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Hydraulic Optimization of Multiphase Pump Based on CFD and Genetic Algorithm
Hu Hao,Li Xinkai,Gu Bo 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.6
Impellers of helicon-axial multiphase pump are optimized based on CFD and genetic algorithm. The method mainly includes: CFD numerical calculation, to establish nonlinear relation through neural network, and genetic algorithm optimization extreme. Firstly, the profile of blades is parametric by spline surface and Choose 12 control points as optimization variables. Then, every optimization variable is given optimal dimension. Finally, sample database is got by using standard L27_3_13 orthogonal design table. Next, output values are got by modeling every sample, meshing generation and using CFD numerical calculation. Train neural networks through the database; thus the nonlinear relation between the blade parameter and pump performance parameters is built by applying the nonlinear fitting ability of BP neural networks. Regard the trained neural network as a fitness function of the genetic algorithm and use the characteristic of nonlinear global optimization of genetic algorithm to optimize the multiphase pump. Optimization result shows that the hydraulic efficiency of the multiphase pump is increased by 1.91%.
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Tao Liang,Xuxiao Ye,Yuanyuan Liu,Xinkai Qiu,Zuowei Li,Binqiang Tian,Dongliang Yan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
FAM46B is a member of the family with sequence similarity 46. Little is known about the expression and functional role (s) of FAM46B in prostate cancer (PC). In this study, the expression of FAM46B expression in The Cancer Genome Atlas, GSE55945, and an independent hospital database was measured by bioinformatics and real-time PCR analysis. After PC cells were transfected with siRNA or a recombinant vector in the absence or presence of a β-catenin signaling inhibitor (XAV-939), the expression levels of FAM46B, C-myc, Cyclin D1, and β-catenin were measured by western blot and realtime PCR. Cell cycle progression and cell proliferation were measured by flow cytometry and the CCK-8 assay. The effects of FAM46B on tumor growth and protein expression in nude mice with PC tumor xenografts were also measured. Our results showed that FAM46B was downregulated but that β-catenin was upregulated in patients with PC. FAM46B silencing promoted cell proliferation and cell cycle progression in PC, which were abrogated by XAV-939. Moreover, FAM46B overexpression inhibited PC cell cycle progression and cell proliferation in vitro and tumor growth in vivo. FAM46B silencing promoted β-catenin protein expression through the inhibition of β-catenin ubiquitination. Our data clearly show that FAM46B inhibits cell proliferation and cell cycle progression in PC through ubiquitination of β-catenin.
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