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RISS 인기검색어
- 검색키워드
- 저자 : Laura Matteo (검색결과 5 건)
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Modelling of a Centrifugal Pump Using the CATHARE-3 One-dimensional Transient Rotodynamic Pump Model
Laura Matteo,Antoine Dazin,Nicolas Tauveron 한국유체기계학회 2019 International journal of fluid machinery and syste Vol.12 No.2
The CATHARE-3 predictive transient rotodynamic pump model and its validation in single-phase first quadrant conditions at component scale are presented in this paper. One-dimensional discretization and resolution of governing equations are made according to a mean flow path along all pump parts (suction, impeller, diffuser, volute and discharge pipe), what makes the model original compared to classical 1D models. The model is first verified by comparison to the Euler equation of turbomachinery results. Then, qualification of the model is carried out in steady and transient conditions by comparison to available experimental data. Head and torque characteristics curves are well predicted at different rotational speeds. Finally, a fast startup transient is simulated. Results are satisfactory as the difference between the experimental and modelled non-dimensionalized head is less than 10% of the final value during the whole startup.
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Francesca De Cagna,Laura Fusar-Poli,Stefano Damiani,Matteo Rocchetti,Gianluca Giovanna,Alessia Mori,Pierluigi Politi,Natascia Brondino 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1
Several studies have demonstrated the neuromodulating function of oxytocin (OT) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression. Consequently, intranasal OT (IN-OT) has been proposed as a potential treatment of anxiety and depressive disorders. The present systematic review aimed to summarize the randomized controlled trials (RCTs) evaluating the effect of IN-OT on anxiety and depressive symptoms. Overall, 15 studies were included, involving patients with social anxiety disorders (7 studies), arachnophobia (1), major depression (3) or post-natal depression (4), and mainly evaluating single-dose administrations of IN-OT. Results showed no significant effects on core symptomatology. Five crossover studies included functional magnetic resonance imaging investigation: one trial showed reduced amygdala hyper-reactivity after IN-OT in subjects with anxiety, while another one showed enhanced connectivity between amygdala and bilateral insula and middle cingulate gyrus after IN-OT in patients but not in healthy controls. More studies are needed to confirm these results. In conclusion, up to date, evidence regarding the potential utility of IN-OT in treating anxiety and depression is still inconclusive. Further RCTs with larger samples and long-term administration of IN-OT are needed to better elucidate its potential efficacy alone or in association with standard care.
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Cohexisting Medullary and Papillary Thyroid Cancer
Gianlorenzo Dionigi,Maria Laura Tanda,Eliana Piantanida,Silvia Uccella,Stefano La Rosa,Davide Inversini,Matteo Lavazza,Vincenzo Pappalardo,Fausto Sessa,Liu Xiaoli 대한갑상선-내분비외과학회 2017 The Koreran journal of Endocrine Surgery Vol.17 No.2
Purpose: Papillary thyroid carcinomas (PTCs) and medullary thyroid carcinomas (MTCs) have always been considered different in terms of their incidence rates, cell origins, and histopathological features. Simultaneous occurrence of both disease entities is very rare. Methods: We describe a series of cases with simultaneous MTC and PTC occurrences in the thyroid gland. Results: From 2,897 patients (mean age, 49.2±12.5; 81% women) who underwent thyroidectomy for cancer between 2000 and 2015, we reviewed 11 cases of simultaneous occurrence of MTCs and PTCs. Multifocal PTC with simultaneous MTC was detected in 5 of the 11 cases (45%). Of these PTC patients, 2 had 2 foci, 2 had 3 foci, and 1 had 4 foci. There was 1 case of multifocal MTC with solitary PTC. One patient presented with “composite thyroid carcinoma” with mixed features of MTCs and PTCs. Eight patients (72%) presented an association with diffuse lymphocytic thyroiditis. The sizes of the tumors were 1.95±0.23 cm vs. 1.20±0.20 cm for PTCs and MTCs, respectively (P=0.531). The prevalence of extrathyroidal extension was 33.1% vs. 30.2% for PTCs and MTCs, respectively (P=0.282). All patients underwent total thyroidectomy and central neck node dissection. Radio iodine was delivered to 44% of patients. Follow-up review revealed 9 disease-free patients and 1 with local neck recurrence, while 1 patient died due to non-thyroid reasons. Conclusion: There are only 30 reports describing a total of 50 cases in the English literature regarding concurrent PTC and MTC in the same gland. This study represents one of the largest case series. Whether the incidence of another cancer in these patients is coincidental, or due to the possible activation of a common tumorigenic pathway for both follicular and parafollicular thyroid cells, remains to be elucidated.
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Images from 18F-DOPA Scan in Congenital Hyperinsulinism: Not Always a Clue for Diagnosis
Evelina Maines,Luca Giacomello,Mirko D’Onofrio,Matteo Salgarello,Rossella Gaudino,Laura Baggio,Andrea Bordugo 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in childhood (Horm Res 70:65-72, 2008; J Clin Endocr Metab 93:869- 875, 2008). 18−Fluoro-L-dihydroxy-phenylalanine (18FDOPA) positron emission tomography (PET) can detect areas of increased activity in the pancreas and may differentiate focal from diffuse CHI (J Clin Endocr Metab 93:869-875, 2008; Radiology 253:216-222, 2009). We here report the case of a girl who complained of recurrent episodes of severe hypoglycaemia despite previous partial pancreatectomy. To evaluate the need for additional surgical intervention, we performed 18F-DOPA PET/ computed tomography (CT), which showed a focal lesion corresponding to the anatomical region of the pancreatic tail. On the other hand, abdominal magnetic resonance imaging (MRI) clearly demonstrated that the 18F-DOPA uptake was in a loop of bowel occupying the previous surgical bed. Our case highlights that bowel uptake can be a possible pitfall in the interpretation of 18F-DOPA PET/CT in children affected by CHI, suggesting that when 18F-DOPA PET/CT results do not fit the clinical picture, magnetic resonance imaging (MRI) may allow a more accurate correlation of the radiotracer activity with the underlying anatomical or pathological structure.
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