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Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells
( Cai Hong Zhou ),( Qi Shen ),( Jin Glun Xue ),( Chao Neng Ji ),( Jin Zhong Chen ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.2
TTRAP is a multi-functional protein that is involved in multiple aspects of cellular functions including cell proliferation, apoptosis and the repair of DNA damage. Here, we demonstrated that the lentivirus-mediated overexpression of TTRAP significantly inhibited cell growth and induced apoptosis in osteosarcoma cells. The ectopic TTRAP suppressed the growth and colony formation capacity of two osteosarcoma cell lines, U2OS and Saos-2. Cell apoptosis was induced in U2OS cells and the cell cycle was arrested at G2/M phase in Saos-2 cells. Exogenous expression of TTRAP in serum-starved U2OS and Saos-2 cells induced an increase in caspase-3/-7 activity and a decrease in cyclin B1 expression. In comparison with wild-type TTRAP, mutations in the 5`-tyrosyl-DNA phosphodiesterase activity of TTRAP, in particular TTRAPE152A, showed decreased inhibitory activity on cell growth. These results may aid in clarifying the physiological functions of TTRAP, especially its roles in the regulation of cell growth and tumorigenesis. [BMB Reports 2013; 46(2): 113-118].
Wen-Jie Zou,Chin-Wei Huang,Yung-Ho Chiu,Neng Shen,Shu-Mei Wang 기술경영경제학회 2016 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.24 No.3
This study uses the dynamic data envelopment analysis (DEA) model to evaluate intertemporalefficiency for high-tech industries in China. The significant difference from previous studies isthe assumption for patents, which are defined to be a carry-over intermediate linking differentterms. The model further provides an indicator of adjustment ratio for patents, based on theassessment of optimal quantity of patents. Output and input inefficiency indicators are alsodeveloped in the model to explore the sources of operational inefficiency. The empiricalresults conclude that intertemporal efficiency trends upward over time; the quantity ofpatents is assessed to be in shortage during the early terms, but excessive in recent terms;and that deficits in financial output is a significant factor in creating inefficiency.