping. The chemical stability of the LLZO in the ILE is confirmed by powder XRD and FT-IR analysis. The HSE, with an optimized weight ratio of 80% LLZO, 19% Py14TFSI, and 1% lithium bis(trifluoromethanesulfonyl) imide, exhibits good thermal stability, even at 400 degrees C. The optimized HSE reveals an ionic conductivity of 0.4 x 10(-3) S cm(-1) and an electrochemical stability of 5.5 V with Li metal. Pseudo-solid-state Li-ion cells are fabricated using the HSE, and afford initial charge-discharge capacities of 140/130 mA h g(-1) (Li/HSE/LiCoO2) with 99% capacity retention at the 150th cycle. The scope of the HSE is widened to high-voltage (>8 V) pseudo-solid-state Li-ion batteries through a bipolar stacked cell design. Dendrite formation is hindered during cycling in the Li-ion cell. Hence, the present investigation will greatly contribute to the next generation of high-voltage pseudo-solid-state Li-ion batteries.</P>

Effect of stiffened element and edge stiffener in strength and behaviour of cold formed steel built-up beams

Manikandan, P.,Sukumar, S. Techno-Press 2016 Advances in computational design Vol.1 No.2

The aim of this study is to investigate the effect of stiffened element and edge stiffener in the behaviour and flexural strength of built-up cold-formed steel beams. An experimental and analytical analysis of CFS channel sections in four different geometries is conducted, including simple channel sections, a stiffened channel section with or without edge stiffeners. Nonlinear finite element models are developed using finite element analysis software package ANSYS. The FEA results are verified with the experimental results. Further, the finite element model is used for parametric studies by varying the depth, thickness, and the effect of stiffened element, edge stiffener and their interaction with compression flanges on stiffened built-up cold-formed steel beams with upright edge stiffeners. In addition, the flexural strength predicted by the finite element analysis is compared with the design flexural strength calculated by using the North American Iron and Steel Institute Specifications for cold-formed steel structures (AISI: S100-2007) and suitable suggestion is made.

Behaviour of Stiffened Cold-Formed Steel Built-up Sections with Complex Edge Stiffeners under Bending

P. Manikandan,S. Sukumar 대한토목학회 2015 KSCE Journal of Civil Engineering Vol.19 No.7

This paper is concerned with the effect of stiffened element at the flange/web junction and complex edge stiffener in behaviour and strength of built-up cold-formed steel flexural members. An extensive experimental investigation and a finite element analysis of stiffened built-up cold-formed beam sections with complex stiffeners under two point loading is presented. A nonlinear finite element model is developed and verified against test results. All the results are compared with the design strength calculated using the North American Iron and Steel Institute Specification for cold-formed steel structures (AISI: S100, 2007). Following the validation, an extensive finite element parametric study is conducted to study the influences of a range of parameters, and the results are compared with the nominal design strength by AISI: S100 (2007) and suitable recommendation are made.

Contribution to the development of tiles made of paper board sludge

Velumani, P.,Manikandan, P. Techno-Press 2020 Advances in environmental research Vol.9 No.4

Growth of any country rest in the consumption of industrial wastes for its infrastructure amenities. Countries like India positively desires a vital utilization of industrial waste resembling paper sludge in the construction industry to make various building materials. Also, it is the duty of all civil engineers or researchers to attach them in mounting new materials from the waste dumped as land fillings. In every construction project, about 70% of cost accounts for the procurement of materials. If this, can be minimized consequently the cost of construction will certainly be condensed. Research has established that the waste paper sludge can be reused in the construction field for a probable scope. The construction diligences munch through a massive quantity of non-renewable resources. On the additional dispense, more waste paper board sludge ends up in landfills or dumpsites than those recycled. Consequently, waste paper sludge for use as a construction material composes a step towards sustainable development. Keeping this in mind an endeavor has been made to utilize paper board sludge acquired from the paper board industry and used with several pozzolanic and cementitious materials for a specific purpose. The addition of paper sludge has been varied from 0% to 20% by weight of cement. The tests done with the samples expose that four samples showed significant outcomes with remarkable strength and durability properties which guide to move for the next phase of research for producing lightweight tiles.

Effect of rare earth dopants on the radiation shielding properties of barium tellurite glasses

P. Vani,G. Vinitha,M.I. Sayyed,Maha M. AlShammari,N. Manikandan 한국원자력학회 2021 Nuclear Engineering and Technology Vol.53 No.12

Rare earth doped barium tellurite glasses were synthesised and explored for their radiation shieldingapplications. All the samples showed good thermal stability with values varying between 101 C and135 C based on dopants. Structural properties showed the dominance of matrix elements compared torare earth dopants in forming the bridging and non-bridging atoms in the network. Bandgap valuesvaried between 3.30 and 4.05 eV which was found to be monotonic with respective rare earth dopantsindicating their modification effect in the network. Various radiation shielding parameters like linearattenuation coefficient, mean free path and half value layer were calculated and each showed the effectof doping. For all samples, LAC values decreased with increase in energy and is attributed to photoelectricmechanism. Thulium doped glasses showed the highest value of 1.18 cm1 at 0.245 MeV for 2 mol.%doping, which decreased in the order of erbium, holmium and the base barium tellurite glass, while halfvalue layer and mean free paths showed an opposite trend with least value for 2 mol.% thulium indicating that thulium doped samples are better attenuators compared to undoped and other rare earthdoped samples. Studies indicate an increased level of thulium doping in barium tellurite glasses can leadto efficient shielding materials for high energy radiation.

Comparative Study of Two Congestion Management Methods for the Restructured Power Systems

Manikandan, B.V.,Raja, S. Charles,Venkatesh, P.,Mandala, Manasarani The Korean Institute of Electrical Engineers 2011 Journal of Electrical Engineering & Technology Vol.6 No.3

Congestion management is one of the most challenging tasks of a system operator to ensure the operation of transmission system within operating limits. In this paper, cluster/zone method and relative electrical distance (RED) method for congestion management are compared based on the considered parameters. In the cluster/zone method, rescheduling of generation is based on user impact on congestion through the use of transmission congestion distribution factors. In the RED method, the desired proportions of generations for the desired overload relieving are obtained. Even after generation rescheduling, if congestion exists, load curtailment option is also introduced. Rescheduling cost, system cost, losses, and voltage stability parameter are also calculated and compared for the above two methods of congestion management. The results are illustrated on sample 6-bus, IEEE 30-bus, and Indian utility 69-bus systems.

Available Transfer Capability Enhancement with FACTS Devices in the Deregulated Electricity Market

Manikandan, B.V.,Raja, S. Charles,Venkatesh, P. The Korean Institute of Electrical Engineers 2011 Journal of Electrical Engineering & Technology Vol.6 No.1

In order to facilitate the electricity market operation and trade in the restructured environment, ample transmission capability should be provided to satisfy the demand of increasing power transactions. The conflict of this requirement and the restrictions on the transmission expansion in the restructured electricity market has motivated the development of methodologies to enhance the available transfer capability (ATC) of existing transmission grids. The insertion of flexible AC transmission System (FACTS) devices in electrical systems seems to be a promising strategy to enhance single area ATC and multi-area ATC. In this paper, the viability and technical merits of boosting single area ATC and multi-area ATC using Thyristor controlled series compensator (TCSC), static VAR compensator (SVC) and unified power flow controller (UPFC) in single device and multi-type three similar and different device combinations are analyzed. Particle swarm optimization (PSO) algorithm is employed to obtain the optimal settings of FACTS devices. The installation cost is also calculated. The study has been carried out on IEEE 30 bus and IEEE 118 bus systems for the selected bilateral, multilateral and area wise transactions.