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Comparison of IOL powers by corrected method in eyes after PRK and LASIK
O Sub Koo,June Gone Kim,Byung Joo Song 대한안과학회 2002 Korean Journal of Ophthalmology Vol.16 No.1
The purpose of this study is to compare, by statistical analysis, intraocular lens (IOL) powers by SRK/T formula using autorefractokeratometer-measured keratometric (K) values (SRK/T-ARK-mK), by SRK/T formula using refraction-derived K values (SRK/T-R-dK), and by refraction corrected method (RCM), in eyes treated with photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for myopia. Thirty-eight consecutive eyes of 23 patients with PRK for mild to moderate myopia and 35 consecutive eyes of 25 patients with LASIK for high myopia were followed up for more than 1 year. In the two groups, IOL powers by SRK/T-ARK-mK, by SRK/T-R-dK, and by RCM were compared by statistical analysis. In PRK group, the mean value of IOL powers by RCM was statistically higher than that obtained by the other two methods (p <; 0.05), while there was no significant statistical difference between the mean values of IOL powers by SRK/T-ARK-mK and by SRK/T-R-dK (p > 0.05). However, in LASIK group, the mean values of IOL powers by RCM and by SRK/T-R-dK, which did not differ statistically (p > 0.05), were both statistically higher than that by SRK/T-ARK-mK (p < 0.05). In conclusion, there is a statistical difference in IOL powers by the methods used for IOL calculation, as there is according to the level of myopia in patients with PRK and LASIK treatment. We suggest that, in IOL power calculation in eyes with previous corneal refractive surgery, correction methods such as RCM and SRK/T-R-dK are more effective at higher levels of myopia.
섬유주 각막 이행부위의 형태학적 특성: 편평조직표본 및 미세구조
구오섭,고명규,O Sub Koo,Myung Kyoo Ko 대한안과학회 2007 대한안과학회지 Vol.48 No.5
Purpose: To evaluate the morphological characteristics of the transitional zone between the corneal endothelium and the trabecular meshwork by flat preparation and electron microscopy. Methods: The materials comprised 12 eyes examined by the flat preparation and 7 eyes by the electron microscopy. The specimens were derived from the transitional tissue between the corneal endothelium and the trabecular meshwork. The specimens in the flat preparation were stained with hematoxylin-eosin and examined by light microscopy. The specimens for scanning electronic microscopy (SEM) and in transmission electronic microscopy (TEM) were examined through routine processes. Results: In the specimens examined by the flat preparation, unlike peripheral corneal endothelial cells, the endothelial cell nuclei in the transitional zone were overlapped and morphologically oval. On SEM, unlike typical hexagonality and tight interdigitation of corneal endothelial cells, the endothelial cells in the transitional zone were partially successive, spaced intercellularly, and morphologically irregular. On TEM, the endothelial cells in the transitional zone were partially successive. Conclusions: The loss of cell-cell contact of endothelial cells in the transitional zone may lead to the potential proliferation capacity of endothelial cells in the transitional zone under specific conditions. Therefore, further studies on the proliferation capacity of endothelial cells in the transitional zone are needed together with more research on cell biology.
조희준,구오섭,Hee-Jun Cho,O-Sub Koo 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To determine the Orbscan corneal power which gave the best correlation with refraction-derived keratometric value (clinical history method) after LASIK in cataract surgery. Methods: A total of 38 consecutive eyes of 19 patients who were followed up for at least 1 year after LASIK were included in study. The refraction-derived keratometric values were correlated with Orbscan corneal power within 1, 2, 3, 4, and 5 mm diameter zones of keratometric, anterior and total selections of mean, axial, tangential and optical power maps. Results: The Orbscan corneal power of the 5-mm zone optical power total map gave the best correlation with refraction-derived keratometric value. The following regular relationship in linear regression analysis was derived: RDKV(refraction-derived keratometric value)=0.9×OPT5(corneal power of Orbscan optical power total map 5-mm zone)+4.941(r=0.883). Conclusions: These results indicate that the corneal power of the 5-mm zone optical power total map was the most appropriate to calculate IOL power in cataract surgery after LASIK when using Orbscan topography.
중등도 근시환자의 엑시머레이저각막절제술 후 술 전 자료가 없는 경우 인공수정체 도수계산
조희준,오청훈,구오섭,Hee-Jun Cho,Chung-Hoon Oh,O-Sub Koo 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To evaluate the correlation between the conventional method and the clinical history method for intraocular lens power calculation for cataract surgery in eyes with previous photorefractive keratectomy in the absence of pre-PRK data. Methods: The medical records of 38 eyes in 23 patients who had been treated with PRK for myopia and were followed up for more than 1 year were reviewed. The IOL powers by conventional method using post-PRK keratometric value and by clinical history method were compared. Results: The mean values of IOL powers by conventional method, and by clinical history method were +20.58±1.10D (range, +16.37~+22.80D) and +21.06±0.85D (range, +18.85~+22.8D), respectively. The following equation describes the regular relationship between the two methods: IOLCHM (clinical history method)= 0.683*IOLCM (conventional method) +7.005 (r=0.878, p<.01). When the IOL powers by conventional method were applied to this equation, the mean difference of value between the IOL powers calculated from this equation and those of the clinical history method was?0.01±0.41D (range, -0.99~+0.76D). Conclusions: This equation will be helpful to calculate the IOL power for cataract surgery in eyes with previous PRK in the absence of pre-PRK data.
( Seong Hwan Wang ),( Eun Bum Kang ),( In Su Kwon ),( Jung Hoon Koo ),( Kwang O Shin ),( Yong Chul Jang ),( Hyun Sub Um ),( Yoo Sung Oh ),( Chul Hyun Kim ),( In Ho Cho ),( Joon Yong Cho ) 한국운동영양학회 2012 Physical Activity and Nutrition (Phys Act Nutr) Vol.16 No.2
Alzheimer`s disease (AD) is the most common cause of dementia in adults. Microtubule associated protein tau is abnormally phosphorylated in AD and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). NFTs are the most common intraneuronal inclusion in the brains of patients with AD and have been implicated in mediating neuronal cell death and cognitive deficit. Aberrant phosphorylation of tau is an early pathological event in AD, but the underlying mechanisms are unclear. MAP kinases are a family of Serine/Threonine (Ser/Thr) kinases that involved hyper - phosphorylation of tau in AD. The purpose of this study was to investigate the effect of treadmill exercise on phosphorylation of tau level and activation of MAPKs including JNK, ERK, p38-MAPK, To address this, Tg mouse model of AD, Tg-NSE/hTau 23, which expresses human tau 23 in the brain, was chosen. Animals were subjected to treadmill exercise for 12 weeks from 24 months of age, Treadmill exercise in Tg group improved cognitive function compared with Tg-SED group in watermaze test. In addition, treadmill exercised Tg mice significantly reduced the activation of JNK54/46, p38-MAPK and tau (Ser404, Ser202, Thr231), and increased activation of ERK44/42 in cerebral cortex. These results suggest that treadmill exercise may provide a therapeutic potential to alleviate the tau pathology like AD.