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Jiali Cai,Guochuang Chen,Rongrong Jin,Changhui Deng,Shihui Huang,Xuexia Yuan,Gengjia Chen,Jing Zhao,Zhiyong Wang,Hua Ai 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-
Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies wereused to assist immunotherapy. Herein a visible polymer–inorganic hybrid gene vehicle had beenprepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus thesetransfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, thiscompound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitiveimaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system andthe gene product showed an outstanding immune effect. In conclusion, this nanocomposite showedsynergistic advantages in gene delivery and non-invasive MR imaging.
Huang Xin,Lv Danju,Chen Xu,Xi Rui,Zi Jiali,Gao Mingyuan,Zhang Yan 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.1
An orthogonal double-chain differential evolution (ODCDE) algorithm is proposed to optimize the problem’s parameters for workpiece processing. ODCDE improves the differential evolution structure by changing the parcels into the orthogonal chains in the adaptive search range of the solution, which can avoid falling into local optimum, improve the solution precision, and speed up the convergence speed. The superiority of the proposed algorithm was proved by the function performance test on three sets of bench functions, which reached the first place in the set of 23 functions with other 11 optimal algorithms, ranked the second in the CEC2017 functions with other more recent 5 algorithms, and ranked the seventh in the CEC2011 functions with other 11 algorithms including AMO, SFS, and GSK algorithms. Finally, two kinds of optimal workpiece processing, the tubular column design and the multipass milling, are studied, and the results show that our algorithm performs better than other methods.