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1
Non-deformable support system application at tunnel-34 of Ankara-Istanbul high speed railway project

C.O. Aksoy,G.G. Uyar,E. Posluk,K. Ogul,I. Topal,K. Kucuk 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.5
- 복사/대출신청
Non-Deformable Support System (NDSS) is one of the support system analysis methods. It is likely seen as numerical analysis. Obviously, numerical modeling is the key tool for this system but not unique. Although the name of the system makes you feel that there is no deformation on the support system, it is not true. The system contains some deformation but in certain tolerance determined by the numerical analyses. The important question is what is the deformation tolerance? Zero deformation in the excavation environment is not the case, actually. However, deformation occurred after supporting is important. This deformation amount will determine the performance of the applied support. NDSS is a stronghold analysis method applied in full to make this work. While doing this, NDSS uses the properties of rock mass and material, various rock mass failure criteria, various material models, different excavation geometries, like other methods. The thing that differ NDSS method from the others is that NDSS makes analysis using the time dependent deformation properties of rock mass and engineering judgement. During the evaluation process, NDSS gives the permission of questioning the field observations, measurements and timedependent support performance. These transactions are carried out with 3-dimensional numeric modeling analysis. The goal of NDSS is to design a support system which does not allow greater deformation of the support system than that calculated by numerical modeling. In this paper, NDSS applied to the problems of Tunnel 34 of the same Project (excavated with NATM method, has a length of 2218 meters), which is driven in graphite schist, was illustrated. Results of the system analysis and insitu measurements successfully coincide with each other.
2
Effects of Dietary Lycopene and Vitamin E on Egg Production, Antioxidant Status and Cholesterol Levels in Japanese Quail

N. Sahin,K. Sahin,M. Onderci,M. Karatepe,M. O. Smith,O. Kucuk 아세아·태평양축산학회 2006 Animal Bioscience Vol.19 No.2
- 원문보기 2
  ScienceON
  
  KCI
Japanese Quails were used to evaluate the effects of dietary supplementation with vitamin E (dl-a-tocopheryl-acetate), lycopene, and their combination on egg production, egg quality, concentrations of malondialdehyde (MDA), vitamin E, A and cholesterol in serum and egg yolk. Quails (n = 120; 55 d old) were divided into four groups (n = 30/group) and fed a basal diet or the basal diet supplemented with lycopene (100 mg/kg diet), vitamin E (250 mg dl-慣-tocopheryl-acetate/kg diet) or a combination of lycopene and vitamin E (100 mg/kg lycopene plus 250 mg dl-慣-tocopheryl-acetate/kg diet). Vitamin E and lycopene did not affect (p>0.05) body weight, feed intake or egg weight. Egg production and Haugh unit were greater (p<0.05) in each supplemental group compared with the control group (p<0.05). Serum and liver MDA levels were decreased in supplemented groups compared with the control group. Separately or as a combination, supplemental lycopene and vitamin E increased serum and egg yolk vitamin E and A but decreased cholesterol concentrations (p<0.05). In general, when a significant effect was found for a parameter, the magnitude of the responses to vitamin and lycopene supplements was greatest with the combination of the lycopene and vitamin E, rather than that observed with each supplement separately. Results of the present study indicate that supplementing with a combination of dietary lycopene and vitamin E reduced serum and yolk cholesterol concentrations and improved antioxidant status.
3
Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

Amin, A.R.M.R.,Karpowicz, P.A.,Carey, T.E.,Arbiser, J.,Nahta, R.,Chen, Z.G.,Dong, J.T.,Kucuk, O.,Khan, G.N.,Huang, G.S.,Mi, S.,Lee, H.Y.,Reichrath, J.,Honoki, K.,Georgakilas, A.G.,Amedei, A.,Amin, A. Saunders Scientific Publications ; Academic Press 2015 SEMINARS IN CANCER BIOLOGY Vol.35 No.suppl
- 원문보기
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Kruppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting.