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Kim, Hyeong Seok,Jang, Jin-Young,Han, Youngmin,Lee, Kyoung Bun,Joo, Ijin,Lee, Doo-Ho,Kim, Jae Ri,Kim, Hongbeom,Kwon, Wooil,Kim, Sun-Whe The Korean Surgical Society 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.4
<P><B>Purpose</B></P><P>Neoadjuvant treatment may provide improved survival outcomes for patients with borderline resectable pancreatic cancer (BRPC). The purpose of this study is to evaluate the clinical outcomes of neoadjuvant treatment and to identify prognostic factors.</P><P><B>Methods</B></P><P>Forty patients who met the National Comprehensive Cancer Network definition of BRPC and received neoadjuvant treatment followed by surgery between 2007 and 2015 were evaluated. Prospectively collected clinicopathological outcomes were analyzed retrospectively.</P><P><B>Results</B></P><P>The mean age was 61.7 years and the male-to-female ratio was 1.8:1. Twenty-six, 3, and 11 patients received gemcitabine-based chemotherapy, 5-fluorouracil, and FOLFIRINOX, respectively. The 2-year survival rate (2YSR) was 36.6% and the median overall survival (OS) was 20 months. Of the 40 patients, 34 patients underwent resection and the 2YSR was 41.2% while the 2YSR of patients who did not undergo resection was 16.7% (P = 0.011). The 2YSR was significantly higher in patients who had partial response compared to stable disease (60.6% <I>vs</I>. 24.3%, P = 0.038), in patients who did than did not show a CA 19-9 response after neoadjuvant treatment (40.5% <I>vs</I>. 0%, P = 0.039) and in patients who did than did not receive radiotherapy (50.8% <I>vs</I>. 25.3%, P = 0.036). Five patients had local recurrence and 17 patients had systemic recurrence with a median disease specific survival of 15 months.</P><P><B>Conclusion</B></P><P>Neoadjuvant treatment followed by resection is effective for BRPC. Pancreatectomy and neoadjuvant treatment response may affect survival. Effective systemic therapy is needed to improve long-term survival since systemic metastasis accounts for a high proportion of recurrence.</P>
Kim, Kyung Hwan,Muniyappan, Srinivasan,Oang, Key Young,Kim, Jong Goo,Nozawa, Shunsuke,Sato, Tokushi,Koshihara, Shin-ya,Henning, Robert,Kosheleva, Irina,Ki, Hosung,Kim, Youngmin,Kim, Tae Wu,Kim, Jeongh American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.16
<P/><P>Proteins serve as molecular machines in performing their biological functions, but the detailed structural transitions are difficult to observe in their native aqueous environments in real time. For example, despite extensive studies, the solution-phase structures of the intermediates along the allosteric pathways for the transitions between the relaxed (R) and tense (T) forms have been elusive. In this work, we employed picosecond X-ray solution scattering and novel structural analysis to track the details of the structural dynamics of wild-type homodimeric hemoglobin (HbI) from the clam <I>Scapharca inaequivalvis</I> and its F97Y mutant over a wide time range from 100 ps to 56.2 ms. From kinetic analysis of the measured time-resolved X-ray solution scattering data, we identified three structurally distinct intermediates (I<SUB>1</SUB>, I<SUB>2</SUB>, and I<SUB>3</SUB>) and their kinetic pathways common for both the wild type and the mutant. The data revealed that the singly liganded and unliganded forms of each intermediate share the same structure, providing direct evidence that the ligand photolysis of only a single subunit induces the same structural change as the complete photolysis of both subunits does. In addition, by applying novel structural analysis to the scattering data, we elucidated the detailed structural changes in the protein, including changes in the heme–heme distance, the quaternary rotation angle of subunits, and interfacial water gain/loss. The earliest, R-like I<SUB>1</SUB> intermediate is generated within 100 ps and transforms to the R-like I<SUB>2</SUB> intermediate with a time constant of 3.2 ± 0.2 ns. Subsequently, the late, T-like I<SUB>3</SUB> intermediate is formed via subunit rotation, a decrease in the heme–heme distance, and substantial gain of interfacial water and exhibits ligation-dependent formation kinetics with time constants of 730 ± 120 ns for the fully photolyzed form and 5.6 ± 0.8 μs for the partially photolyzed form. For the mutant, the overall kinetics are accelerated, and the formation of the T-like I<SUB>3</SUB> intermediate involves interfacial water loss (instead of water entry) and lacks the contraction of the heme–heme distance, thus underscoring the dramatic effect of the F97Y mutation. The ability to keep track of the detailed movements of the protein in aqueous solution in real time provides new insights into the protein structural dynamics.</P>
2016 JELL Forum: A Roundtable “The Interface of Literature and Economy”
( Youngmin Kim ) 한국영어영문학회 2017 영어 영문학 Vol.63 No.3
The world has entered into the age of universal economic crisis. In this second decade of the twenty-first century, the long shadow of economic downturn and instability looms over not only traditionally underdeveloped countries and regions, but the superpowers of global economy, such as the US, the EU, and China. At the time when economy is at once a global priority and the source of worldwide anxiety, fear, and uncertainty, and when economic crisis seems to accelerate the crisis of humanities and higher education, the ELLAK organizes an international forum to reconfigure the interface of literature and economy and redefine the social parameters of literary studies. The nexus between literature and economy has never been so dynamic and convoluted as it is today. The theme of the Roundtable was “The Interface of Literature and Economy.” The Chair of the session was Youngmin Kim, the Editor-in Chief of The Journal of English Language and Literature. 10 keynote speakers at the 2016 ELLAK Convention were invited to this roundtable on The Interface of Literature and Economy. The following transcription includes the dialogues of the seven discussants. Their dialogues, which were delivered orally in this roundtable before a large audience, were videotaped and transcribed, and the whole manuscripts were reviewed by the editor. Then, the editor has slightly edited the transcription to change the natural colloquial expressions into readable texts.
Kim, Tae Wu,Lee, Jae Hyuk,Choi, Jungkweon,Kim, Kyung Hwan,van Wilderen, Luuk J.,Guerin, Laurent,Kim, Youngmin,Jung, Yang Ouk,Yang, Cheolhee,Kim, Jeongho,Wulff, Michael,van Thor, Jasper J.,Ihee, Hyotch American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.6
<P>Photoreceptor proteins play crucial roles in receiving light stimuli that give rise to the responses required for biological function. However, structural characterization of conformational transition of the photoreceptors has been elusive in their native aqueous environment, even for a prototype photoreceptor, photoactive yellow protein (PYP). We employ pump probe X-ray solution scattering to probe the structural changes that occur during the photocycle of PYP in a wide time range from 3.16 mu s to 300 ms. By the analysis of both kinetics and structures of the intermediates, the structural progression of the protein in the solution phase is vividly visualized. We identify four structurally distinct intermediates and their associated five time constants and reconstructed the molecular shapes of the four intermediates from time-independent, species-associated difference scattering curves. The constructed structures of the intermediates show the large conformational changes such as the protrusion of N-terminus, which is restricted in the crystalline phase due to the crystal contact and thus could not be clearly observed by X-ray crystallography. The protrusion of the N-terminus and the protein volume gradually increase with the progress of the photocycle and becomes maximal in the final intermediate, which is proposed to be the signaling state. The data not only reveal that a common kinetic mechanism is applicable to both the crystalline and the solution phases, but also provide direct evidence for how the sample environment influences structural dynamics and the reaction rates of the PYP photocycle.</P>
Shape- and Composition-Sensitive Activity of Pt and PtAu Catalysts for Formic Acid Electrooxidation
Kim, Youngmin,Kim, Hyung Ju,Kim, Yong Seok,Choi, Sung Mook,Seo, Min Ho,Kim, Won Bae American Chemical Society 2012 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.116 No.34
<P>In this work, we have probed the shape- and composition-dependent activities of Pt and PtAu catalysts for formic acid electrooxidation. Pt-based hollow nanostructures such as Pt hollow nanospheres (Pt HNSs), Pt nanotubes (Pt NTs), and PtAu alloy nanotubes (PtAu NTs) with controlled Pt:Au compositions are successfully prepared via a galvanic replacement process using sacrificial Ag templates. The physicochemical properties of these Pt and PtAu catalysts are confirmed by scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy techniques. The electrochemical activities of these hollow structured catalysts are compared for formic acid oxidation by cyclic voltammetry and chronoamperometry methods. Relative to the commercial Pt black and Pt/C nanoparticle catalysts, the hollow nanostructured Pt materials (Pt HNS, Pt NT) exhibit enhanced catalytic activities due to structural effects. Moreover, the bimetallic PtAu NT series shows improved catalytic activities over the monometallic Pt catalysts due to compositional effects. The present study demonstrates that the catalytic activity and the extent of surface poisoning are strongly dependent on both the structural and compositional variations of the nanostructured electrocatalysts, as shown by a systemically prepared series of nanostructured catalysts for formic acid oxidation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-34/jp3054795/production/images/medium/jp-2012-054795_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp3054795'>ACS Electronic Supporting Info</A></P>