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RISS 인기검색어
- 검색키워드
- 저자 : J. Govindarajan (검색결과 3 건)
- 무료
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- 유료
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Effects of Obesity on Cervical Disc Arthroplasty Complications
Katherine M. Berry,Vaidya Govindarajan,Connor Berger,Krisna Maddy,Roberto J. Perez Roman,Evan M. Luther,Allan D. Levi 대한척추신경외과학회 2023 Neurospine Vol.20 No.4
Objective: High body mass index is a well-established modifiable comorbidity that is known to increase postoperative complications in all types of surgery, including spine surgery. Obesity is increasing in prevalence amongst the general population. As this growing population of obese patients ages, understanding how they faire undergoing cervical disc arthroplasty (CDA) is important for providing safe and effective evidence-based care for cervical degenerative pathology. Methods: Our study used the Healthcare Cost and Utilization Project’s National Inpatient Sample to assess patients undergoing CDA comparing patient characteristics and outcomes in nonobese patients to obese patients from 2004 to 2014. Results: Our study found a significant increase in the overall utilization of CDA as a treatment modality (p = 0.012) and a statistically significant increase in obese patients undergoing CDA (p < 0.0001) from 2004 to 2014. Obesity was identified as an independent risk factor associated with increased rates of inpatient neurologic complications (odds ratio [OR], 6.99; p = 0.03), pulmonary embolus (OR, 5.41; p = 0.05), and wound infection (OR, 6.97; p < 0.001) in patients undergoing CDA from 2004 to 2014. Conclusion: In patients undergoing CDA, from 2004 to 2014, obesity was identified as an independent risk factor with significantly increased rates of inpatient neurologic complications, pulmonary embolus and wound infection. Large prospective trials are needed to validate these findings.
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Enhancement of Learning and Memory by Elevating Brain Magnesium
Slutsky, I.,Abumaria, N.,Wu, L.J.,Huang, C.,Zhang, L.,Li, B.,Zhao, X.,Govindarajan, A.,Zhao, M.G.,Zhuo, M.,Tonegawa, S.,Liu, G. Cell Press 2010 Neuron Vol.65 No.2
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.
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Measurement of emission current and temperature profile of emissive probe materials using CO_2 LASER
Payal Mehta,Arun Sarma,Joydeep Ghosh,Shwetang Pandya,Santosh Pandya,Paritosh Choudhuri,J. Govindarajan,C. Ionita Schrittwieser,Roman Schrittwieser 한국물리학회 2011 Current Applied Physics Vol.11 No.5
Emissive probes have been used for the direct measurement of plasma potential in many plasma devices. Different approaches have been introduced to measure the plasma potential using emissive probes. But the biggest disadvantage of the emissive probe is short life span due to its self-arrangement and different plasma environment. Few initiations have been made to measure plasma potential by using LASER heated emissive probe. In case of LASER heated emissive probe, mostly graphite and LaB_6 are being used as probe tip to emit electrons by heating with LASER light. However, very little studies have been done to understand the mechanism of heating process of the LaB_6 and graphite materials. The complete heating dynamics of these materials, heated by a CW CO_2 LASER with a maximum 55Wpower have been studied in this work. In-situ temperature of the probe tip has been measured by using an IR camera. Complete theoretical and simulated model have been developed to understand the experimentally measured data. Further, the experimental results are compared with ANSYS simulations. The emission current from the probe with respect to the bias voltage applied to the probe has also been measured.
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