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N. Siva Gangi Reddy,K. Madhusudana Rao,박수용,김태윤,정일두 한국고분자학회 2019 Macromolecular Research Vol.27 No.5
Being poor solubility and degradation at relatively higher pH present in the small intestine, it is very essential to develop gastro-retentive dosages for the release of curcumin. In this paper, the halloysite nanotubes (HNTs) was modified with aminopropyl trimethoxy silane (APTES) in order to increase the buoyancy of the hybrid beads through holding CO2 molecules within the pores of the beads, followed by the encapsulation of curcumin into the lumen of the HNTs. Highly porous pectin based hybrid beads were fabricated by incorporating various compositions of curcumin loaded amino silanized halloysite nanotube (MHNT) and sodium bicarbonate as CO2 generating agent. Finally, hybrid beads were crosslinked by ionotropic gelation method using calcium chloride and used to gastro retentive delivery of curcumin in sustained manner. The amino salinization of halloysite and curcumin loading into the modified halloysite were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). The highly porous nature of cross-linked hybrid beads has been confirmed with scanning electron microscopy (SEM) studies. In vitro release studies in simulated gastric fluid indicate that these new hybrid floating carriers are suitable for gastro retentive controlled release applications.
Synthesis of Alginate Based Silver Nanocomposite Hydrogels for Biomedical Applications
P. Rama Subba Reddy,하창식,K. Madhusudana Rao,K. S. V. Krishna Rao,Yury Shchipunov 한국고분자학회 2014 Macromolecular Research Vol.22 No.8
Sodium alginate and poly(acrylamide-co-N-vinylcaprolactam-co-acrylamidoglycolic acid) based dualresponsive semi-IPN hydrogels (SA-PAVA) were successfully synthesized by free radical redox polymerization. N,N'-Methylene-bis-acrylamide was used as a crosslinker and 5-fluorouracil, an anti-cancer drug, was loaded ontothese semi-IPN hydrogels via equilibrium swelling method. The hydrogels were also used as templates for the productionof silver nanoparticles by using NaBH4 as reducing agent. In order to understand the polymer-drug interactions,pristine, as well as drug loaded, SA-PAVA hydrogels were characterized by Fourier transform infrared spectroscopyand differential scanning calorimetry. The formation of silver nanoparticles was confirmed by UV-visible spectroscopy,thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy(TEM). The swelling behavior of the hydrogel was investigated in distilled water under various pH and temperatureconditions. In vitro release of 5-fluorouracil from these SA-PAVA hydrogels was carried out in gastro-intestinal fluidsdifferent temperatures. The SA-PAVA hydrogel/silver nanocomposites showed excellent anti-bacterial activitytowards Escherichia coli and Bacilli.
Sudhavani, T.J.,Reddy, N. Sivagangi,Rao, K. Madhusudana,Rao, K.S.V. Krishna,Ramkumar, Jayshree,Reddy, A.V.R. Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Novel chitosan (CS) based membrane networks were developed by solution casting and followed by crosslinking with different crosslinkers such as glutaraldehyde, urea-formaldehyde, and thiourea-formaldehyde. The developed membrane networks were designated as CS-GA, CS-UF and CS-TF. Crosslinking reaction of CS membranes was confirmed by Fourier transform infrared spectroscopy. Membrane rigidity and compactness were studied by the differential scanning calorimetry. The surface morphology of CS membranes was characterized by scanning electron microscopy. The sorption behaviour with respect to contact time, initial pH and initial metal ion concentration were investigated. The maximum adsorption capacity of CS-GA, CS-UF and CS-TF sorbents was found to be 1.03, 1.2 and 1.18 mM/g for $Cu^{2+}$ and 1.48, 1.55 and 2.18 mM/g for $Ni^{2+}$ respectively. Swelling experiments have been performed on the membrane networks at $30^{\circ}C$. Desorption studies were performed in acid media and EDTA and it was found that the membranes are reusable for the metal ion removal for three cycles. The developed membranes could be successfully used for the separation of $Cu^{2+}$ and $Ni^{2+}$ metal ions from aqueous solutions.
T. J. Sudhavani,N. Sivagangi Reddy,K. Madhusudana Rao,K. S. V. Krishna Rao,Jayshree Ramkumar,A. V. R. Reddy 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Novel chitosan (CS) based membrane networks were developed by solution casting and followed by crosslinking with different crosslinkers such as glutaraldehyde, urea-formaldehyde, and thiourea-formaldehyde. The developed membrane networks were designated as CS-GA, CS-UF and CS-TF. Crosslinking reaction of CS membranes was confirmed by Fourier transform infrared spectroscopy. Membrane rigidity and compactness were studied by the differential scanning calorimetry. The surface morphology of CS membranes was characterized by scanning electron microscopy. The sorption behaviour with respect to contact time, initial pH and initial metal ion concentration were investigated. The maximum adsorption capacity of CS-GA, CS-UF and CS-TF sorbents was found to be 1.03, 1.2 and 1.18 mM/g for Cu2+ and 1.48, 1.55 and 2.18 mM/g for Ni2+ respectively. Swelling experiments have been performed on the membrane networks at 30 oC. Desorption studies were performed in acid media and EDTA and it was found that the membranes are reusable for the metal ion removal for three cycles. The developed membranes could be successfully used for the separation of Cu2+ and Ni2+ metal ions from aqueous solutions.