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Zhang, Chunjuan,Grandner, Jessica,Liu, Ran,Lee, Sang Bok,Eichhorn, Bryan W. Royal Society of Chemistry 2010 Physical chemistry chemical physics Vol.12 No.17
<P>Heterogeneous films of ordered CeO<SUB>2</SUB>/Ni concentric nanostructures have been fabricated through template-assisted electrodeposition. The free-standing films of Ni metal (8 μm thickness) contain ordered arrays of ceria tubes (200 nm OD, 100 nm ID). Ni/CeO<SUB>2</SUB> coaxial nanotubes were also obtained by tuning experimental conditions. The interfacial contact area within the 3-dimensional oxide nanotube/nickel matrix is ∼100 times greater than 2-dimensional thin films of nickel and ceria of the same area. The use of the film as an anode electrocatalyst/current collector is demonstrated in a solid oxide fuel cell.</P> <P>Graphic Abstract</P><P>Heterogeneous films of ordered CeO<SUB>2</SUB>/Ni concentric nanostructures have been fabricated through template-assisted electrodeposition. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b918587a'> </P>
Elderly CADASIL patients with intact neurological status
Ruiting Zhang,Elisa Ouin,Lina Grosset,Karine Ighilkrim,Jessica Lebenberg,Stéphanie Guey,Véronique François,Elisabeth Tournier-Lasserve,Eric Jouvent,Hugues Chabriat 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.3
Background and Purpose Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most devastating cerebral small vessel diseases. However, despite its progression with aging, some patients remain neurologically intact (Nint) even when they get older. Their main characteristics are poorly known. We aimed to delineate their clinical, imaging, and molecular features. Methods Individuals aged over 65 years were selected from a cohort of 472 CADASIL patients. Subjects who had no focal deficit, cognitive impairment, or disability were considered Nint. Their demographic, genetic, clinical, and imaging features were compared to those with permanent neurological symptoms (Nps). Results Among 129 patients, 23 (17.8%) individuals were considered Nint. The frequency of vascular risk factors and NOTCH3 cysteine mutations in epidermal growth factor-like repeat (EGFr) domains 7-34 did not differ between Nint and Nps patients but Nint patients had less stroke events and were more likely to have migraine with aura. The number of lacunes and microbleeds and degree of brain atrophy were lower in the Nint group, but the volume of white matter hyperintensities did not differ between the two groups. Conclusions Nearly one in five CADASIL patients can remain Nint after the age of 65 years. Their clinical and imaging profile differed from that of other age-matched CADASIL patients. The location of NOTCH3 mutation inside or outside EGFr domains 1-6 cannot fully explain this discrepancy. The factors involved in their relative preservation of brain tissue from severe damage despite aging remain to be determined.
Yu, Liming,Tu, Qisheng,Han, Qianqian,Zhang, Lan,Sui, Lei,Zheng, Leilei,Meng, Shu,Tang, Yin,Xuan, Dongying,Zhang, Jin,Murray, Dana,Shen, Qingping,Cheng, Jessica,Kim, Sung-Hoon,Dong, Lily Q.,Valverde, P Wiley (John WileySons) 2015 Stem Cells Vol.33 No.1
<P>Adiponectin (APN) is an adipocyte-secreted adipokine that exerts well-characterized antidiabetic properties. Patients with type 2 diabetes (T2D) are characterized by reduced APN levels in circulation and impaired stem cell and progenitor cell mobilization from the bone marrow for tissue repair and remodeling. In this study, we found that APN regulates the mobilization and recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to participate in tissue repair and regeneration. APN facilitated BMSCs migrating from the bone marrow into the circulation to regenerate bone by regulating stromal cell-derived factor (SDF)-1 in a mouse bone defect model. More importantly, we found that systemic APN infusion ameliorated diabetic mobilopathy of BMSCs, lowered glucose concentration, and promoted bone regeneration in diet-induced obesity mice. In vitro studies allowed us to identify Smad1/5/8 as a novel signaling mediator of APN receptor (AdipoR)-1 in BMSCs and osteoblasts. APN stimulation of MC3T3-E1 osteoblastic cells led to Smad1/5/8 phosphorylation and nuclear localization and increased SDF1 mRNA expression. Although APN-mediated phosphorylation of Smad1/5/8 occurred independently from adaptor protein, phosphotyrosine interaction, pleckstrin homology domain, and leucine zipper containing 1, it correlated with the disassembly of protein kinase casein kinase 2 and AdipoR1 in immunoprecipitation experiments. Taken together, this study identified APN as a regulator of BMSCs migration in response to bone injury. Therefore, our findings suggest APN signaling could be a potential therapeutic target to improve bone regeneration and homeostasis, especially in obese and T2D patients.</P>
Brian Woodall,Mariel Borowitz,Kari Watkins,Maria Costa,Angela Howard,Perrine Kemerait,Michelle Lee,Gavin Rolls,Yuji Takubo,Rachel Titshaw,Maria Winstead,Jessica Zhang,Daisy Zhou 서울시립대학교 도시과학연구원 2024 도시과학국제저널 Vol.28 No.1
The megaregion is viewed as a platform from which to address a variety of issues. Despite agreement that a megaregion is a large, globally connected urban agglomeration, there is no consensus as to how to delineate its boundaries and how it differs from other urban forms. The scholarly literature is dominated by three distinct analytic approaches: interdependent systems, nodal linkages, and satellite data. We assess the utility of each approach in delineating the boundaries of four megaregions – BosWash, Greater Tokyo, the Amsterdam-Brussels-Antwerp region, and a Global South megaregion – and conclude by proposing a sequence of steps to guide future research.