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RISS 인기검색어
- 검색키워드
- 저자 : Ikizler, Sabriye Banu (검색결과 3 건)
- 무료
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Assessment of swelling pressure of stabilized Bentonite
Angin, Zekai,Ikizler, Sabriye Banu Techno-Press 2018 Geomechanics & engineering Vol.15 No.6
In this study, a comprehensive laboratory experimental programme was conducted on expansive soil with a high swelling potential to study the influence of different additive materials on swelling pressure and index properties. Lime, sand, multifilament fiber and fibrillated fiber were used for stabilization of expansive soil. Lime, sand and fibers were respectively added to the expansive soil at 0-7%, 0-80%, 0-0.5%. On each mixture that was prepared by the proportions mentioned above, Atterberg limits, compaction, and swelling pressure tests were conducted. From the result of these experiments, the swelling pressure-time relation could be replaced by a rectangular hyperbola established to facilitate the prediction of ultimate percent swelling with a few initial data points. The best type of additive and its optimum ratio for engineering purposes could be estimated rapidly by this approach.
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Assessment of liquefaction potential of the Erzincan, Eastern Turkey
Duman, Esra Subasi,Ikizler, Sabriye Banu,Angin, Zekai,Demir, Gokhan Techno-Press 2014 Geomechanics & engineering Vol.7 No.6
This study includes determination of liquefaction potential in Erzincan city center. Erzincan Province is situated within first-degree earthquake zone on earthquake map of Turkey. In this context, the earthquake scenarios were produced using the empirical expressions. Liquefaction potential for different earthquake magnitudes (6.0, 6.5, 7.0) were determined. Liquefaction potential was investigated using Standard Penetration Test (SPT). Liquefaction potential analyses are determined in two steps: geotechnical investigations and calculations. In the first steps, boreholes were drilled to obtain disturbed and undisturbed soil samples and SPT values were obtained. Laboratory tests were made to identify geotechnical properties of soil samples. In the second step, liquefaction potential analyses were examined using two methods, namely Seed and Idriss (1971), Iwasaki et al. (1981). The liquefaction potential broadly classified into three categories, namely non-liquefiable, marginally liquefiable and liquefiable regions. Additionally, the liquefaction potential index classified into four categories, namely non-liquefiable, low, high and very high liquefiable regions. In order to liquefaction analysis complete within a short time, MATLAB program were prepared. Following the analyses, liquefaction potential index is investigated by Iwasaki et al. (1982) methods. At the final stage of this study, liquefaction potential maps and liquefaction potential index maps of the all study area by using IDW (inverse distance weighted) interpolation method in Geostatistical Analyst Module of ArcGIS 10.0 Software were prepared for different earthquake magnitudes and different depths. The results of soil liquefaction potential were evaluated in ArcGIS to map the distributions of drillings with liquefaction potential. The maps showed that there is a spatial variability in the results obtained which made it difficult to clearly separate between regional areas of high or low potential to liquefy. However, this study indicates that the presence of ground water and sandy-silty soils increases the liquefaction potential with the seismic features of the region.
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Skeletal muscle energetics in patients with moderate to advanced kidney disease
Ertuglu Lale,Yildiz Abdulmecit,Gamboa Jorge,Ikizler T. Alp 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.1
Sarcopenia, defined as decrease in muscle function and mass, is common in patients with moderate to advanced chronic kidney disease (CKD) and is associated with poor clinical outcomes. Muscle mitochondrial dysfunction is proposed as one of the mechanisms underlying sarcopenia. Patients with moderate to advanced CKD have decreased muscle mitochondrial content and oxidative capacity along with suppressed activity of various mitochondrial enzymes such as mitochondrial electron transport chain complexes and pyruvate dehydrogenase, leading to impaired energy production. Other mitochondrial abnormalities found in this population include defective beta-oxidation of fatty acids and mitochondrial DNA mutations. These changes are noticeable from the early stages of CKD and correlate with severity of the disease. Damage induced by uremic toxins, oxidative stress, and systemic inflammation has been implicated in the development of mitochondrial dysfunction in CKD patients. Given that mitochondrial function is an important determinant of physical activity and performance, its modulation is a potential therapeutic target for sarcopenia in patients with kidney disease. Coenzyme Q, nicotinamide, and cardiolipin-targeted peptides have been tested as therapeutic interventions in early studies. Aerobic exercise, a well-established strategy to improve muscle function and mass in healthy adults, is not as effective in patients with advanced kidney disease. This might be due to reduced expression or impaired activation of PGC1-α, the master regulator of mitochondrial biogenesis. Further studies are needed to broaden our understanding of the pathogenesis of mitochondrial dysfunction and to develop mitochondrial-targeted therapies for prevention and treatment of sarcopenia in patients with CKD.
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