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RISS 인기검색어
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- 저자 : Jiancheng Wu (검색결과 4 건)
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Jiancheng Tu,Shusheng Wang,Geping Wu,Yun Zuo,Lei Zhao 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
Alloferons are a group of naturally occurringpeptides primarily isolated from insects that are capable ofstimulating mouse and human NK cell cytotoxicity towardcancer cells. In this study, we found that a modified antibacterialpeptide had a broad range of action against bothgram-positive and gram-negative bacteria. A time-courseexperiment showed that CFU counts rapidly decreasedafter ZL-2 treatment, with the bacteria nearly eliminatedwithin 4 h. We also examined the synergy between thepeptide and antibiotics. The peptide ZL-2 resulted in asignificant synergistic improvement in the potencies ofampicillin, erythromycin and ceftazidime against methicillin-resistant bacteria. In addition, ZL-2 had no detectablecytotoxicity in mouse spleen cells or a mouse animalmodel. In the mouse model by i.p. inoculation with Escherichiacoli, timely treatment of i.p. injection with ZL-2resulted in 100-fold reduction in bacteria load in blood aswell as 80 % protection from death in the inoculated animals. In conclusion, we successfully identified a modifiedpeptide with maximal bactericidal activity. This study alsoprovides a potential therapeutic for the treatment of E. colisepticemia by increasing the activity of antimicrobials.
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Huiqun Wu,Chendong Wang,Cong Chen,Xiaotao Xu,Yi Zhu,Aimin Sang,Kui Jiang,Jiancheng Dong 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1
Background and Purpose Previous studies have explored the association between retinal vascular changes and cognitive impairment. The retinal vasculature shares some characteristics with the cerebral vasculature, and quantitative changes in it could indicate cognitive impairment. Hence, a comprehensive meta-analysis was performed to clarify the potential relationship between retinal vascular geometric changes and cognitive impairment. Methods Relevant databases were scrupulously and systematically searched for retinal vascular geometric changes including caliber, tortuosity, and fractal dimension (FD), and for cognitive impairment. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of included studies. RevMan was used to perform the meta-analysis and detect publication bias. Sensitivity analyses were also performed. Results Five studies that involved 2,343 subjects were finally included in the meta-analysis. The results showed that there was no significant association between central retinal artery equivalents (Z=1.17) or central retinal venular equivalents (Z=1.74) and cognitive impairment (both p>0.05). Similarly, no significant difference was detected in retinal arteriolar tortuosity (Z=0.91) and venular tortuosity (Z=1.31) (both p>0.05). However, the retinal arteriolar FD (mean difference: -0.03, 95% CI: -0.05, -0.01) and venular FD (mean difference: -0.03, 95% CI: -0.05, -0.02) were associated with cognitive impairment. Conclusions A smaller retinal microvascular FD might be associated with cognitive impairment. Further large-sample and well-controlled original studies are required to confirm the present findings.
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NOTE ON CONNECTED (g, f)-FACTORS OF GRAPHS
Sizhong Zhou,Jiancheng Wu,Quanru Pan 한국전산응용수학회 2010 Journal of applied mathematics & informatics Vol.28 No.3
In this note we present a short proof of the following result by Zhou, Liu and Xu. Let G be a graph of order n, and let a and b be two intergers with 1≤ a < b and b ≥ 3, and let g and f be two integer-valued functions defined on V (G) such that a ≤ g(x) < f(x) ≤ b for each x ∈ V(G)and f(V (G))−V (G) even. If [수식], then G has a connected (g,f)-factor.
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NOTE ON CONNECTED (g, f)-FACTORS OF GRAPHS
Zhou, Sizhong,Wu, Jiancheng,Pan, Quanru The Korean Society for Computational and Applied M 2010 Journal of applied mathematics & informatics Vol.28 No.3
In this note we present a short proof of the following result by Zhou, Liu and Xu. Let G be a graph of order n, and let a and b be two integers with 1 $\leq$ a < b and b $\geq$ 3, and let g and f be two integer-valued functions defined on V(G) such that a $\leq$ g(x) < f(x) $\leq$ b for each $x\;{\in}\;V(G)$ and f(V(G)) - V(G) even. If $n\;{\geq}\;\frac{(a+b-1)^2+1}{a}$ and $\delta(G)\;{\geq}\;\frac{(b-1)n}{a+b-1}$,then G has a connected (g, f)-factor.
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