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Ahn, Sung Soo,Park, Eun Seong,Shim, Joo Sung,Ha, Sang-Jun,Kim, Beom Seok,Jung, Seung Min,Lee, Sang-Won,Park, Yong-Beom,Song, Jason Jungsik BioMed Central 2017 Arthritis research & therapy Vol.19 No.-
<P><B>Background</B></P><P>Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after stimulation of peripheral blood mononuclear cells with phytohemagglutinin (PHA) in patients with lupus, according to disease activity.</P><P><B>Methods</B></P><P>This study included 118 patients with lupus who had undergone IFN-γ-releasing assays (IGRAs) to screen for tuberculosis. Data on IFN-γ production in negative (nil) and positive (mitogen with PHA) controls were collected and analysed. The difference (mitogen minus nil) was used to calculate ex vivo IFN-γ production. Disease activity was evaluated using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K). Poor hospitalisation outcome was defined as in-hospital mortality or intensive care unit admission. Associations among disease activity, poor hospitalisation outcome, and ex vivo IFN-γ production were assessed.</P><P><B>Results</B></P><P>The level of ex vivo IFN-γ production was significantly lower in patients with active systemic lupus erythematosus (SLE) (n = 64) than in those with inactive SLE (n = 54) (median 0.92 vs. 11.06 IU/mL, <I>p</I> < 0.001). Ex vivo IFN-γ production was correlated with the SLEDAI-2 K (<I>r</I> = − 0.587, <I>p</I> < 0.001). Results of multivariate logistic regression analysis showed that ex vivo IFN-γ production ≤ 7.19 IU/mL was an independent predictor for discriminating active and inactive lupus. In addition, patients with ex vivo IFN-γ production ≤ 0.40 IU/mL had more frequent poor hospitalisation outcomes than those with ex vivo IFN-γ production > 0.40 (40.0% vs. 9.3%, <I>p</I> = 0.001). The proportion of indeterminate IGRA results was higher in patients with active lupus than in those with inactive lupus (45.3% vs. 0.0%, <I>p</I> < 0.001) because of decreased ex vivo IFN-γ production.</P><P><B>Conclusions</B></P><P>Ex vivo IFN-γ production is a useful biomarker for assessing disease activity and predicting poor clinical outcomes of SLE.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s13075-017-1404-z) contains supplementary material, which is available to authorized users.</P>
Ahn, Sung Soo,Hwang, Sang Hyun,Jung, Seung Min,Lee, Sang-Won,Park, Yong-Beom,Yun, Mijin,Song, Jason Jungsik Williams & Wilkins Co 2017 Medicine Vol.96 No.34
<P><B>Abstract</B></P><P>The aim of the study was to evaluate splenic glucose metabolism in macrophage activation syndrome (MAS), characterized by overwhelming systemic inflammation. Splenic <SUP>18</SUP>F-fluorodeoxyglucose (FDG) uptake was compared in patients with MAS and sepsis using positron emission tomography/computed tomography (PET/CT).</P><P>Clinical and FDG-PET/CT findings from patients with MAS and those with culture-proven sepsis were evaluated. The standardized uptake value (SUV) for the spleen and liver were measured. The maximum of the spleen to liver SUV ratio (SLR<SUB>max</SUB>) was calculated as spleen SUV<SUB>max</SUB>/liver SUV<SUB>mean</SUB>. The radiological splenic volume was also measured, and splenic metabolic volume (MV) was defined as the total splenic volume with an SLR<SUB>mean</SUB> > 1.14. The association between clinical features, laboratory variables, and SLR<SUB>max</SUB> was analyzed.</P><P>The median SLR<SUB>max</SUB> and splenic MV were significantly higher in patients with MAS (n = 38) than they were in those with sepsis (n = 15) (SLR<SUB>max</SUB>: 1.51 vs 1.09, <I>P</I> = .001; MV: 346.0 vs 154.0, <I>P</I> = .015). Multivariate analyses revealed that SLR<SUB>max</SUB> > 1.31 was useful for discriminating between MAS and sepsis. SLR<SUB>max</SUB> positively correlated with ferritin and lactate dehydrogenase level in MAS. Furthermore, MAS patients with high splenic FDG uptake (SLR<SUB>max</SUB> > 1.72) had higher in-hospital mortality compared to those with moderate to low splenic FDG uptake (<I>P</I> = .013).</P><P>This study was the first to demonstrate that splenic FDG uptake is significantly elevated in patients with MAS compared to those with sepsis. This may be useful to differentiate between MAS and sepsis, and to predict poor prognosis in patients with MAS.</P>
ProKappa를 이용한 CASE 정보저장소의 능동적 일관성 제어 메카니즘 구현
성정식(Jungsik Sung),최진오(Jinoh Choi),홍봉희(Bonghee Hong) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.2
원시코드가 없는 CASE 도구를 wrapping 기법을 사용하여 통합하는 정보저장소에서의 능동적 일관성 유지 메카니즘을 제시한다. 도구 통합시에 능동적 데이타 교환을 지원하기 위해 도구 프로그램을 추상화한 에이전트 간의 메시지 전송 프로토콜을 사용한다. 소프트웨어 개발시 불완전 모듈의 일관성 제어를 위해 도구를 간의, 데이타 객체들 간의, 도구와 데이타 간의 관련성 시맨틱을 슬롯과 규칙의 프레디키트로 표현하여 인스턴스마다 관련성의 다양한 시맨틱을 표현할 수 있도록 한다. 그리고 관련성 시맨틱을 표현한 슬롯과 규칙, 메시지 전송 프로토콜에 의한 능동적 일관성 제어가 가능함을 보인다.
( Sung Soo Ahn ),( Taejun Yoon ),( Jason Jungsik Song ),( Yong-beom Park ),( Sang-won Lee ) 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.4
Objective. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease (AID) characterised by necrotising intravascular inflammation. Growing evidence suggests that immune system triggers altered lipid metabolism in AIDs. We investigated whether changes in lipid profile correlate with severity of disease in AAV. Methods. Seven lipid profiles were evaluated utilizing frozen serum samples from 67 patients registered in the Severance Hospital ANCA-associated VasculitidEs cohort by a chemistry autoanalyzer. The Birmingham Vasculitis Activity Score (BVAS) version 3 was used to measure patient’s assessment of global disease activity. The relationship between the BVAS with continuous variables was calculated by Pearson’s correlation analysis. Results. Thirty-five (52.2%), 19 (28.4%), and 13 (19.4%) patients were diagnosed with microscopic polyangiitis, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis, respectively. Patients’ mean age was 60.0 years, and 22 (32.8%) were male. Among the lipid profiles investigated, total cholesterol, high-density lipoprotein, and low-density lipoprotein, and apolipoprotein A1 and B were significantly associated with BVAS; apolipoprotein A1 showed the highest correlation with BVAS (r=-0.521, p<0.001), remaining consistent even in patients with new-onset disease (r=-0.430, p=0.012). Apolipoprotein A1 had the highest association with the renal manifestation score among the clinical scores comprising BVAS (r=-0.457, p<0.001). Conclusion. Decreased lipid levels, especially apolipoprotein A1, are relevant to increased AAV disease activity, and differ according to organ involvement. Measuring lipid profiles could have clinical implications regarding the assessment of global disease activity and organ involvement patterns. (J Rheum Dis 2020;27:261 -269)