Effects of Copper Reduction on Angiogenesis-Related Factors in Recurrent Glioblastoma Cases

Jazayeri, Shima,Feli, Alireza,Bitaraf, Mohammad Ali,Dodaran, Masoud Solaymani,Alikhani, Mazdak,Hosseinzadeh-Attar, Mohammad Javad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10

Purpose: To evaluate the therapeutic effects of copper reduction on angiogenesis-related factors in patients with glioblastoma multiforme treated by gamma knife radiosurgery. Materials and Methods: In the present block randomized, placebo-controlled trial, fifty eligible patients with a diagnosis of glioblastoma multiforme who were candidates for gamma knife radiosurgery were randomly assigned into two groups to receive daily either 1gr penicillamine and a low copper diet or placebo for three months. The intervention started on the same day as gamma knife radiosurgery. Serum interleukin-6 (IL-6), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), vascular endothelial growth factor (VEGF) and copper levels were measured at baseline and after the intervention. The serum copper level was used as the final index of compliance with the diet. In order to control probable side effects of intervention, laboratory tests were conducted at the beginning, middle and end of the study. Results: The patients had a mean age and Karnofsky Performance Scale of 43.7 years and 75 respectively. Mean serum copper levels were significantly reduced in intervention group. Mean survival time was 18.5 months in intervention group vs. 14.9 in placebo group. VEGF and IL-6 levels in the intervention group were also significantly reduced compared to the placebo group and $TNF-{\alpha}$ increased less. Conclusions: It seems that reducing the level of copper in the diet and dosing with penicillamine leads to decline of angiogenesis-related factors such as VEGF, IL-6 and $TNF-{\alpha}$. Approaches targeting angiogenesis may improve survival and can be used as a future therapeutic strategy.

Advancements in craniofacial prosthesis fabrication: A narrative review of holistic treatment

Jazayeri, Hossein E.,Kang, Steve,Masri, Radi M.,Kuhn, Lauren,Fahimipour, Farahnaz,Vanevenhoven, Rabecca,Thompson, Geoffrey,Gheisarifar, Maryam,Tahriri, Mohammadreza,Tayebi, Lobat The Korean Academy of Prosthodonitics 2018 The Journal of Advanced Prosthodontics Vol.10 No.6

The treatment of craniofacial anomalies has been challenging as a result of technological shortcomings that could not provide a consistent protocol to perfectly restore patient-specific anatomy. In the past, wax-up and impression-based maneuvers were implemented to achieve this clinical end. However, with the advent of computer-aided design and computer-aided manufacturing (CAD/CAM) technology, a rapid and cost-effective workflow in prosthetic rehabilitation has taken the place of the outdated procedures. Because the use of implants is so profound in different facets of restorative dentistry, their placement for craniofacial prosthesis retention has also been widely popular and advantageous in a variety of clinical settings. This review aims to effectively describe the well-rounded and interdisciplinary practice of craniofacial prosthesis fabrication and retention by outlining fabrication, osseointegrated implant placement for prosthesis retention, a myriad of clinical examples in the craniofacial complex, and a glimpse of the future of bioengineering principles to restore bioactivity and physiology to the previously defected tissue.

Epidemiology of Primary CNS Tumors in Iran: A Systematic Review

Jazayeri, Seyed Behzad,Rahimi-Movaghar, Vafa,Shokraneh, Farhad,Saadat, Soheil,Ramezani, Rashid Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: Although primary malignant CNS tumors are registered in the national cancer registry (NCR) of Iran, there are no available data on the incidence of the primary malignant or benign CNS tumors and their common histopathologies in the country. This study analyzed the 10-year data of the Iranian NCR from March 21, 2000 to March 20, 2010, including a systematic review. Materials and Methods: The international and national scientific databases were searched using the search keywords CNS, tumor, malignancy, brain, spine, neoplasm and Iran. Results: Of the 1,086 primary results, 9 papers were selected and reviewed, along with analysis of 10-year NCR data. The results showed that primary malignant brain tumors have an overall incidence of 2.74 per 100,000 person-years. The analysis of the papers revealed a benign to malignant ratio of 1.07. The most common histopathologies are meningioma, astrocytoma, glioblastoma and ependymoma. These tumors are more common in men (M/F=1.48). Primary malignant spinal cord tumors constitute 7.1% of the primary malignant CNS tumors with incidence of 0.21/100,000. Conclusions: This study shows that CNS tumors in Iran are in compliance with the pattern of CNS tumors in developing countries. The NCR must include benign lesions to understand the definitive epidemiology of primary CNS tumors in Iran.

Sympathetic Skin Response in Patients with Vascular Erectile Dysfunction

Mostafa Jazayeri,Behrooz Kazemi,Alireza Aminsharifi,Alireza Ashraf,Mahshid Naseri,Ali Nasseri,Amirhooshang Vahedi 대한남성과학회 2014 The World Journal of Men's Health Vol.32 No.1

Purpose: We aimed to investigate the utility of sympathetic skin response (SSR) test for evaluating vasculogenic erectile dysfunction (ED) which is the most common type of impotence. Materials and Methods: Men in the age group of 28 to 60 years and suffering from vasculogenic ED, as confirmed by a papaverin test and color Doppler sonography, at least for 6 months referred from our university urology department were included. We used the International Index of Erectile Function (IIEF-5) for grading severity of dysfunction and recorded the SSR of every patient from the median, tibial, and dorsal nerves of the penis. One-way analysis of variance (ANOVA), independent t-test and Pearson’s correlation coefficient were used for comparing quantitative variables, and Fisher's Exact test was used for comparing qualitative variables. The Mann-Whitney U Test and the Kruskal-Wallis test were performed for analysis of data that were not normally distributed. A p value of less than 0.05 was considered significant. Results: Forty-two patients were recruited for the study. We found a strong statistical relationship between the IIEF score and the pathologic SSR registered from every mentioned nerve. Patients with abnormal SSR had more severe ED according to IIEF score (p<0.001). In addition, the IIEF score had a significantcorrelation with diabetes mellitus and cardiovascular disease (t-test; p<0.05). Conclusions: Our results confirmed the presence of autonomic dysfunction in patients with vasculogenic impotence via an SSR test. We suggest evaluating the efficacy of the SSR test in patients with vascular impotence for treatment response monitoring in future studies.

Transient Protection Optimization of Pipelines Using Air-chamber and Air-inlet Valves

S. Mahmood Jazayeri Moghaddas,Hossein M. V. Samani,Ali Haghighi 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.5

Air-chambers are mechanical devices capable of decreasing positive and increasing negative water-hammer pressures in pumping pipelines; however, large size air-chambers might increase the costs substantially. Also, air-inlet valves are powerful devices which can efficiently control negative pressures. Obtaining the best protection scheme where transient pressures are maintained in a safe bound while minimizing the protection cost is an optimization problem. In this research, a single objective optimization model is introduced in which the types and locations of air-inlet valves and the size of air-chamber are determined such that the total cost is minimized while all pressures along the pipeline are in the allowable range. Maximum and minimum transient pressures are considered as constraints in the optimization analysis using penalty functions. A self-adaptive real genetic algorithm is used to solve the problem. The model is applied to a real transmission pipeline with 4 m3/s flow capacity. The results indicate that the proposed model is capable to determine proper number of air-inlet valves, their locations and types so that the air-chamber size and the total cost are substantially reduced.

Histological study on the skin structure in two mudskippers, Periophthalmus waltoni and Boleophthalmus dussumieri in relation to their terrestrial life

Dorostghoal Mehran,Jazayeri Ashraf,Ashiri Sara 한국현미경학회 2022 Applied microscopy Vol.52 No.1

Microscopic structure of skin in two amphibious mudskipper fish; Boleophthalmus dussumieri Valenciennes, 1837 ( B. dussumeri ) and Periophthalmus waltoni Koumans, 1941 (P. waltoni) were investigated in relation to their lifestyle. The general structure of skin is the same among the two species. Epidermis in B. dussumeri was thicker significantly than P. waltoni . The dermal bulges were only well developed in the skin of B. dussumeri . Mucous cells were absent in the epidermis of P. waltoni but present in B. dussumeri . Both B. dussumeri and P. waltoni have well-developed swollen middle cells as a shared epidermal feature. The thickness of the middle cell layer of the epidermis in B. dussumeri was significantly greater than in P. waltoni . Capillaries in the dorsal and ventral parts of the body are more closely distributed to the epidermal surface in P. waltoni than in B. dussumeri . The diffusion distance in the dorsal epidermis of P. waltoni was less than that in the ventral epidermis of B. dussumeri . A comparative examination of the skin of mudskipper species suggests that, due to the more terrestrial lifestyle adopted by P. waltoni , the skin contributes more to respiration.

Integrated nozzle - flapper valve with piezoelectric actuator and isothermal chamber: a feedback linearization multi control device

Mohammadreza Kamali,Seyed Ali Jazayeri,Farid Najafi,Kenji Kawashima,Toshiharu Kagawa 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.5

This paper introduces a new nozzle-flapper valve with isothermal chamber using piezoelectric actuator. It controls the pressure and flow rate simply, effectively and separately. The proposed valve uses isothermal chamber presenting practical isothermal condition due to its large heat transfer interfaces filled by metal wool. The valve uses stacked type piezoelectric actuator with unique advantages. By using this valve, a simple method has been fulfilled to control flow rate or pressure of ideal gases in a pneumatic actuators. Experimental results demonstrated applications of the proposed valve to control either pressure or flow rate in pneumatic circuits. This valve can be also used in the pilot stage valve to actuate the main stage of a much bigger pneumatic valve. Designated structure contains only one pressure sensor installed on the isothermal control chamber, capable of controlling both pressure and flow rate. The desired output mass flow rate of the valve is controlled by the pressure changes during positioning of piezoelectric actuator at proper position. The proposed valve can control steady and unsteady oscillatory flow rate and pressure effectively, using nonlinear control method such as feedback linearization approach. Its effectiveness is demonstrated and validated through simulation and experiments.

Iatrogenic False Aneurysm of the Internal Thoracic Artery after Sternotomy: The Role of Doppler Ultrasound

Rémy Hamdan,Saed Jazayeri,Beatrice Terriat,Iman Melin-Boucetta 대한혈관외과학회 2022 Vascular Specialist International Vol.38 No.3

Diet-Related Stomach Cancer Behavior Among Iranian College Students: A Text Messaging Intervention

Dehdari, Tahereh,Dehdari, Laleh,Jazayeri, Shima Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12

Background: Stomach cancer is one of the five most common cancers in Iran. This study examined the effectiveness of a mobile telephone short-message service (SMS) based-education intervention using Health Belief Model (HBM) variables in improving dietary behavior in terms of stomach cancer prevention among a sample of Iranian female college students. Materials and Methods: In this quasi-experimental study, 124 female college students in the dormitories of Yazd University, Yazd, Iran were randomly selected and assigned to either the intervention (n=62) or the control group (n=62). Information (data) regarding HBM variables and dietary behavior related to stomach cancer prevention was collected by a self-administrated questionnaire. Forty eight messages were designed and sent to the participants' phones in the intervention group during the 48-day intervention period. Two groups were followed-up one month after the intervention delivered via SMS. Results: There were significant differences in HBM variables (except for the perceived severity) and the preventive dietary behaviors for stomach cancer in the intervention group compared to the comparison group following the education intervention delivered via SMS. Conclusions: SMS-delivered nutrition education intervention can be a practical strategy to improve dietary behavior related to stomach cancer prevention.

Effect of nepheline syenite on the colorant behavior of porcelain stoneware body

A. Salem,S.H. Jazayeri,E. Rastelli,G. Timellini 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.5

The effects of nepheline syenite on the colorant behavior of porcelain stoneware tiles were assessed with special reference to the body composition. Potassium feldspar was replaced by nepheline syenite in a typical porcelain stoneware body by up to 15.6 wt.%. Technological parameters such as shrinkage, water absorption and porosity were measured. Phase composition and microstructural characteristics were determined to understand the role of nepheline syenite in the whiteness of a ceramic body. The results show that nepheline syenite had a significant effect on the sintering rate and influences remarkably the sintering behavior, increasing the shrinkage and decreasing total porosity. On the other hand there is a decrease in the amounts of mullite and quartz with addition of nepheline syenite. The bodies richer in nepheline syenite show larger amounts of albite and glassy phase. These bodies also present a higher whiteness with the same sintering conditions. The colorant characteristics appear to be directly related to the free albite crystals content. In conclusion nepheline syenite can be used in small amounts, 5 wt.%, to obtain an effective color development. The effects of nepheline syenite on the colorant behavior of porcelain stoneware tiles were assessed with special reference to the body composition. Potassium feldspar was replaced by nepheline syenite in a typical porcelain stoneware body by up to 15.6 wt.%. Technological parameters such as shrinkage, water absorption and porosity were measured. Phase composition and microstructural characteristics were determined to understand the role of nepheline syenite in the whiteness of a ceramic body. The results show that nepheline syenite had a significant effect on the sintering rate and influences remarkably the sintering behavior, increasing the shrinkage and decreasing total porosity. On the other hand there is a decrease in the amounts of mullite and quartz with addition of nepheline syenite. The bodies richer in nepheline syenite show larger amounts of albite and glassy phase. These bodies also present a higher whiteness with the same sintering conditions. The colorant characteristics appear to be directly related to the free albite crystals content. In conclusion nepheline syenite can be used in small amounts, 5 wt.%, to obtain an effective color development.