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Intelligent computational design of scalene-faceted flat-foldable tessellations
Chen Yao,Lu Chenhao,Yan Jiayi,Feng Jian,Sareh Pooya 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.5
Origami tessellations can be folded from a given planar pattern into a three-dimensional object with specific geometric properties, inspiring developments in various fields of science and engineering such as deployable structures, energy absorption devices, reconfigurable robots, and metamaterials. However, the range of existing origami patterns with functional properties such as flat-foldability is rather scant, as analytical solutions to constraint equations arising in the design process are generally highly complicated. In this paper, we tackle the challenging problem of automated design of scalene-faceted flat-foldable origami tessellations using an efficient metaheuristic algorithm. To this end, this study establishes constraint curves based on compatibility conditions for all six-fold (i.e., degree-6) vertices. Subsequently, a graphical method and a particle swarm optimization (PSO) method are adopted to produce optimal origami patterns. Moreover, mountain-valley assignments for the obtained geometric designs are determined using a computational approach based on mixed-integer linear programming. It turns out that the flat-foldable internal vertices of each C2-symmetric unit fragment (UF) exist as C2-symmetric pairs about the centroid of the UF. Furthermore, numerical experiments are carried out to examine the feasibility and compare the accuracy, computational efficiency, and global convergence of the proposed methods. The results of numerical experiments demonstrated that, in comparison with the graphical method, the proposed PSO method has not only a higher accuracy but also a significantly lower computational cost, enabling us to develop an intelligent computational platform to efficiently design scalene-faceted flat-foldable origami tessellations.
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Macrophage Migration Inhibitory Factor (MIF) Interacts with Bim and Inhibits Bim-mediated Apoptosis
Lingfeng Liu,Jinzhong Chen,Chaoneng Ji,Jiayi Zhang,Junlei Sun,Yao Li,Yi Xie,Shaohua Gu,Yumin Mao 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.2
The pro-apoptotic Bcl-2 family member Bim acts as a sensor for apoptotic stimuli and initiates apoptosis through the mitochondrial pathway. To identify novel regulators of Bim, we employed the yeast two-hybrid system and isolated the human gene encoding macrophage migration inhibitory factor (MIF), a ubiquitously expressed proinflammatory mediator that has also been implicated in cell proliferation, the cell cycle and carcinogenesis. The interaction between MIF and Bim was confirmed by both in vitro and in vivo protein interaction assays. Intriguingly, protein complexes between MIF and the three major Bim isoforms (BimEL/BimL/BimS) could be detected in HEK293 and K562 cells, especially in cells undergoing apoptosis. Moreover, exogenous expression of MIF partially inhibited Bim-induced apoptosis in HEK293 cells. SiRNA-mediated knockdown of MIF increased apoptosis in K562 cells exposed to the chemical oxidant diamide. Endogenous MIF may regulate the pro-apoptotic activity of Bim and inhibit the release of cytochrome c from mitochondria.
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