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Monoamine Oxidase Inhibitory Flavonoids from the Root Bark of Cudrania tricuspidata
Xiang Hua Han,Ji Hye Hwang,홍성수,Sanggil Choe,Chul Lee,이문순,이동호,Myung Koo Lee1,2,,이미경 한국생약학회 2010 Natural Product Sciences Vol.16 No.2
Two new benzylated flavonoids, 5,7,4'-trihydroxy-6-p-hydroxybenzylflavanone (1) and 5,7,4'-trihydroxy-6,8-di-p-hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 mM, respectively.