The influence of root surface distance to alveolar bone and periodontal ligament on periodontal wound healing

Montevecchi, Marco,Parrilli, Annapaola,Fini, Milena,Gatto, Maria Rosaria,Muttini, Aurelio,Checchi, Luigi Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.5

Purpose: The purpose of this animal study was to perform a 3-dimensional micro-computed tomography (micro-CT) analysis in order to investigate the influence of root surface distance to the alveolar bone and the periodontal ligament on periodontal wound healing after a guided tissue regeneration (GTR) procedure. Methods: Three adult Sus scrofa domesticus specimens were used. The study sample included 6 teeth, corresponding to 2 third mandibular incisors from each animal. After coronectomy, a circumferential bone defect was created in each tooth by means of calibrated piezoelectric inserts. The experimental defects had depths of 3 mm, 5 mm, 7 mm, 9 mm, and 11 mm, with a constant width of 2 mm. One tooth with no defect was used as a control. The defects were covered with a bioresorbable membrane and protected with a flap. After 6 months, the animals were euthanised and tissue blocks were harvested and preserved for micro-CT analysis. Results: New alveolar bone was consistently present in all experimental defects. Signs of root resorption were observed in all samples, with the extent of resorption directly correlated to the vertical extent of the defect; the medial third of the root was the most commonly affected area. Signs of ankylosis were recorded in the defects that were 3 mm and 7 mm in depth. Density and other indicators of bone quality decreased with increasing defect depth. Conclusions: After a GTR procedure, the periodontal ligament and the alveolar bone appeared to compete in periodontal wound healing. Moreover, the observed decrease in bone quality indicators suggests that intrabony defects beyond a critical size cannot be regenerated. This finding may be relevant for the clinical application of periodontal regeneration, since it implies that GTR has a dimensional limit.

Subgingival pathogens in chronic periodontitis patients affected by type 2 diabetes mellitus: a retrospective case-control study

Montevecchi, Marco,Valeriani, Leoluca,Gatto, Maria Rosaria,D'Alessandro, Giovanni,Piana, Gabriela Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.-

Purpose: The aim of this study was to compare the prevalence and bacterial load of 6 main periodontal pathogens between pairs of periodontal patients with and without type 2 diabetes mellitus. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans genotypes were also investigated. Methods: Twenty patients affected by chronic periodontitis and type 2 diabetes were retrospectively selected and matched to 20 patients without diabetes on the basis of the degree and severity of periodontal disease. Microbiological data of subgingival biofilms were analysed and compared for the examined pathogens: A. actinomycetemcomitans, P. gingivalis, Prevotella intermedia, Treponema denticola, Fusobacterium nucleatum, and Tannerella forsythia. Results: The pairs were balanced in terms of demographic and clinical parameters, except for bleeding on probing and suppuration. In the microbiological test sites (4 for each patient), the mean probing pocket depth was 6.34±1.63 mm in patients with diabetes and 6.41±1.78 mm in patients without diabetes. No significant difference between pairs in the prevalence of P. gingivalis or the distribution of its genotypes was recorded. Patients with diabetes had a significantly greater amount of total bacterial load, P. gingivalis, T. denticola, T. forsythia, and F. nucleatum (P<0.05). Moreover, patients with diabetes had a higher number of sites with a greater cell count than patients without diabetes. When compared to the total bacterial load, only T. forsythia maintained its relative load in patients with diabetes (P=0.001). Conclusions: This retrospective matched study supports the hypothesis that microbiological differences exist among periodontal patients with and without diabetes mellitus.

Subgingival pathogens in chronic periodontitis patients affected by type 2 diabetes mellitus: a retrospective case-control study

Marco Montevecchi,Leoluca Valeriani,Maria Rosaria Gatto,Giovanni D'Alessandro,Gabriela Piana 대한치주과학회 2021 Journal of Periodontal & Implant Science Vol.51 No.6

Purpose: The aim of this study was to compare the prevalence and bacterial load of 6 main periodontal pathogens between pairs of periodontal patients with and without type 2 diabetes mellitus. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans genotypes were also investigated. Methods: Twenty patients affected by chronic periodontitis and type 2 diabetes were retrospectively selected and matched to 20 patients without diabetes on the basis of the degree and severity of periodontal disease. Microbiological data of subgingival biofilms were analysed and compared for the examined pathogens: A. actinomycetemcomitans, P. gingivalis, Prevotella intermedia, Treponema denticola, Fusobacterium nucleatum, and Tannerella forsythia. Results: The pairs were balanced in terms of demographic and clinical parameters, except for bleeding on probing and suppuration. In the microbiological test sites (4 for each patient), the mean probing pocket depth was 6.34±1.63 mm in patients with diabetes and 6.41±1.78 mm in patients without diabetes. No significant difference between pairs in the prevalence of P. gingivalis or the distribution of its genotypes was recorded. Patients with diabetes had a significantly greater amount of total bacterial load, P. gingivalis, T. denticola, T. forsythia, and F. nucleatum (P<0.05). Moreover, patients with diabetes had a higher number of sites with a greater cell count than patients without diabetes. When compared to the total bacterial load, only T. forsythia maintained its relative load in patients with diabetes (P=0.001). Conclusions: This retrospective matched study supports the hypothesis that microbiological differences exist among periodontal patients with and without diabetes mellitus. Trial Registration: ClinicalTrials.gov Identifier: NCT03786133

The influence of root surface distance to alveolar bone and periodontal ligament on periodontal wound healing

Marco Montevecchi,Annapaola Parrilli,Milena Fini,Maria Rosaria Gatto,Aurelio Muttini,Luigi Checchi 대한치주과학회 2016 Journal of Periodontal & Implant Science Vol.46 No.5

Purpose: The purpose of this animal study was to perform a 3-dimensional micro-computed tomography (micro-CT) analysis in order to investigate the influence of root surface distance to the alveolar bone and the periodontal ligament on periodontal wound healing after a guided tissue regeneration (GTR) procedure. Methods: Three adult Sus scrofa domesticus specimens were used. The study sample included 6 teeth, corresponding to 2 third mandibular incisors from each animal. After coronectomy, a circumferential bone defect was created in each tooth by means of calibrated piezoelectric inserts. The experimental defects had depths of 3 mm, 5 mm, 7 mm, 9 mm, and 11 mm, with a constant width of 2 mm. One tooth with no defect was used as a control. The defects were covered with a bioresorbable membrane and protected with a flap. After 6 months, the animals were euthanised and tissue blocks were harvested and preserved for micro-CT analysis. Results: New alveolar bone was consistently present in all experimental defects. Signs of root resorption were observed in all samples, with the extent of resorption directly correlated to the vertical extent of the defect; the medial third of the root was the most commonly affected area. Signs of ankylosis were recorded in the defects that were 3 mm and 7 mm in depth. Density and other indicators of bone quality decreased with increasing defect depth. Conclusions: After a GTR procedure, the periodontal ligament and the alveolar bone appeared to compete in periodontal wound healing. Moreover, the observed decrease in bone quality indicators suggests that intrabony defects beyond a critical size cannot be regenerated. This finding may be relevant for the clinical application of periodontal regeneration, since it implies that GTR has a dimensional limit.

Language,Education ; Culture in Language: comparing cultures through words in South Africa

( Michela Montevecchi ) 경희대학교 글로벌인문학술원 2011 비교문화연구 Vol.24 No.-

South Africa is a multiracial country where different cultures and languages coexist. Culture can be conveyed through language. Language conditioning is also social conditioning, and through words we make sense of our own and others` experience. In this paper I investigate the meaning of two culturally significant words: (English) peace and (African) ubuntu. Data findings will show how L2 speakers of English, when asked to define peace, promptly operate a process of transfer of the meaning from their mother-tongue Xhosa equivalent - uxolo - to its English equivalent. Ubuntu, an African word which encompasses traditional African values, has no counterpart in English. I will also argue how, in the ongoing process of globalisation, English is playing a predominant role in promoting cultural homogenization.

Integrated WAAM-Subtractive versus Pure Subtractive Manufacturing Approaches: an Energy Efficiency Comparison

Gianni Campatelli,Filippo Montevecchi,Giuseppe Venturini,Giuseppe Ingarao,Paolo C. Priarone 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.1

Over the last years, additive manufacturing (AM) has been gathering momentum both in the academic and in the industrial world. Besides the obvious benefits in terms of flexibility and process capabilities, the environmental performance of such processes has still to be properly analyzed. Actually, the advantages of additive manufacturing over conventional processes are not obvious. Indeed, different manufacturing approaches result in different amounts of involved material and in different processing energy demands. Environmental comparative analyses are hence crucial to properly characterize AM processes. In this paper, an energetic comparison between the emerging wire arc additive manufacturing (WAAM) process and a traditional machining-from-bulk solution to produce a steel blade is presented. A methodology accounting for all the material and energy flows of the whole component life cycle is proposed. Experimental measurements and environmental databases are used to quantify the primary energy demand at each stage of the life cycle. The results reveal that, for the analyzed case study, an integrated additive (WAAM)-subtractive manufacturing route enables significant material and primary energy savings with respect to traditionally applied approaches.