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Implications of 3-Dimensional Printed Spinal Implants on the Outcomes in Spine Surgery
Fiani, Brian,Newhouse, Alexander,Cathel, Alessandra,Sarhadi, Kasra,Soula, Marisol The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.4
Three-dimensional printing (3DP) applications possess substantial versatility within surgical applications, such as complex reconstructive surgeries and for the use of surgical resection guides. The capability of constructing an implant from a series of radiographic images to provide personalized anatomical fit is what makes 3D printed implants most appealing to surgeons. Our objective is to describe the process of integration of 3DP implants into the operating room for spinal surgery, summarize the outcomes of using 3DP implants in spinal surgery, and discuss the limitations and safety concerns during pre-operative consideration. 3DP allows for customized, light weight, and geometrically complex functional implants in spinal surgery in cases of decompression, tumor, and fusion. However, there are limitations such as the cost of the technology which is prohibitive to many hospitals. The novelty of this approach implies that the quantity of longitudinal studies is limited and our understanding of how the human body responds long term to these implants is still unclear. Although it has given surgeons the ability to improve outcomes, surgical strategies, and patient recovery, there is a need for prospective studies to follow the safety and efficacy of the usage of 3D printed implants in spine surgery.
Zhang, Lingzhi,Lyons, Leslie,Newhouse, Jocelyn,Zhang, Zhengcheng,Straughan, Megan,Chen, Zonghai,Amine, Khalil,Hamers, Robert J.,West, Robert Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.38
<P>Alkylsilane ethers, containing one or three carbon spacer groups between the silicon atom and oligo(ethylene oxide) moiety, were designed and synthesized. These compounds are non-hydrolyzable and less flammable than their alkoxysilane counterparts. A full cell test using them as electrolyte solvents showed good cycling performance in lithium-ion batteries.</P> <P>Graphic Abstract</P><P>Alkylsilane ethers with oligo(ethylene oxide) substituents were designed and synthesized as safe electrolyte solvents which showed good cycling performance doped with LiBOB in lithium-ion cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm01596b'> </P>
Georges Jabbour,Lise Belliveau,David Probizanski,Ian Newhouse,Jim McAuliffe,Jennifer Jakobi,Michel Johnson 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.3
The purpose of this study was to examine the effect of low-frequency neuromuscular electrical stimulation (NMES) on glucose profile in persons with type 2 diabetes mellitus (T2DM). Eight persons with T2DM (41 to 65 years) completed a glucose tolerance test with and without NMES delivered to the knee extensors for a 1-hour period at 8 Hz. Three blood samples were collected: at rest, and then 60 and 120 minutes after consumption of a glucose load on the NMES and control days. In NMES groups glucose concentrations were significantly lower (P<0.01) than in the control conditions. Moreover, a significant positive correlation (r=0.9, P<0.01) was obtained between the intensity of stimulation and changes in blood glucose. Our results suggest that low-frequency stimulation seem suitable to induce enhance glucose uptake in persons with T2DM. Moreover, the intensity of stimulation reflecting the motor contraction should be considered during NMES procedure.
CADASIL as a Useful Medical Model and Genetic Form of Vascular Depression
Park, Joon Hyuk,Jeon, Bong-Hee,Lee, Jung Seok,Newhouse, Paul A.,Taylor, Warren D.,Boyd, Brian D.,Kim, Ki Woong,Kim, Moon-Doo Lippincott Williams & Wilkins 2017 American Journal of Geriatric Psychiatry Vol. No.
<P>Objective: The main magnetic resonance imaging (MRI) findings of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are white matter hyperintensities (WMHs), lacunar infarctions, and cerebral microbleeds (CMBs). The purpose of this study was to investigate the effects of these three neuroimaging markers of CADASIL on depression to determine whether CADASIL is a useful medical model supporting the vascular depression hypothesis. Methods: Eighty-four subjects with CADASIL, aged 34-86 years, participated in this study. They underwent comprehensive clinical evaluation, including 3T MRI and genotyping of NOTCH3. The effects of WMH, lacunar infarctions, and CMBs were analyzed by path analyses and multivariate logistic regression analyses. Results: Patients with CADASIL exhibited frequencies of 17.9% for major depressive disorder (MDD) and 10.7% for minor depressive disorder. The frequency of MDD increased from 5.0% to 46.2% asWMH volume increased from first quartile to fourth quartile. WMH volume (OR: 1.03, 95% CI: 1.003-1.06) in patients with CADASIL was associated with the current depressive disorder. Path analyses demonstrated that only WMH volume was associated with the Korean version of the short form Geriatric Depression Scale score, Center for Epidemiologic Studies Depression Scale score, and 17-item Hamilton depression scale score. The effects of lacunar infarctions and CMBs on depression were not significant in path analyses and multivariate logistic regression analyses. Conclusions: This study demonstrates that WMHs are closely associated with depression in patients with CADASIL. This supports that CADASIL might be a useful medical model and genetic form of vascular depression.</P>
Dennis Danforth,Rodney A. Gabriel,Anthony I. Clark,Beverly Newhouse,Swapnil Khoche,Sanjana Vig,Ramon Sanchez,Ulrich H. Schmidt 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.1
Background: Despite improvements in techniques and management of liver transplant patients, numerous perioperative complications that contribute to perioperative mortality remain. Models to predict intraoperative massive blood transfusion, prolonged mechanical ventilation, or in-hospital mortality in liver transplant recipients have not been identified. In this study we aim to identify preoperative factors associated with the above mentioned complications. Methods: A retrospective observational analysis was conducted on data collected from 124 orthotopic liver transplants performed at a single institution between 2014 and 2017. A multivariable logistic regression using backwards elimination was performed for three defined outcomes (massive transfusion ≥ 10 units packed red blood cells (PRBC), prolonged mechanical ventilation > 24 h, and in-hospital mortality) to identify associations with preoperative characteristics. Results: Statistically significant (P < 0.05) associations with massive transfusion ≥ 10 units PRBC were hepatocellular carcinoma and preoperative transfusion of PRBC. Significant associations with prolonged mechanical ventilation > 24 h were hepatitis C, alcoholic hepatitis, elevated preoperative alanine aminotransferase, and hepatorenal syndrome. Male gender was protective for requiring prolonged mechanical ventilation. End-stage renal disease and hepatitis B were significantly associated with increased in-hospital mortality. Conclusions: This study identified risk factors associated with common perioperative complications of liver transplantation. These factors may assist practitioners in risk stratification and may form the basis for further investigations of potential interventions to mitigate these risks.