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( Won Jeong Hwang ),( Su Jin Hwang ),( Kyoungsuk Lee ),( Yi Jung Chung ) 물리치료재활과학회 2013 Physical therapy rehabilitation science Vol.2 No.2
Objective: Clinical measures that quantify upper extremity function are needed for the accurate evaluation of patients and to plan an intervention strategy. The purpose of this study was to examine the relationship between the Unified Parkinson`s Disease Rating Scale (UPDRS)-Motor Exam and upper extremity performance as a quantifying clinical tool of upper extremity function in persons with Parkinson`s disease. Design: Cross-sectional study. Methods: Thirty-two idiopathic Parkinson`s Disease persons participated in this study. To investigate the relationship between the UPDRS-motor exam, Box and Block test (BBT), and Action Research Arm Test (ARAT) by two physical therapists. The examination took up to 1 hour, and the participants were invited to rest between each clinical measure in order to minimize the effects of fatigue. Clinical measures were assessed while the subjects were in the “on” phase of their medication cycle, generally 1-3 hour after taking their anti-Parkinson`s medications. Results: In more affected side, the UPDRS-motor exam was significantly negative correlated with the BBT (p<0.05) but it was not significantly correlated with the ARAT. In less affected side, only positively correlation was significantly shown between BBT and ARAT (p<0.05). On the other hand, between BBT and ARAT were not significantly correlated with the UPDRS-motor exam. Conclusions: The UPDRS-motor exam is effective tool which was significantly correlated with manual dexterity in more affected upper extremity. But The UPDRS-motor exam is not effective tool in less affected upper extremity.
Mechanistic Investigation of Water Oxidation Catalyzed by Uniform, Assembled MnO Nanoparticles
Jin, Kyoungsuk,Seo, Hongmin,Hayashi, Toru,Balamurugan, Mani,Jeong, Donghyuk,Go, Yoo Kyung,Hong, Jung Sug,Cho, Kang Hee,Kakizaki, Hirotaka,Bonnet-Mercier, Nadè,ge,Kim, Min Gyu,Kim, Sun Hee,Nakamu American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.6
<P>The development of active water oxidation catalysts is critical to achieve high efficiency in overall water splitting. Recently, sub 10 nm-sized monodispersed partially oxidized manganese oxide nanoparticles were shown to exhibit not only superior catalytic performance for oxygen evolution, but also unique electrokinetics, as compared to their bulk counterparts. In the present work, the water oxidizing mechanism of partially oxidized MnO nanoparticles was investigated using integrated in situ spectroscopic and electrokinetic analyses. We successfully demonstrated that, in contrast to previously reported manganese (Mn)-based catalysts, Mn(III) species are stably generated on the, surface of MnO nanoparticles via a proton-coupled electron transfer pathway. Furthermore, we confirmed as to MnO nanoparticles that the one-electron oxidation step from Mn(II) to Mn(III) is no longer the rate-determining step for water oxidation and that Mn(W)=O species are generated as reaction intermediates during catalysis.</P>
Jin, Kyoungsuk,Park, Jimin,Lee, Joohee,Yang, Ki Dong,Pradhan, Gajendra Kumar,Sim, Uk,Jeong, Donghyuk,Jang, Hae Lin,Park, Sangbaek,Kim, Donghun,Sung, Nark-Eon,Kim, Sun Hee,Han, Seungwu,Nam, Ki Tae American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.20
<P>The development of a water oxidation catalyst has been a demanding challenge in realizing water splitting systems. The asymmetric geometry and flexible ligation of the biological Mn<SUB>4</SUB>CaO<SUB>5</SUB> cluster are important properties for the function of photosystem II, and these properties can be applied to the design of new inorganic water oxidation catalysts. We identified a new crystal structure, Mn<SUB>3</SUB>(PO<SUB>4</SUB>)<SUB>2</SUB>·3H<SUB>2</SUB>O, that precipitates spontaneously in aqueous solution at room temperature and demonstrated its high catalytic performance under neutral conditions. The bulky phosphate polyhedron induces a less-ordered Mn geometry in Mn<SUB>3</SUB>(PO<SUB>4</SUB>)<SUB>2</SUB>·3H<SUB>2</SUB>O. Computational analysis indicated that the structural flexibility in Mn<SUB>3</SUB>(PO<SUB>4</SUB>)<SUB>2</SUB>·3H<SUB>2</SUB>O could stabilize the Jahn–Teller-distorted Mn(III) and thus facilitate Mn(II) oxidation. This study provides valuable insights into the interplay between atomic structure and catalytic activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-20/ja5026529/production/images/medium/ja-2014-026529_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja5026529'>ACS Electronic Supporting Info</A></P>
Precocious Expression of Drosophila Rbp9 Inhibits Ovarian Germ Cell Proliferation
Jeongsil Kim-Ha,Kyoungsuk Jeong 한국분자세포생물학회 2004 Molecules and cells Vol.18 No.2
We previously reported that Rbp9 is expressed in the germarium region as soon as germ cells complete mitosis and form 16 interconnected cystocytes. Mutation of Rbp9 caused over-proliferation of cystocytes and generated an ovarian tumor phenotype. This led us to conclude that Rbp9 either inhibits cell proliferation or is required for cell differentiation. To examine the role of Rbp9, we over-expressed it ectopically in germline stem cells and early stage cystocytes that had not yet formed 16 cell clusters. The egg chambers of the newly eclosed transgenic flies looked normal. However, on day 12, most of the developing egg chambers had disappeared and only the germarium region remained. Staining of the Rbp9 over-expressing transgenic ovaries with mitosis markers revealed almost no mitotic divisions in the transgenic germaria. Further examination of these cystocytes with HTS [hu-li tai shao protein], which labels the fusome structure, revealed that the cells in the germarium region consisted of stem cells and cystocytes that had not yet completed four mitotic divisions. These observations suggest that precocious expression of Rbp9 inhibits cystocyte proliferation. Therefore the precise onset of Rbp9 expression in germarium region 2a is critical for inhibiting their further proliferation and achieving their correct differentiation.
A New Water Oxidation Catalyst: Lithium Manganese Pyrophosphate with Tunable Mn Valency
Park, Jimin,Kim, Hyunah,Jin, Kyoungsuk,Lee, Byung Ju,Park, Yong-Sun,Kim, Hyungsub,Park, Inchul,Yang, Ki Dong,Jeong, Hui-Yun,Kim, Jongsoon,Hong, Koo Tak,Jang, Ho Won,Kang, Kisuk,Nam, Ki Tae American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.11
<P>The development of a water oxidation catalyst has been a demanding challenge for the realization of overall water-splitting systems. Although intensive studies have explored the role of Mn element in water oxidation catalysis, it has been difficult to understand whether the catalytic capability originates mainly from either the Mn arrangement or the Mn valency. In this study, to decouple these two factors and to investigate the role of Mn valency on catalysis, we selected a new pyrophosphate-based Mn compound (Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB>), which has not been utilized for water oxidation catalysis to date, as a model system. Due to the monophasic behavior of Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> with delithiation, the Mn valency of Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> (<I>x</I> = 0.3, 0.5, 1) can be controlled with negligible change in the crystal framework (e.g., volume change ∼1%). Moreover, inductively coupled plasma mass spectrometry, X-ray photoelectron spectroscopy, ex-situ X-ray absorption near-edge structure, galvanostatic charging–discharging, and cyclic voltammetry analysis indicate that Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> (<I>x</I> = 0.3, 0.5, 1) exhibits high catalytic stability without additional delithiation or phase transformation. Notably, we observed that, as the averaged oxidation state of Mn in Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> increases from 2 to 3, the catalytic performance is enhanced in the series Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < Li<SUB>1.7</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < Li<SUB>1.5</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < LiMnP<SUB>2</SUB>O<SUB>7</SUB>. Moreover, Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> itself exhibits superior catalytic performance compared with MnO or MnO<SUB>2</SUB>. Our study provides valuable guidelines for developing an efficient Mn-based catalyst under neutral conditions with controlled Mn valency and atomic arrangement.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-11/ja410223j/production/images/medium/ja-2013-10223j_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja410223j'>ACS Electronic Supporting Info</A></P>
Biofunctionalized Ceramic with Self-Assembled Networks of Nanochannels
Jang, Hae Lin,Lee, Keunho,Kang, Chan Soon,Lee, Hye Kyoung,Ahn, Hyo-Yong,Jeong, Hui-Yun,Park, Sunghak,Kim, Seul Cham,Jin, Kyoungsuk,Park, Jimin,Yang, Tae-Youl,Kim, Jin Hong,Shin, Seon Ae,Han, Heung Nam American Chemical Society 2015 ACS NANO Vol.9 No.4
<P>Nature designs circulatory systems with hierarchically organized networks of gradually tapered channels ranging from micrometer to nanometer in diameter. In most hard tissues in biological systems, fluid, gases, nutrients and wastes are constantly exchanged through such networks. Here, we developed a biologically inspired, hierarchically organized structure in ceramic to achieve effective permeation with minimum void region, using fabrication methods that create a long-range, highly interconnected nanochannel system in a ceramic biomaterial. This design of a synthetic model-material was implemented through a novel pressurized sintering process formulated to induce a gradual tapering in channel diameter based on pressure-dependent polymer agglomeration. The resulting system allows long-range, efficient transport of fluid and nutrients into sites and interfaces that conventional fluid conduction cannot reach without external force. We demonstrate the ability of mammalian bone-forming cells placed at the distal transport termination of the nanochannel system to proliferate in a manner dependent solely upon the supply of media by the self-powering nanochannels. This approach mimics the significant contribution that nanochannel transport plays in maintaining living hard tissues by providing nutrient supply that facilitates cell growth and differentiation, and thereby makes the ceramic composite “alive”.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-4/acsnano.5b01052/production/images/medium/nn-2015-010525_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b01052'>ACS Electronic Supporting Info</A></P>
Tyrosine mediated 2D peptide assembly and its role as a bio-inspired catalytic scaffold
Ki Tae Nam,Yoon-Sik Lee,Hyung-Seok Jang,Jung-Ho Lee,Yong-Sun Park,Jimin Park,Tae-Youl Yang,Kyoungsuk Jin,Jae Hun Lee,Sunghak Park,Jae Muoyng You,Ki-Woong Jeong,Areum Shin,In-Seon Oh,Min-Kyung Kwon,Yon 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.4