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Lee, Su-Un,Hong, Jong Wook,Choi, Sang-Il,Han, Sang Woo American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.14
<P>We report a universal sulfide-assisted synthesis strategy to prepare dumbbell-like M–Ag heterodimers (M = Pd, Au, Pt). Sulfide ions can give fine control over the reaction kinetics of Ag precursors, resulting in the anisotropic overgrowth of Ag to realize the dumbbell-like heterodimers irrespective of the surface facets or components of the M domain. The M–Ag heterodimers were facilely transformed to M–Ag<SUB>2</SUB>S heterodimers via a simple sulfidation reaction. This study provides a versatile approach to realizing not only metal–metal heterodimers but also semiconductor–metal heterodimers and will pave the way for designing heteronanostructures with unprecedented morphologies and functions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-14/ja500552p/production/images/medium/ja-2014-00552p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja500552p'>ACS Electronic Supporting Info</A></P>
Oceanimonas marisflavi sp. nov., a polycyclic aromatic hydrocarbon-degrading marine bacterium
Lee, Dong Wan,Lee, Hanbyul,Kwon, Bong-Oh,Khim, Jong Seong,Yim, Un Hyuk,Park, Hongjae,Park, Byeonghyeok,Choi, In-Geol,Kim, Beom Seok,Kim, Jae-Jin Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.9
Nitric Oxide in the Kidney: Its Physiological Role and Pathophysiological Implications
( Jong Un Lee ) 대한전해질학회 2008 Electrolytes & Blood Pressure Vol.6 No.1
Nitric oxide has been implicated in many physiologic processes that influence both acute and long-term control of kidney function. Its net effect in the kidney is to promote natriuresis and diuresis, contributing to adaptation to variations of dietary salt intake and maintenance of normal blood pressure. A pretreatment with nitric oxide donors or L-arginine may prevent the ischemic acute renal injury. In chronic kidney diseases, the systolic blood pressure is correlated with the plasma level of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase. A reduced production and biological action of nitric oxide is associated with an elevation of arterial pressure, and conversely, an exaggerated activity may represent a compensatory mechanism to mitigate the hypertension.
A novel frameshift mutation in the EYA1 gene in a Korean family with Branchio-oto-renal syndrome.
Lee, Jong Dae,Kim, Shi-Chan,Koh, Yoon Woo,Lee, Hye-Jin,Choi, Soo-Young,Kim, Un-Kyung Institute for Clinical Science] 2009 Annals of clinical and laboratory science Vol.39 No.3
<P>Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by branchial cleft fistulae or cysts, preauricular pits, ear malformations, hearing loss, and renal anomalies. Mutations in the human homologue of the Drosophilia eyes absent gene (EYA1) are the most common cause of BOR syndrome. In this study, we found a Korean family showing clinical features of the disease. Mutation analysis of the EYA1 gene revealed a novel one-base-pair deletion resulting in truncated protein (c.321delT; p.Ala107fs). This is the first report of BOR syndrome caused by deletion mutation of the EYA1 gene in Korea.</P>
Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage.
Lee, Eun Kyung,Bae, Gyu-Un,You, Jueng Soo,Lee, Jae Cheol,Jeon, Yae Jee,Park, Jong Woo,Park, Jae Hyun,Ahn, Seong Hoon,Kim, Yong Kee,Choi, Wahn Soo,Kang, Jong-Sun,Han, Gyoonhee,Han, Jeung-Whan American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.5
<P>Functional dedifferentiation of lineage-committed cells toward pluripotency may have a great potential in regenerative medicine. Reversine has been shown to induce dedifferentiation of multiple terminally differentiated mesodermal origin cells, which are capable of being directed to differentiate into other cell types within mesodermal lineages. However, the possibilities of these cells to give rise to other lineages have not been examined. Here we show that large scale gene expression profiling of reversine-treated C2C12 myoblasts identifies a subset of up-regulated genes involved in specification of neuroectodermal as well as mesodermal lineages. Reversine treatment leads to up-regulation of priming genes of neuroectodermal lineages, such as Ngn2, Nts, Irx3, Pax7, Hes1, and Hes6, through active histone modifications in the promoter regions of these genes. Additionally, reversine increases the expression of markers for other cell types of mesodermal lineages, Ogn and apoE, via inducing active histone modifications, while down-regulating the myogenic basic helix-loop-helix factor, MyoD, via repressive histone modifications. Consistent with up-regulation of these genes, reversine-treated C2C12 myoblasts redifferentiate into neural as well as mesodermal lineages, under appropriate stimuli. Taken together, these results indicate that reversine induces a multipotency of C2C12 myoblasts via inducing a specific combination of active histone modifications. Collectively, our findings provide a mechanistic rationale for the application of reversine to dedifferentiation of somatic cells.</P>
Lee, Ku-Tak,Choi, Boo-Hyun,Woo, Jong-Un,Kang, Jeong-Su,Paik, Jong-Hoo,Chu, Byoung-Uck,Nahm, Sahn Elsevier 2018 Journal of the European Ceramic Society Vol.38 No.12
<P><B>Abstract</B></P> <P>ZnS nanopowders annealed at low temperatures (≤550 °C) have a pure cubic structure, while a small amount of hexagonal phase formed in specimens annealed at temperatures ≥700 °C. The particle sizes of the ZnS nanopowders increased with the annealing temperature. ZnS ceramics that were sintered using ZnS nanopowders annealed at low temperatures (≤550 °C) exhibited low transmittance, because of their porous microstructure. ZnS ceramics that were synthesized using ZnS powders annealed at high temperatures (≥800 °C) containing large agglomerated particles, also exhibited low transmittance, due to the presence of a liquid phase. A carbonate absorption band was found from the ZnS ceramics with small grains, because carbon ions diffused from the graphite mold into the ZnS ceramics during sintering, probably through the grain boundaries, and formed carbonates. A ZnS ceramic that was sintered at 1020 °C using the nanopowders annealed at 750 °C exhibited dense microstructure, with a large transmittance, 68%, in the wavelength range 6.0–12 μm.</P>