Dendrosomal Curcumin Suppresses Metastatic Breast Cancer in Mice by Changing M1/M2 Macrophage Balance in the Tumor Microenvironment

Shiri, Sadaf,Alizadeh, Ali Mohammad,Baradaran, Behzad,Farhanghi, Baharak,Shanehbandi, Dariush,Khodayari, Saeed,Khodayari, Hamid,Tavassoli, Abbas Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as well as 40 and 80 mg/kg groups of DNC to investigate the involvement of macrophages in the antitumor effects of curcumin in a typical animal model of metastatic breast cancer. At the end of intervention, the tumor volume and weight were significantly reduced in DNC groups compared to control (P<0.05). Histopathological data showed the presence of macrophages in tumor and spleen tissues. Real-time PCR results showed that DNC increased the expression of STAT4 and IL-12 genes in tumor and spleen tissues in comparison with control (P<0.05), referring to the high levels of M1 macrophages. Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage. The results confirm the role of macrophages in the protective effects of dendrosomal curcumin against metastatic breast cancer in mice.

Morphological and genetic variation of thirty Iranian Dendranthema (Dendranthema grandiflfl orum) cultivars using multivariate analysis

Shirin Taghipour,Abdollah Ehtesham Nia,Hamed Khodayari,Hasan Mumivand,Mohammad Reza Shafiei 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.3

Analysis of genetic diversity in dendranthema is necessary to improve this important ornamental species. In this study, 30Dendranthema grandifl ora cultivars were assessed based on 21 phenotypic traits and 13 ISSR loci based on a completelyrandomized block design with three replications in Iran. Phenotypic traits such as plant height, lateral branch number, leafnumber, leaf area, and fl ower number had high (i.e., > 45%) phenotypic and genotypic coeffi cients of variation, indicatingthe potential of these traits for improving through targeted selection in breeding programs. All of the ISSR markers werepolymorphic, and 86 alleles were identifi ed across the cultivars. The average polymorphic information content was 0.35with a Shannon’s information index of 0.29, indicating high levels of genetic variation in the tested cultivars. The clusteranalysis based on Jaccard similarity indices (J) grouped 30 genotypes into 10 major clusters. The closest relation wasobserved between the ‘Oran’ and ‘Taban3′ cultivars (with 91% similarity), while ‘Fariborz’ and ‘Farahnaz’ cultivars werefar apart from others (with 38% similarity). All cultivars were clearly diff erentiated by their ISSR fi ngerprints. T(GA)9 and(AGC)5GA markers had the highest molecular indices, which could be used for future breeding programs of dendranthema. Eleven cultivars were classifi ed separately into four groups (A–D), and the remaining 19 cultivars were placed in the otherfour groups (E–H). The fi ndings of this study will aid in parental selection studies for hybridization programs of dendranthemain future.

MODELLING AND CONTROLLING OF CAR-FOLLOWING BEHAVIOR IN REAL TRAFFIC FLOW USING ARMAX IDENTIFICATION AND MODEL PREDICTIVE CONTROL

S. SALEHINIA,A. Ghaffari,A. KHODAYARI,M. N. KHAJAVI,F. ALIMARDANI 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.3

Nowadays, car following models, as the most popular microscopic traffic flow modeling, are increasingly being used by transportation experts to evaluate new Intelligent Transportation System (ITS) and Advanced Driver Assistance Systems (ADAS) applications. The control of car following is essential due to its safety and its operational efficiency. For this purpose, this paper builds a model of car following behavior based on ARMAX structure from a real traffic data set and presents a Model Predictive Control (MPC) controller. An important advantage of this type of control is its ability to cope with constraints on controls. Since safety and operational efficiency are constraints for car following, therefore we have recruited this type of controller in this study to deal with these constraints. Based on the relative distance and relative acceleration of each instant, the MPC predicts the future behavior of the leader vehicle (LV) and according to this behavior, the acceleration of the follower vehicle (FV) is controlled. The MPC tries to control this acceleration in a way to keep the relative distance at a safe region. To investigate the performance of the designed controller, the result of the system is compared with the behavior of human drivers with similar initial conditions. Also, some other test performances were accomplished to investigate other features such as robustness and the stability of the designed MPC. The simulation results show that the MPC controller has a behavior much safer than that of real drivers and it can provide a pleasant trip for passengers.

MODELING OF DOUBLE LANE CHANGE MANEUVER OF VEHICLES

Sadegh Arefnezhad,Ali Ghaffari,Alireza Khodayari,Sina Nosoudi 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.2

Lane change maneuver is one of most riskiest driving tasks. In order to increase the safety level of the vehicles during this maneuver, design of lane change assist systems which are based on dynamics behavior of driver-vehicle unit is necessary. Therefore, modeling of the maneuver is the first step to design the driver assistance system. In this paper, a novel method for modeling of lateral motion of vehicles in the standard double-lane-change (DLC) maneuver is proposed. A neurofuzzy model is suggested consisting of both the vehicle orientation and its lateral position. The inputs of the model are the current orientation, lateral position and steering wheel angle, while the predicted lateral position and orientation of the vehicle are the outputs. The efficiency of the proposed method is verified using both simulation results and experimental tests. The simulation and experimental maneuvers are performed in different velocities. It is shown that the proposed method can effectively reduce the undesirable effects of environmental disturbances and is significantly more accurate in comparisons with the results in the recent available papers. This method can be used to personalize the advanced driver assistance systems.

Vibration Energy Harvesting Using Piezoelectric Elements by Multi-switch Circuit with Adaptive Inductance

Salar Hatam,Saber Mohammadi,Akram Khodayari 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.11

Mechanical vibration energy harvesting using multi-switch circuit with adaptive inductance is a new method based on impedance matching between electrical circuit and mechanical vibrating system in order to maximize the harvested energy. Considering a vibrating piezoelectric element in parallel with a load resistance, the whole converted energy is not dissipated or flowed into the load resistance and a remarkable portion of this energy is stored on the internal capacitor of the piezoelectric. By connecting the vibrating piezoelectric to a special interface circuit, approximately the whole stored energy portion on the piezoelectric flows into the circuit. The proposed interface circuit contains a set of inductors in series with electronic switches that controlled by a microcontroller which always provides resonance condition in the designed frequency range. In the proposed technique, for a simulated piezoelectric generator with a constant current source in the design frequency range of 100 to 700 Hz, the harvested power of numerical analysis is 2 to 10 times (depending on frequency) more than standard method (simple resistive circuit). Harvested power in the exprimental test for a cantilever piezoelectric plate in the design frequency of 100 to 350 Hz, is 4.5 times more than standard method.

Facile and Room Temperature Preparation and Characterization of PbS Nanoparticles in Aqueous [EMIM][EtSO4] Ionic Liquid Using Ultrasonic Irradiation

M. Behboudnia,A. Habibi-Yangjeh,Y. Jafari-Tarzanag,A. Khodayari 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.1

At room-temperature, a facile, seedless, and environmentally benign green route for the synthesis of star like PbS nanoclusters at 7 min in aqueous solution of 1-ethyl-3-methylimidazolium ethyl sulfate, [EMIM] [EtSO4], room-temperature ionic liquid (RTIL), via ultrasonic irradiation is proposed. The X-ray diffraction studies display that the products are excellently crystallized in the form of cubic structure. An energy dispersive X-ray spectroscopy (EDX) investigation reveals the products are extremely pure. The absorption spectra of the product exhibit band gap energy of about 4.27 eV which shows an enormous blue shift of 3.86 eV that can be attributed to very small size of PbS nanoparticles produced and quantum confinement effect. A possible formation mechanism of the PbS nanoparticles using ultrasonic irradiation in aqueous solution of the RTIL is presented.

Facile and Room Temperature Preparation and Characterization of PbS Nanoparticles in Aqueous [EMIM][EtSO₄] Ionic Liquid Using Ultrasonic Irradiation

Behboudnia, M.,Habibi-Yangjeh, A.,Jafari-Tarzanag, Y.,Khodayari, A. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.1

At room-temperature, a facile, seedless, and environmentally benign green route for the synthesis of star like PbS nanoclusters at 7 min in aqueous solution of 1-ethyl-3-methylimidazolium ethyl sulfate, [EMIM] [$EtSO_{4}$], room-temperature ionic liquid (RTIL), via ultrasonic irradiation is proposed. The X-ray diffraction studies display that the products are excellently crystallized in the form of cubic structure. An energy dispersive X-ray spectroscopy (EDX) investigation reveals the products are extremely pure. The absorption spectra of the product exhibit band gap energy of about 4.27 eV which shows an enormous blue shift of 3.86 eV that can be attributed to very small size of PbS nanoparticles produced and quantum confinement effect. A possible formation mechanism of the PbS nanoparticles using ultrasonic irradiation in aqueous solution of the RTIL is presented.