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RISS 인기검색어
- 검색키워드
- 저자 : Imre Nagy (검색결과 2 건)
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Experimental simulation of activity release from leaking fuel rods
Barbara Somfai,Zoltan Hozer,Imre Nagy 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.7
The Leaking Fuel Experiment test facility was designed to simulate the activity release from spent leakingfuel rods under steady state and transient conditions in the spent fuel pool. The experimental rigincluded an electrically heated fuel rod with different defects and a cooling system. The fission producttransport was simulated by potassium-chloride. The conductivity changes of the water in the coolingsystem were measured to provide information about the amount of released solution. Defects of differentsizes and positions were applied, together with a wide range of rod powers to simulate decay heat. Theproduced data can be used for predicting the activity release from leaking fuel under storage conditionsand for the interpretation of fuel examination procedures
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Gene network and canonical pathway analysis in prostatecancer: a microarray study
Hakan Savli,Attila Szendrӧi,Imre Romics,Balint Nagy 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.2
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets. The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets.
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