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      • SCIESCOPUSKCI등재

        The Value of Submitting Multiple Sputum Specimens for Accurate Diagnosis of Pulmonary Tuberculosis

        Kisa, Ozgul,Albay, Ali,Baylan, Orhan,Doganci, Levent The Microbiological Society of Korea 2002 The journal of microbiology Vol.40 No.4

        Is a multiple number of sputum specimens necessary for the diagnosis of pulmonary tuberculosis? To answer this question, 6844 respiratory specimens obtained from previously untreated patients suspected of having pulmonary tuberculosis between 1998 and 2001 were evaluated retrospectively. All of the specimens were evaluated by acid fast bacilli smear and BACTEC 460 TB culture system. A total of 785 (11%) specimens from 353 patients were positive for Mycobacterium tuberculosis complex. For 76% (270/353) of these patients the organism was detected from sputum specimens collected sequentially for daily basis. Mycobacterium tuberculosis was isolated in the first, second and third samples of the majority (98%,195/199) of patients who had three or more sputum samples sent to the laboratory. Our results indicate that, we could carry out Mycobacterium tuberculosis isolation in the first, second and third sputum samples of the overwhelming majority of the patients and the diagnostic value of four or more sputum specimens submitted to the laboratory was very low (2%). We recommend that, for definitive and cost-effective diagnosis of pulmonary tuberculosis at least three sequential sputum specimens be collected for all patients suspected pulmonary tuberculosis.

      • SCIESCOPUS

        Vibration and stability of axially loaded cracked beams

        Kisa, Murat Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.3

        Structural defects such as cracks are the source of local flexibilities and cause deficiencies in structural resistance. In the engineering constructions, structural elements sometimes are subjected to axial loading. Therefore, besides crack ratios and locations, influence of applied load on the stability and dynamical characteristics should also be explored. This study offers a numerical technique for the vibration and stability analysis of axially loaded cracked beams. The model merges finite element and component mode synthesis methods. Initially, stability analysis is completed and then dynamical characteristics of beams are found. Very good conformities between outcomes of the current study and those in literature, give the confidence that proposed method is reliable and effective.

      • Inverse Design and Analysis of Supersonic Biplane

        Kisa MATSUSHIMA,Daigo MARUYAMA,Ryota NOGUCHI 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-

        With the aim of realizing a new concept of supersonic transport, aerodynamic wing design and analysis are discussed based on Computational Fluid Dynamics. A biplane airfoil originated by A. Busemann was extended to 3-D wings with a design Mach number of 1.7. Euler simulations of several biplane wing configurations were conducted. Due to the existence of wing tips, biplane wings do not perform as well as biplane airfoils. This is because the wingtip areas are affected by the three dimensionality of Mach cone integration of influenced areas. The three-dimensionality precludes the occurrence of an appropriate pressure wave interaction. Induced drag due to lift is also generated there. Thus, the wingtip area has a large drag coefficient. To overcome these problems. a tapered wing was herein considered. Then, Aerodynamic design of wing section shapes of the tapered biplane wing was conducted using a recently devised inverse problem method. The designed biplane wing shows a better lift-to-drag ratio performance than the 2-D flat-plate airfoil in the range where the lift coefficient is more than 0.17. In addition, some desirable pressure wave interaction phenomena were found in the three dimensional biplane.

      • SCIESCOPUS

        Modal analysis of cracked cantilever composite beams

        Kisa, Murat,Arif Gurel, M. Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.20 No.2

        Modal analysis of cracked cantilever composite beams, made of graphite-fibre reinforced polyamide, is studied. By using the finite element and component mode synthesis methods, a numeric model applicable to investigate the vibration of cracked composite beams is developed. In this new approach, from the crack section, the composite beam separated into two parts coupled by a flexibility matrix taking into account the interaction forces. These forces are derived from the fracture mechanics theory as the inverse of the compliance matrix calculated with the proper stress intensity factors and strain energy release rate expressions. Numerical results are obtained for modal analysis of composite beams with a transverse non-propagating open crack, addressing the effects of the location and depth of the crack, and the volume fraction and orientation of the fibre on the natural frequencies and mode shapes. By means of modal data, the position and dimension of the defect can be found. The results of the study confirmed that presented method is suitable for the vibration analysis of cracked cantilever composite beams. Present technique can be easily extended to composite plates and shells.

      • SCIEKCI등재

        Responses of the phenolic compounds of Zea mays under heavy metal stress

        Kisa, Dursun,Elmastas, Mahfuz,Ozturk, Lokman,Kayir, Omer The Korean Society for Applied Biological Chemistr 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.6

        Heavy metal toxicity is one of the major abiotic stresses caused by physiological and biochemical changes. Plants have evolved various phytochemical defense mechanisms to cope with this abiotic stress conditions. Phenolic compounds are one of the stress responses and have multiple roles in respect to adaptation of plants to the environment. In the present study, we aimed to evaluate the differential accumulation of various phenolics with HPLC in the leaves of corn exposed to increasing heavy metal doses in the plant growth medium. The application of Cd, Cu, and Pb increased the total phenolics in all treatments compared to control groups. Chlorogenic acid and rutin were the main phenolic compounds in respect to quantifying. However, the contents of caffeic acid, ferulic acid, and vanillic acid were comparatively lower than chlorogenic acid and rutin in all samples. The content of chlorogenic acid significantly increased and rutin slightly increased in the treatment of the heavy metals. The levels of caffeic acid and ferulic acid significantly decreased in all exposures of heavy metals compared to control groups. The content of vanillic acid changed according to heavy metal types and doses in the leaves of corn, and the low doses of Pb and Cd increased the level of vanillic acid. We show that there is a positive correlation with the total phenolic content and chlorogenic acid when the corn is exposed to Pb. Moreover, there are negative correlations between total phenolic compound and caffeic acid, ferulic acid in the application of Cu and Cd.

      • SCIESCOPUS

        Free vibration analysis of multiple open-edge cracked beams by component mode synthesis

        Kisa, M.,Brandon, J.A. Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.10 No.1

        This study is an investigation of the effect of cracks on the dynamical characteristics of a cantilever beam, having multiple open-edge transverse cracks. The flexibilities due to crack have been identified for several crack depths and locations. In the study the finite element method and component mode synthesis methods are used. Coupling the components is performed by a flexibility matrix taking into account the interaction forces. Each component is modelled by cantilever beam finite elements with two nodes and three degrees of freedom at each node. The results obtained lead to conclusion that, by using the drop in the natural frequencies and the change in the mode shapes, the presence and nature of cracks in a structure can be detected. There is some counter-evidence, however, that the effects due to multiple cracks may interact to make detection more difficult than for isolated cracks.

      • Supersonic Wing Design Method Using an Inverse Problem for Practical Application

        Kisa Matsushima,Shoji Sakashita,Kazuhiro Nakahashi 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-

        A wing design system using an inverse problem has many advantages, The system can design with much smaller number of now simulations than generic design system. Moreover it can use many geometrical control points, So it was used in “NEXST-I” project and successfully designed the NLF wing. However it needs to be improved to apply this method to critical or severe design problems, One of the required improvements is in accuracy in determining geometric correction values, In this research. we aim to improve the design system by introducing high order term of the geometric perturbation, The redesign or a known wing was conducted to validate the modified design system, It is preliminary confirmed that the modified one has more accuracy and robustness than the original one.

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