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Upregulated lncRNA Gm2044 inhibits male germ cell development by acting as miR-202 host gene
Meng Liang,Ke Hu,Chaofan He,Jinzhao Zhou,Yaping Liao 한국통합생물학회 2019 Animal cells and systems Vol.23 No.2
Long non-coding RNAs (lncRNAs) have been found to participate in the regulation of human spermatogenic cell development. However, little is known about the abnormal expression of lncRNAs associated with spermatogenic failure and their molecular mechanisms. Using lncRNA microarray of testicular tissue for male infertility and bioinformatics methods, we identified the relatively conserved lncRNA Gm2044 which may play important roles in non-obstructive azoospermia. The UCSC Genome Browser showed that lncRNA Gm2044 is the miR-202 host gene. This study revealed that lncRNA Gm2044 and miR-202 were significantly increased in nonobstructive azoospermia of spermatogonial arrest. The mRNA and protein levels of Rbfox2, a known direct target gene of miR-202, were regulated by lncRNA Gm2044. Furthermore, the miR- 202-Rbfox2 signalling pathway was shown to mediate the suppressive effects of lncRNA Gm2044 on the proliferation of human testicular embryonic carcinoma cells. Understanding of the molecular signalling pathways for lncRNA-regulated spermatogenesis will provide new clues into the pathogenesis and treatment of patients with male infertility.
Xu Fangmin,Fu Jinzhao,Cao HaiYan,Hu ZhiRui 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.7
In order to improve spectral efficiency and reduce power consumption for reconfigurable intelligent surface (RIS) assisted wireless communication systems, a joint design considering irregular RIS topology, RIS on-off switch, power allocation and phase adjustment is investigated in this paper. Firstly, a multi-dimensional variable joint optimization problem is established under multiple constraints, such as the minimum data requirement and power constraints, with the goal of maximizing the system energy efficiency. However, the proposed optimization problem is hard to be resolved due to its property of nonlinear nonconvex integer programming. Then, to tackle this issue, the problem is decomposed into four sub-problems: topology design, phase shift adjustment, power allocation and switch selection. In terms of topology design, Tabu search algorithm is introduced to select the components that play the main role. For RIS switch selection, greedy algorithm is used to turn off the RISs that play the secondary role. Finally, an iterative optimization algorithm with high data-rate and low power consumption is proposed. The simulation results show that the performance of the irregular RIS aided system with topology design and RIS selection is better than that of the fixed topology and the fix number of RISs. In addition, the proposed joint optimization algorithm can effectively improve the data rate and energy efficiency by changing the propagation environment.
Xiaoju Li,Luqman Chuah Abdullah,Shafreeza Sobri,Mohamad Syazarudin Md Said,Siti Aslina Hussain,Tan Poh Aun,Jinzhao Hu 대한환경공학회 2024 Environmental Engineering Research Vol.29 No.4
The air pollution process and impact mechanism of megacities located in complex terrain are particularly complex. As a typical megacity in China, Chengdu has unique topographical and meteorological conditions, and its pollution control is difficult. This study systematically elucidated the variation characteristics of six criteria air pollutants in Chengdu between 2014 and 2020. Besides, the PM<SUB>2.5</SUB>/PM<SUB>10 </SUB>and NO₂/SO₂ ratios were discussed. Furthermore, a detailed analysis of the correlation between air pollutants was carried out. Finally, the collaborative path of carbon reduction and air pollution control is discussed. The results indicated that SO₂, PM<SUB>2.5</SUB>, PM<SUB>10</SUB> and CO were significantly decreased by 62.9%, 50.8%, 45.5%, and 36.7%, respectively. PM2.5 and O3 compliance rates are very low, and O₃ increases with fluctuations. SO₂, NO₂, CO, PM showed a “U-shaped” seasonal variation, and there was a “seesaw” phenomenon between O₃ and PM2.5. The continuous changing trends also found in the ratios of PM<SUB>2.5</SUB>/PM<SUB>10</SUB> and NO₂/SO₂. The results highlight the importance of coordinated reduction of carbon emissions and pollutants in Chengdu. This research can improve the prediction accuracy of air pollution in complex terrain areas under global warming, and improve the understanding of the formation mechanism of air pollution in special terrains around the world.