Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis

Liang, Hong-Jie,Yan, Yu-Lan,Liu, Zhi-Ming,Chen, Xu,Peng, Qi-Liu,Wang, Jian,Mo, Cui-Ju,Sui, Jing-Zhe,Wu, Jun-Rong,Zhai, Li-Min,Yang, Shi,Li, Tai-Jie,Li, Ruo-Lin,Li, Shan,Qin, Xue Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and gliomas remains inclusive or controversial. For better understanding of the effect of XRCC3 Thr241Met polymorphism on glioma risk, a meta-analysis was performed. All eligible studies were identified through a search of PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase) and Chinese Biomedical Literature Database (CBM) before May 2013. The association between the XRCC3 Thr241Met polymorphism and gliomas risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of nine case-control studies including 3,533 cases and 4,696 controls were eventually collected. Overall, we found that XRCC3 Thr241Met polymorphism was significantly associated with the risk of gliomas (T vs. C: OR=1.10, 95%CI=1.01-1.20, P=0.034; TT vs. CC: OR=1.30, 95%CI=1.03-1.65, P=0.027; TT vs. TC/CC: OR=1.29, 95%CI=1.01-1.64, P=0.039). In the subgroup analysis based on ethnicity, the significant association was found in Asian under four models (T vs. C: OR=1.17, 95%CI=1.07-1.28, P=0.00; TT vs. CC: OR=1.79, 95%CI=1.36-2.36, P=0.00; TT vs. TC/CC: OR=1.75, 95%CI=1.32-2.32, P=0.00; TT/TC vs. CC: OR=1.11,95% CI=1.02-1.20). This meta-analysis suggested that the XRCC3 Thr241Met polymorphism is a risk factor for gliomas, especially for Asians. Considering the limited sample size and ethnicities included in the meta-analysis, further large scale and well-designed studies are needed to confirm our results.

Single‑wire power transfer method and verification

Yang Li,Yu-jie Zhai,Yao Li,Xue-liang Wang,Tao-cheng Hu 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.4

As a novel power supply method, single-wire power transfer has gained a great deal of attention. However, most of the related studies were based on using loops to realize a two-way power transfer. To further develop single-wire power transfer technology, a single-wire power transfer method is proposed in this paper, which does not rely on loops for power transfer. Through theoretical derivation, its transfer principle is analyzed, and a single-wire power transfer structure is designed. In addition, the theoretical derivation is verified by simulation analysis. Finally, the factors and laws that affect transfer efficiency are obtained through simulations and experiments. The research conducted in this paper is conducive to the development of single-wire power transfer methods, and lays a foundation for further research on transfer characteristics.

Prediction of operating reliability of multi-body mechanism in micro-switches considering parameter distribution and wear of parts

Donghui Li,Xue Zhou,Sanqiang Ling,Yue Jin,Guofu Zhai 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7

Traditional method evaluates operating reliability by counting life-test results of a small number of samples, which ignores variability between individuals and cannot accurately reflect the true state. This paper proposes a model for predicting operational reliability of mechanism in a batch of micro-switches based on manufacturing parameters, in view of complex structure and diverse manufacturing parameters. A multi-body kinetic model based on manufacturing parameters and principle of action considering contact fatigue and wear was established, and the operating characteristics in the degradation process with sliding wear of joints were obtained. Finally, the linkage with revolute clearance in miniature circuit breaker (MCB) was used as numerical example application to perform investigation. Prediction results are consistent with batch experiments, which verifies accuracy of model. In addition, the optimal combination of clearances was obtained by using genetic algorithm based on predicted model, which increases locking reliability to 99.3 % after 10000 operation cycles.

A simulated experimental system and risk prediction method for ignition caused by overhead lines short-circuit

Donghui Li,Yuguang Zhong,Xue Zhou,Guofu Zhai 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12

In windy weather, overhead lines swing and collide with each other, often resulting in short-circuits and arc faults. The line is partially molten and produces numerous hot metal particles, which fall and may ignite the fuels on the ground. This paper developed an experimental system to obtain hot particle dimensions at different short-circuit current levels. Based on the results of this experiment, an ignition prediction method was developed. The particle parameters from the experiments were used as a bridge that to complete the prediction from short-circuit current to ignition risk. A neural network was trained according to the experimental and calculated results, then used to predict the risk of ignition. The overhead lines in a forest were used as an example application to perform thte investigation. The results show that copper lines in a forest with needles on the ground create a high risk of ignition hazard.

The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx

Hai-Xia Li,Yan Ma,Yu-Xiao Yan,Xin-Ke Zhai,Meng-Yu Xin,Tian Wang,Dong-Cao Xu,Yu-Tong Song,Chun-Dong Song,Cheng-Xue Pan 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6

Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important rolein store-operated Ca2þ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protectionagainst myocardial ischemia (MI) injury. SOCE, comprising STIM1, ORAI1 and TRPC1, contributesto intracellular Ca2þ ([Ca2þ]i) accumulation in cardiomyocytes. The purified extract of steamed Panaxginseng (EPG) attenuated [Ca2þ]i overload against MI injury. Thus, the aim of this study was to investigatethe possibility of EPG affecting p-caveolin-1 to further mediate SOCE/[Ca2þ]i against MI injury in neonatalrat cardiomyocytes and a rat model. Methods: PP2, an inhibitor of p-caveolin-1, was used. Cell viability, [Ca2þ]i concentration were analyzedin cardiomyocytes. In rats, myocardial infarct size, pathological damages, apoptosis and cardiac fibrosiswere evaluated, p-caveolin-1 and STIM1 were detected by immunofluorescence, and the levels ofcaveolin-1, STIM1, ORAI1 and TRPC1 were determined by RT-PCR and Western blot. And, release of LDH,cTnI and BNP was measured. Results: EPG, ginsenosides accounting for 57.96%, suppressed release of LDH, cTnI and BNP, and protectedcardiomyocytes by inhibiting Ca2þ influx. And, EPG significantly relieved myocardial infarct size, cardiacapoptosis, fibrosis, and ultrastructure abnormality. Moreover, EPG negatively regulated SOCE viaincreasing p-caveolin-1 protein, decreasing ORAI1 mRNA and protein levels of ORAI1, TRPC1 and STIM1. More importantly, inhibition of the p-caveolin-1 significantly suppressed all of the above cardioprotectionof EPG. Conclusions: Caveolin-1 phosphorylation is involved in the protective effects of EPG against MI injury viaincreasing p-caveolin-1 to negatively regulate SOCE/[Ca2þ]i.

Spin conductance in three-terminal rings subject to Rashba and Dresselhaus spin-orbit coupling

Han-Zhao Tang,Li-Xue Zhai,Jian-Jun Liu 한국물리학회 2018 Current Applied Physics Vol.18 No.1

Based on the Green's function formalism, we investigated spin transport properties in one-dimensional three-terminal rings in the presence of the Rashba spin-orbit coupling (RSOC) and Dresselhaus spin-orbit coupling (DSOC). The conductance as a function of the Fermi energy shows typical resonance and antiresonance (conductance zero) characteristics in the absence of spin-orbit coupling (SOC). When one type of SOC (RSOC or DSOC) is introduced, the original conductance zeros are lifted, but new conductance zeros emerge. It is found that all the conductance zeros depend sensitively on the disorder, and the fluctuate weakens and smoothens the oscillations of the conductance. In the presence of both types of SOCs, the interplay between the RSOC and the DSOC opens a gap in the energy spectrum and breaks the cylindrical symmetry of the ring. Consequently, symmetrically coupled three-terminal rings show anisotropic conductances, which are robust against weak disorders.