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        Distribution of Active and Resting Periods in the Motor Activity of Patients with Depression and Schizophrenia

        Ole Bernt Fasmer,Erik Hauge,Jan Øystein Berle,Steven Dilsaver,Ketil J. Oedegaard 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1

        ObjectiveaaAlterations of activity are prominent features of the major functional psychiatric disorders. Motor activity patterns are characterized by bursts of activity separated by periods with inactivity. The purpose of the present study has been to analyze such active and inactive periods in patients with depression and schizophrenia. MethodsaaActigraph registrations for 12 days from 24 patients with schizophrenia, 23 with depression and 29 healthy controls. ResultsaaPatients with schizophrenia and depression have distinctly different profiles with regard to the characterization and distribution of active and inactive periods. The mean duration of active periods is lowest in the depressed patients, and the duration of inactive periods is highest in the patients with schizophrenia. For active periods the cumulative probability distribution, using lengths from 1 to 35 min, follows a straight line on a log-log plot, suggestive of a power law function, and a similar relationship is found for inactive periods, using lengths from 1 to 20 min. For both active and inactive periods the scaling exponent is higher in the depressed compared to the schizophrenic patients. ConclusionaaThe present findings add to previously published results, with other mathematical methods, suggesting there are important differences in control systems regulating motor behavior in these two major groups of psychiatric disorders.

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        Motor Activity in Adult Patients with Attention Deficit Hyperactivity Disorder

        Ole Bernt Fasmer,Kristin Mjeldheim,Wenche Førland,Anita L. Hansen,Steven Dilsaver,Ketil J. Oedegaard,Jan Øystein Berle 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.4

        ObjectiveaaHyperactivity is a core symptom of attention-deficit hyperactivity disorder (ADHD), but limited information is available on analysis of activity patterns in this disorder. The aim of the study was to analyze motor activity during daily living in adult patients with ADHD. MethodsaaPatients (n=76) from the private psychiatric practice of two of the authors were recruited, and were compared to patients with other psychiatric disorders and to normal controls. Actigraphs were used to record motor activity for six days, with one minute intervals, and data were analysed using linear and non-linear mathematical methods. ResultsaaFor short recording periods (300 minutes) the activity levels of ADHD patients do not differ from normal controls, but the autocorrelation (lag 1) is lower and Fourier analysis shows higher power in the high frequency range, corresponding to the period from 2–8 min. During recordings for six days there are no significant differences between ADHD patients and the control groups. The combined and inattentive subgroups differ only in the six days recordings. The Fourier analyses show that the combined type has lower power in the high frequency range, corresponding to the period from 4–8 hours, and in the analysis of rhythms the intra-daily variability is lower, compared to the inattentive type. ConclusionaaAdult ADHD patients do not show evidence of hyperactivity, but have levels of activity similar to normal controls. However, on several measures ADHD patients display altered activity patterns, indicating that the regulation of motor activity in this disorder is different from controls.

      • KCI등재후보

        A Naturalistic Study of the Effect of Acupuncture on Heart-Rate Variability

        Ole Bernt Fasmer,Yong Huang,Hanbo Liao,Jan Øystein Berle,Junxian Wu,Ketil Joachim Oedegaard,Gustav Wik,Zhangjin Zhang 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.1

        Objectives: To study the effect of acupuncture on heart rate variability (HRV) by using linear and non-linear methods of analysis. Methods: 40 patients were recruited consecutively, including patients with insomnia, stomachache,diarrhea, dizziness, cervical syndrome, lower back pain, gonarthritis, peripheral facial paralysis, post-traumatic organic brain syndrome and urinary retention. Different acupoint prescriptions were used, according to the textbook for 5-years’ education on traditional Chinese medicine specialty, which is used in Chinese Universities. HRV was recorded before,during, and after acupuncture. Results: Acupuncture substantially reduced variability, causing a 41% reduction in the standard deviation. Using a Fourier analysis, the variances both in the low frequency (LF) and the high frequency (HF) ranges were markedly reduced, but the LF/HF ratio (an indication of sympathovagal balance) was not altered. The HR was unchanged. The sample entropy, which is a measure of the complexity of time series, was significantly increased (þ35%). Conclusions: Acupuncture produced a pattern of changes different from that seen in pathological conditions, where increased variability and reduced complexity is expected.

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