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Personality Beliefs in Obsessive-Compulsive Disorder: How Are They Related to Symptom Severity?
Aysegul Kart,Bengu Yucens 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.8
Objective The comorbidity of obsessive-compulsive disorder (OCD) and personality disorders (PDs) is frequent but there are conflicting findings about which PDs are the most common. This study aimed to investigate the personality beliefs that exist on a more pathological level among OCD patients, to explore the association between personality beliefs and OCD severity, and to clarify the mediator effect of depression in this relationship. Methods 202 OCD patients and 76 healthy controls with similar sociodemographic features were included in the study. The Personality Belief Questionnaire-Short Form was administered to both groups. The Yale-Brown Obsessions and Compulsions Scale, Beck Depression Inventory, and the Beck Anxiety Inventory were administered only to the clinical sample. Results The dependent, histrionic, paranoid, borderline, and avoidant personality subscale scores were significantly higher in the OCD group than in the control group. There was an association only between OCD severity and narcissistic personality beliefs, also depression mediated the relationship between narcissistic personality and OCD severity. Conclusion Some personality beliefs at a pathological level are more common among OCD patients. Personality beliefs, as well as depression, should be routinely assessed, as they may affect OCD severity, help-seeking behavior, and response to treatment.
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I. Duz,S. Ozdemir Kart,I. Erdem,V. Kuzucu 한국물리학회 2018 Current Applied Physics Vol.18 No.4
Total energy calculations based on density functional theory are performed for HgSe in the ambient and pressure induced phases. The electronic exchange and correlation effects are described by employing the generalized gradient approximation together with the projector augmented wave potentials. The equation of state parameters and the phase transition paths are obtained from the energy-volume landscape and enthalpy versus pressure data, correspondingly. The observed phase transition sequence of HgSe as ZB → Cinnabar → RS → Cmcm and the final transition from Cmcm to CsCl structure predicted by the other theoretical study are confirmed by our calculations. The pressure dependence of elastic constants of the structures considered in this study is reported. Bulk modulus, shear modulus, Young's modulus, Poisson's ratio, and Debye temperature as isotropic mechanical properties are evaluated for HgSe polymorphs. Our calculations of energy band structure reveal the inverted band structure evoking that HgSe in ZB phase is a semimetal.
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Betül Çelebi-Saltik,Zeynep Haciomeroglu,Didem Kart,Hasan Hüseyin Ünal,Mustafa Özgür Öteyaka 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
Tissue engineering strategies include successful management of bone injuries with biomaterials to develop bonelikestructures. The production of natural biomaterials for this purpose helps both to ensure tissue integrity and to presentalternative products for clinical purposes. However, natural materials are mostly used together with synthetic or metallicmaterials due to their low stability and mechanical properties for bone tissue regeneration. There is a clinical need formaterial combinations that have both antimicrobial properties and the ability to increase osteogenic induction. This workaims to fabricate a nanofiber scaffold using polyurethane (PU) loaded with natural fish head powder (FHP) fromArgyrosomus regius species and copper (II) chloride (CuCl2) using the electrospinning technique in order to respond to thisclinical need. There has not been any material combination in the literature that contains these compounds, supports bonedifferentiation of stem cells, and prevents bacterial adhesion. To evaluate our composite materials morphology, chemicalstructure, wettability, and thermal analysis were studied with different techniques. Anti-adhesive properties of theStreptococcus mitis (S. mitis) on composite materials were tested with bacterial colonization, and osteogenic inductiveproperties by human bone marrow mesenchymal stem cells (hBMSCs) with and without osteogenic differentiation mediumwere performed with cell viability assay, Alizarin Red staining, Ca deposition and SEM analysis. According to FESEM-EDSand ATR_FTIR data, the additives were highly incorporated into the PU nanofibers. The produced materials had randomlyoriented nanofiber with a porosity of ~72 %. The FHP loaded nanofiber had an average diameter of ~185 nm. The swellingbehavior of FHP-loaded PU roughly decreased for 3, 5, and 7 days due to the hydrophobic character of the sample. Anincreasing percentage of FHP decreased the bacterial colonization of S. mitis. PUn-CuCl2-FHP nanofibers did not exhibit anycytotoxic effect on the hBMSCs. According to Alizarin Red Staining and Ca deposition analysis, stimulation with both thematerial and the osteogenic medium triggered the bone differentiation of the hBMSCs in a combined manner at days-14. Based on the results, it can be deduced that natural fish head is a promising additive material for fabricating bone-likebiomaterials.
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Berna Cagatay Kaya,Hasan Karadag,Ozgur Oner,Aysegul Kart,Mehmet Hakan Turkcapar 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.2
ObjectiveaaAltered serum S100B protein levels have been shown in several psychiatric disorders. Our aim was to investigate whether plasma S100B is different in patients with panic disorder (PD) when compared with controls. Our second aim was to investigate whether treatment with SSRIs have an effect on S100B levels in patients with PD. MethodsaaThe sample included 32 patients diagnosed with PD (21 women, 11 men) per DSM-IV criteria and 21 healthy controls (11 women, 10 men). S100B levels were measured with BioVendor Human S100B ELISA (Enzyme Linked Immunosorbent Assay) kit. Resultsaa14 patients were not on drug treatment (43.8%) while 18 patients were taking various SSRIs. Median S100B value was 151.7 pg/mL (minimum-maximum: 120.4–164.7 pg/mL) in the control group, 147.4 pg/mL (minimum-maximum: 138.8–154.1 pg/mL) in the drug free group and 153.0 pg/mL (minimum-maximum: 137.9–164.7 pg/mL) in the treatment group. Kruskal-Wallis analysis showed a significant diffrerence among the three groups (z=9.9, df=2, p=0.007). Follow up Mann-Whitney-U tests indicated that while the control and the patients with treatment were not significantly different (z=-0.05, p=0.96), there were significant differences between the control group and untreated patients (z=-2.6, p=0.009) and treated and untreated patients (z=-3.0, p=0.003). ConclusionaaOur results suggested that, serum S100B protein level might be decreased in untreated PD patients and that patients who were treated with SSRIs had similar S100B level to healthy controls.
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