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오늘 본 자료
Jo, Beom-Geun,Park, No-June,Jegal, Jonghwan,Choi, Sangho,Lee, Sang,Yi, Li,Kim, Su-Nam,Yang, Min Georg Thieme Verlag KG 2019 Planta medica Vol.85 No.7
<B>Abstract</B><P> Stellera chamaejasme, also known as “Langdu”, has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murine models. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment.</P>
Near-IR Fluorescent Tracer for Glucose-Uptake Monitoring in Live Cells
Jo, Ala,Sung, June,Lee, Sanghee,Nam, Hyunsung,Lee, Hyo Won,Park, Jongmin,Kim, Hwan Myung,Kim, Eunha,Park, Seung Bum American Chemical Society 2018 Bioconjugate chemistry Vol.29 No.10
<P>Fluorescent tracers for glucose-uptake monitoring could be used as chemical tools for diagnosis and for discovery of novel therapeutic agents via the development of phenotypic screening systems. Here we present a new near-infrared fluorescent glucose tracer, Glc-SiR-CO<SUB>2</SUB>H, for monitoring the cellular glucose uptake. By conjugating glucosamine with two different silicon rhodamine fluorochromes, we found that the net charge of fluorochromes has considerable effects on cellular uptake of the probe. Competition assay with <SMALL>D</SMALL>/<SMALL>L</SMALL>-glucose as well as Western blot analysis implied GLUT-dependent uptake mechanism of this probe. Finally, Glc-SiR-CO<SUB>2</SUB>H not only differentiates cancer cells from normal cells, but also allows monitoring anticancer effects in live cells.</P> [FIG OMISSION]</BR>
Jo, Beom-Geun,Park, No-June,Jegal, Jonghwan,Choi, Sangho,Lee, Sang Woo,Jin, Hang,Kim, Su-Nam,Yang, Min Hye Elsevier 2018 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.59 No.-
<P><B>Abstract</B></P> <P> <I>Stellera chamaejasme</I> L. (family Thymelaeaceae), also known as ‘<I>Langdu</I>’, has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of <I>S</I>. <I>chamaejasme</I> and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-<I>O</I>-xylosyl(1 → 2)glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-<I>O</I>-glucoside) were isolated from the aerial parts of <I>S</I>. <I>chamaejasme</I> using chromatographic methods. Of these four compounds, stechamone most potently inhibited IL-4 production and mast cell degranulation in RBL-2H3 cells. Topical application of 0.5% stechamone improved atopic skin symptoms, including, erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening) in DNCB-treated AD mice by accelerating skin barrier recovery function and suppressing inflammatory cell infiltration. In addition, stechamone attenuated DNCB-induced increases in IL-4 (an inflammatory T<SUB>H</SUB>2 cytokine) expression and in serum IgE levels in our murine model of AD. DNCB induced AD-like skin lesions, but treatment with stechamone exhibited strong anti-atopic activity by regulating skin barrier function and reducing inflammatory responses. The results obtained suggest stechamone is a potential anti-atopic agent and treatment for skin inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new flavonoid, stechamone, was isolated from <I>Stellera chamaejasme</I>. </LI> <LI> Stechamone exhibited potent IL-4 inhibitory activity in RBL-2H3 cells. </LI> <LI> 2,4-dinitrochlorobenzene was used to induce atopic dermatitis (AD) in hairless mice. </LI> <LI> Stechamone appeared to exert strong anti-AD effects on DNCB-stimulated mice. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Characteristics of SiO2 films deposited by low temperature PECVD using TEOS/N2/O2
June Hee LEE,Geun Young YEOM,Chang Hyun JEONG,Jong Tae LIM,Nam Gil JO,Se Jin KYUNG 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.4
In this study, SiO2 thin films were deposited at room temperature by using plasma enhanced chemical vapor deposition (PECVD) driven by an inductively coupled plasma (ICP) for various with gas mixtures of TEOS/N2/O2 at a given rf power and dc bias voltage. For the gas mixture with 40 sccm of N2 in TEOS, 100 sccm of N2, and 500 sccm of O2, transparent and scratchresistant SiO2 could be deposited with a deposition rate of 30 nm/min when rf power of 500 W and a dc-bias voltage of − 350 V were applied. The characteristics of the deposited SiO2, such as the composition, the binding energy, etc., were compared with the SiO2 deposited by using thermal CVD and evaporation. We found that the SiO2 deposited using by PECVD with TEOS/N2/O2 exhibited properties typical of SiO2 deposited by using thermal CVD and evaporation. The surface roughness of the 100-nm-thick SiO2 deposited by using PECVD was similar to that of the substrate.