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RISS 인기검색어
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- 저자 : Jianguang Wei (검색결과 4 건)
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Jianguang Wei,Xidong Ren,Hongyan Shao,Yuanyuan Ma,Xuemei Liu,Xuesong Lin 한국자원공학회 2016 Geosystem engineering Vol.19 No.5
The flow law near polymer flooding wellbores under the condition of perforation is very complex and there are many types of shaped charges. In this study, a non-Darcy flow model near polymer flooding wellbores was given, and a flow experiment was carried out to measure the resistance coefficient, residual resistance coefficient, and flow viscosity of the polymer solution in porous media under the conditions of different permeability and different polymer molecular weight. According to the results of numerical simulation, this paper calculated the flow efficiency of different types of shaped charges and evaluated the adaptability of different charges under polymer flooding condition. The results of this study have an important significance for guiding the optimization of shaped charges and the optimization design of perforating parameters.
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10-m long slim sandpack experiments to investigate gel system transport behavior in porous media
Jianguang Wei,Xin Zhang,Jiangtao Li,Runnan Zhou,Songze Liu 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.10
Understanding the transport behavior of a gel system in porous media is of great significance in enhancing oil recovery (EOR) for high water cut oil reservoirs. However, the length of the experiment models (sandpack or core sample) in current studies is usually in the range of centimeter scale, which is too short to track the full movement path of gel particles. In this work, 10-m long slim sandpacks were adopted to conduct gel flooding experiments. The pressure and polymer concentration distribution along the sandpack was tracked, and scanning electron microscope (SEM) technique was employed to observe the pore morphology after the gel flooding. The results show that the movement of polymer particles is usually within 7m away from the inlet due to the adsorption and retention in the porous medium. For 0.4 PV injection cases, SEM images show that the pore morphology at the inlet region exhibits a stable polymer network, while the network structure disappears at the outlet, along with the decrease of fluid viscosity from 620.1mPa·s to 1.2mPa·s. However, we can still find the stringy state polymer after 5m movement and the viscosity is 584.0mPa·s for 1 PV gel injection cases. Four characterization parameters, including equivalent viscosity, breakthrough pressure gradient, dimensionless gelation gradient, and plugging ratio, were proposed to quantitatively characterize the performance of gel flooding. In addition, empirical models were also obtained to predict the four parameters through multi-parameters fitting, and these models facilitate the characterization of the gel flooding performance. This is the first work, to the best of the authors’ knowledge, using long slim sandpack (10m) to experimentally study gel system transport in porous media, which provides theoretical implications in enhancing oil recovery.
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Effect of reservoir properties on the heat extraction performance in multi-well production EGS
Liu Songze,Wei Jianguang,Liu Hongliang,Liu Xuemei,Yan Bingxu 한국자원공학회 2021 Geosystem engineering Vol.24 No.4
A multi-well production enhanced geothermal system (EGS) with discrete fracture network is designed for heat extraction in this study. A thermal-hydraulic numerical simulation model is established, and the effect of reservoir properties on heat extraction is investigated. The results show that the growth rate of heat extraction efficiency will decrease as the mining time increases. The initial reservoir temperature has a positive correlation with average production temperature which provides a broad space for the use of extracted thermal energy. The variation of initial reservoir pressure has little effect on the heat extraction performance. A higher matrix permeability leads to a higher average production temperature and heat extraction ratio which prompts more working fluid flow into the matrix, the heat transfer process is enhanced. Under the conditions of this study, the preferred initial reservoir temperature is 493.15 K, the matrix permeability is 10−14m2.
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Exosomes derived from miR-214-3p overexpressing mesenchymal stem cells promote myocardial repair
Wenwu Zhu,Qingjie Wang,Jian Zhang,Ling Sun,Xiu Hong,Wei Du,Rui Duan,Jianguang Jiang,Yuan Ji,Haoran Wang,Bing Han 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Aims Exosomes are known as nanovesicles that are naturally secreted, playing an essential role in stem-mediated cardioprotection. This study mainly focused on investigating if exosomes derived from miR-214 overexpressing mesenchymal stem cells (MSCs) show more valid cardioprotective ability in a rat model of acute myocardial infarction (AMI) and its potential mechanisms. Methods Exosomes were isolated from control MSCs (Ctrl-Exo) and miR-214 overexpressing MSCs (miR-214OE-Exo) and then they were delivered to cardiomyocytes and endothelial cells in vitro under hypoxia and serum deprivation (H/SD) condition or in vivo in an acutely infarcted Sprague-Dawley rat heart. Regulated genes and signal pathways by miR-214OE-Exo treatment were explored using western blot analysis and luciferase assay. Results in vitro , miR-214OE-Exo enhanced migration, tube-like formation in endothelial cells. In addition, miR-214OE-Exo ameliorated the survival of cardiomyocytes under H/SD. In the rat AMI model, compared to Ctrl-Exo, miR-214OE-Exo reduced myocardial apoptosis, and therefore reduced infarct size and improved cardiac function. Besides, miR-214OE-Exo accelerated angiogenesis in peri-infarct region. Mechanistically, we identified that exosomal miR-214-3p promoted cardiac repair via targeting PTEN and activating p-AKT signal pathway. Conclusion Exosomes derived from miR-214 overexpressing MSCs have greatly strengthened the therapeutic efficacy for treatment of AMI by promoting cardiomyocyte survival and endothelial cell function.
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