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Stabilization Region of PD Controller for Unstable First Order Process with Time Delay
Juan Francisco Marquez-Rubio,Basilio del Muro-Cuéllar,José Álvarez Ramírez 제어·로봇·시스템학회 2014 International Journal of Control, Automation, and Vol.12 No.2
Time delays affect considerably the performance of the process. Moreover the stabilizing regions of the controller parameters can be difficult to compute. This work provides the stability conditions for unstable first order plus time delay (UFOPTD) systems when a PD controller is used. Also, the parametric stabilization region is obtained by means of an analysis of the characteristic quasi-polynomial. The results presented in this work show that a derivative action at the controller minimizes the effects of the time-delay achieving the stabilization of UFOPTD systems with large time-delay, in contrast with a process considering controller without derivative action. The behavior of the control strategy is illustrated with some numerical examples.
Lena Hell,Kristina Lurger,Lisa-Marie Mauracher,Ella Grilz,Christina Maria Reumiller,Georg Johannes Schmidt,Huriye Ercan,Silvia Koder,Alice Assinger,José Basilio,Johanna Gebhart,Cihan Ay,Ingrid Pabinge 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Patients with antiphospholipid syndrome (APS) are at high risk of developing venous and arterial thromboembolism (TE). The role of platelets in the pathogenesis of these prothrombotic conditions is not yet fully understood. The aim of this study was to gain mechanistic insights into the role of platelets in APS by comparing the platelet proteome between lupus anticoagulant (LA)-positive patients with (LA+TE+) and without a history of TE (LA+TE−) and healthy controls. The platelet proteome of 47 patients with LA, 31 with a history of TE and 16 without thrombotic history, and 47 healthy controls was analyzed by two-dimensional differential in-gel electrophoresis and mass spectrometry to identify disease-related proteins. Afterward, selected LA-related platelet proteins were validated by western blot and ELISA. Alterations of 25 proteins were observed between the study groups. STRING pathway analysis showed that LArelated protein profiles were involved in platelet activation, aggregation, and degranulation. For example, protein disulfide isomerase family members, enzymes that promote thrombosis, were upregulated in platelets and plasma of LA+TE+patients. Leukocyte elastase inhibitor (SERPINB1), an antagonist of neutrophil extracellular trap (NET) formation, was decreased in platelets of LA+TE+patients compared to healthy controls. Additionally, citrullinated histone H3, a NET-specific marker, was increased in plasma of LA+TE+patients. These findings suggest that decreased platelet SERPINB1 levels favor prothrombotic NETosis, especially in LA+TE+patients. Our findings reveal protein abundance changes connected to altered platelet function in LA-positive patients, thus suggesting a pathogenic role of platelets in thrombotic complications in APS.