半夏瀉心湯과 Cimetidine의 병용투여가 흰쥐의 위궤양에 미치는 영향

林鍾弼,卜鎭尤 又石大學校 1988 論文集 Vol.10 No.-

Banhasasim-tang, chinese medicine, has been used for the treatment of the gastric ulcer and cimetidine, H_2-receptor blocker, has been also used as the gastric ulcer remedy. Therefore the concurrent administration of these two drugs may increase antiulcer activities more than administrating one by one. In order to investigate antiulcer activities, some experiments were conducted. The results obtained were as follows; 1.The concurrent administration of Banhasasim-tang and cimetidine given intraperitoneally (cimetidine 50㎎/㎏+extract 300㎎/㎏ and 50㎎/㎏+500㎎/㎏), significantly inhibited Shay ulceration in rats (12 hr ligation). 2.Aspirin ulcers induced by the administration of aspirin 200㎎/㎏(p.o) to pylorus-ligated rats were inhibited by the concurrent administration of Banhassasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏, 50㎎/㎏+300㎎/㎏ and 50㎎/㎏+500㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 3.Indomethacin ulcers induced by intraperitoneal injection of indomethacin 20㎎/㎏ were inhibited by the concurrent administration of Banhasasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏. 50㎎/㎏+300㎎/㎏ and 50㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 4.The antiulcer actions by the concurrent administration of Banhansasim-tang and cimetidine against Indomethacin ulcers were more effective than those against Aspirin ulcers or shay ulcers.

납 中毒된 흰쥐의 血液에 미치는 補中益氣湯의 影響(Ⅰ)

임종필,강창수,강태욱 又石大學校 1995 論文集 Vol.17 No.-

Lead acetate and Bojungiki-tang extract, a herbal restorative were treated p.o. 40㎎/㎏ and 500㎎/㎏ respectively and concurrently to mouse, and examined blood biochemical parameters and effects of metabolic enzymes of rats. The results obtained in this study are as follows: 1. The value of aspartate aminotrasferase(AST) of lead-treated group increased while the group of concurrent administration with BIT showed significant decrease and the value of alkaline phosphatase(ALP) of lead-treated group decreased while the group of concurrent administration with BIT showed significant increase. 2. The value of δ-aminolevulinic acid dehydratase(ALAD) of lead-treated group de creased while the group of concurrent administration with BIT showed significant in crease and the values of cytochrome p-450 in liver and kidney of lead-treated group increased while the group of concurrent administration with BIT showed significant decrease. The differences (%) of aniline hydroxylase and 2-thiobarbituric acid (TBA) of lead-treated group increased while the group of concurrent administration with BIT showed significant decrease. These results on the whole indicated that concurrent administration with BIT showed significant recovery from the toxicity of lead-treated group.

비소중독된 흰쥐의 장기중 비소 축적에 미치는 팔진탕의 영향

임종필,서은실,김훈,강창수 又石大學校 1998 論文集 Vol.20 No.-

Sodium arsenate and Paljin-Tang extract, a herbal restorative were treated p.o. 20 ㎎/㎏ and 500 ㎎/㎏, respectively, and concurrently to rats, and examined the variation of body weight, the accumulation of arsenic in organs. The results obtained in this study were as follows: 1. Paljin-Tang extract (PJT) resulted in the increase of body weight and the increase ratio of body weight in arsenic-treated group was dropped but the group of concurrent administration with PJT showed significant recovery. 2. The accumulation of arsenic in liver of arsenic-treated group increased but the group of concurrent administration with PJT showed significant decrease compared with arsenic-treated group. 3. The ratio of liver weight / body weight of arsenic-treated group increased but the group of concurrent administration with PJT showed significant decrease compared with arsenic-treated group.

수점산과 Cimetidine의 병용투여가 흰쥐의 위궤양에 미치는 영향

林鍾弼,金勳 又石大學校 1991 論文集 Vol.13 No.-

SOO JEOM SAN, Chinese medicine, has been used for the treatment of gastric ulcer and CIMETIDINE, H_2-receptor blocker, has been also used as the gastric ulcer remedy. Therefore, the effect of concurrent administration of these two drugs was compared with that of either SOO JEOM SAN or CIMETIDINE. In order to investigate antiulcer activities, some experiments were conducted. Ulcers were induced by fasting and chemicals(SHAY, INDOMETHACIN, ASPIRIN, ETHANOL). The results were as follows; 1. The concurrent administration of SOO JEOM SAN and CIMETIDINE insignificantly inhibited SHAY ulceration in rats. 2. The concurrent administration SOO JEOM SAN nd CIMETIDINE was more effective on ulcers than that of only SOO JEOM SAN or only CIMETIDINE on antiulcer actions against indo-methacin-induced ulcers and aspirin-induced ulcers. 3. The concurrent administration inhibited ethanol-induced ulcers, too. 4. In pathological examination, the concurrent administration was more effective on remedy of gatric ulcer and hemorrhage than that of only SOO JEOM SAN or only CIMETIDINE.

납 中毒된 흰쥐의 肝 代謝에 미치는 補中益氣湯의 影響

임종필,서은실 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Lead acetate and Bojungiki-tang(BIT) extract, a herbal restorative were treated p.o. 40mg/kg and 500mg/kg respectively and concurrently. and examined efects of metabolic enzymes of rats. The results obtained in this study are as follows: 1. The value of protein concentration in lead-poisoned group showed significant increse while the group of concurrent administration with BIT whowed slight decrease. 2. The value of aniline hydroxylase activities in lead-poisoned group showed 32.37% of increse while the group of concurrent administration with BIT showed 3.91% at 4th week. 3. The value of TBA-value in lead-poisoned group showed 66.7% of incresed while the group of concurrent adiministration with BIT whowed 7.72% at 4th week. 4. The value of glucose-60phosphate activities in lead-poisoned group showed a little decrease. These results on the whole indicated that concurrent administration with BIT showed significant recovery from the toxicity in lead-treated group.

鉛中毒 白鼠의 毒性에 미치는 十全大補湯의 效果

林鍾弼,南宮凍 又石大學校 1993 論文集 Vol.15 No.-

Sibjeondaebo-tang has been known to have an effect on remedy of anemia. The studies were carried out to evaluate the remedical effects of Sibjeondaebo-tang on the toxicity of lead-poisoned rats. The results obtained in the studies were as follows; 1. The body weight of Pb-treated group was decreased, while the group treated with Pb-SDT(Sibjeondaebo-tang) showed significant recovery of body weight. 2. The percentage of liver weight per body weight of Pb-treated group was increased remarkably, while the group treated with Pb+SDT showed slight increase compared with control group. 3. In hematological analysis, WBC was significantly increased in Pb-treated group, while the group treated with Pb+SDT showed nearly the same value as the initial.

비소 중독된 흰쥐의 신장에 미치는 팔진탕의 영향

임종필,서은실,김훈 우석대학교 생명과학연구소 1998 생명과학연구소 논문집 Vol.2 No.-

Sodium arsenate and Paljin-Tang extract, a herbal restorative were treated p. o. 20 ㎎/㎏ and 500 ㎎/㎏, respectively, and concurrently to rats, and examined the variation of kidney weight, the accumulation of arsenic and effects of metabolic exzymes in kidney of rats. The results obtained in this study were as follows: 1. The ratio of kidney weight/ body weight of arsenic-treated group increased but the group of concurrent administration with PJT showed significant decrease. 2. The accumulation of arsenic in kidney of arsenic-treated group increased but the group of concurrent administration with PJT showed significant decrease. 3. The value of cytochrome P-450 and NADPH-cytochrome c reductase activity showed no variance, but that of protein increased in arsenic-treated group but concurrent administration with PJT showed significant recovery from the toxicity of arsenic in kidney.

芍藥甘草湯의 藥效比較 硏究

林鍾弼 又石大學校 1984 論文集 Vol.6 No.-

Pharmacological studies have been carried out to investigate the clinical efficacy of "Jagyag-gamcho-Tang" (JGT) comparing effects with those of "Jagyag-Tang"(JT), "Gamcho Tang"(GT) and some medicinal substances. JGT group showed more suppressive action on convulsion due to myelic and cerebrocortical causes than JT group or HT group, but on convulsion due to diencephalic causes JT group is most suppressive. JGT group showed nearly the same effect as aminopyrine on the analgesic action On the sedative action JGT group is most effective but not so effective as chloropromazine group. Hexobarbital sodium-induced sleeping time was prolonged significantly in JGT group in mice.

補中益氣湯이 납中毒된 흰쥐의 臟器重量에 미치는 影響

임종필,남궁동,강창수,강태욱 又石大學校 1994 論文集 Vol.16 No.-

Lead acetate and Bojungiki-tang extract, a herbal restorative were treated p. o. 40㎎/㎏ and 500㎎/㎏ respectively and concurrently to mouse, and examined variation of body weigh, accumulation of lead in organs of rats. The results obtained in this study are as follows: 1. Bojungiki-tang extract(BIT) resulted increase of body weight and the increase ratio of body weight in lead-treated group was dropped but the group of concurrent administration with BIT showed significant recovery. 2. The accumulation of lead in liver of lead-treated group increased but the group of concurrent administration with BIT showed significant decrease. 3. The ratio of liver weight/body weight of lead-treated group increased but the group of concurrent administration with BIT showed significant decrease. These results on the whole indicated that concurrent administration with BIT sowed significant recovery from the toxicity of lead-treated group.

赤芍藥과 白芍藥의 解剖學的 考察

林鐘弼,南官凍,金勳,김현주 又石大學校 1992 論文集 Vol.14 No.-

A peony is the perennial plant which comes under Paeoniaceae and classifies a white peony(Paeonia japonica MIYABE et TAKEDA) and a red one(Paeonia albiflora PALLAS). The former lays in a supply of the blood and alleviates an nerve, while the latter lays in a supply of vitality and purifies the dirt blood. They have different uses but there is little difference between them in appearance. Thus at present the white peony is used together with the red one clinically. The purpose of this thesis is to examine and compare the structural and anatomical difference in root and stem of red and white peony. This comparison has led to following conclusions: 1. The length of the vessel members of the red peony is a bit longer than that of the white one in the stem and the root. 2. The width of the vessel members is wider than that of the white one in the stem and the root. 3. There is a clear difference between the two species in which the secondary xylem in root of the red peony is discontinuous scalariform arrangement while that of the white one is continuous radial arrangement.